426 Results for "

triterpene skeleton

" in MedChemExpress (MCE) Product Catalog:
Products (426)

426 Results for "triterpene skeleton" in MCE Product Catalog:

20
Asiaticoside
Asiaticoside
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20 Publications Verification
Cat. No.: HY-N0439
CAS No.: 16830-15-2
Category:  

Cardiovascular Disease Triterpenes Neurological Disease Endogenous metabolite Umbelliferae/Apiaceae Extract Plant Centella asiatica (L.) Urb. Extract Terpenoids Disease Research Fields Cancer

Target:  

p38 MAPK TGF-beta/Smad Reactive Oxygen Species (ROS) Apoptosis Endogenous Metabolite

Asiaticoside, a trisaccaride triterpene from Centella asiatica, suppresses TGF-β/Smad signaling through inducing Smad7 and inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts; Asiaticoside shows antioxidant, anti-inflammatory, and anti-ulcer properties.
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13
Saikosaponin D
Saikosaponin D
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13 Cited Publications
Cat. No.: HY-N0250
CAS No.: 20874-52-6
Category:  

Umbelliferae/Apiaceae Extract Infection Triterpenes Plant Terpenoids Bupleurum chinensis DC. Extract Disease Research Fields Inflammation/Immunology

Target:  

STAT NF-κB Estrogen Receptor/ERR Bacterial

Saikosaponin D is a triterpene saponin isolated from Bupleurum, with anti-inflammatory, anti-bacterial, anti-tumor, and anti-allergic activities; Saikosaponin D inhibits selectin, STAT3 and NF-kB and activates estrogen receptor-β.
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7
2-Ketoglutaric acid
2-Ketoglutaric acid
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7 Cited Publications
Cat. No.: HY-W013636
CAS No.: 328-50-7
Synonyms: Alpha-Ketoglutaric acid; 2-Oxoglutaric acid
Category:  

Anti-aging Endocrine diseases Endogenous metabolite Immune System Disorder Ketones, Aldehydes, Acids Other Diseases Disease markers Nervous System Disorder Microorganism Disease Research Fields

Target:  

Tyrosinase Endogenous Metabolite

2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM) .
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7
2-Ketoglutaric acid Sodium
2-Ketoglutaric acid Sodium
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7 Cited Publications
Cat. No.: HY-W013636A
CAS No.: 22202-68-2
Synonyms: Alpha-Ketoglutaric acid Sodium
Category:  

Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Tyrosinase Endogenous Metabolite

2-Ketoglutaric acid Sodium (Alpha-Ketoglutaric acid Sodium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid Sodium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid Sodium is a reversible inhibitor of tyrosinase (IC50=15 mM) .
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7
Calcium 2-oxoglutarate
Calcium 2-oxoglutarate
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7 Cited Publications
Cat. No.: HY-W013636B
CAS No.: 71686-01-6
Category:  

Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Tyrosinase Endogenous Metabolite

Calcium 2-oxoglutarate is an intermediate in the production of ATP or GTP in the Krebs cycle. Calcium 2-oxoglutarate also acts as the major carbon skeleton for nitrogen-assimilatory reactions. Calcium 2-oxoglutarate is a reversible inhibitor of tyrosinase (IC50=15 mM) .
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7
2-Ketoglutaric acid potassium
2-Ketoglutaric acid potassium
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7 Cited Publications
Cat. No.: HY-W013636C
CAS No.: 997-43-3
Synonyms: Alpha-Ketoglutaric acid potassium
2-Ketoglutaric acid (Alpha-Ketoglutaric acid) (potassium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid potassium is a reversible and orally active inhibitor of tyrosinase with an IC50 value of 15 mM. 2-Ketoglutaric acid potassium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid potassium significantly suppresses abnormal intestinal permeability, delocalization of tight junction proteins from the intestinal cells, expression of TNFα in vitro and in vivo. 2-Ketoglutaric acid potassium directly binds to TAK1, and inhibits the TRAF6-TAK1 interaction. 2-Ketoglutaric acid potassium also alleviates inflammatory bowel disease (IBD) symptoms and gut microbiota dysbiosis, evident by the improvements in the intestine length .
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6
Asiatic acid
Asiatic acid
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6 Cited Publications
Cat. No.: HY-N0194
CAS No.: 464-92-6
Category:  

Umbelliferae/Apiaceae Extract Triterpenes Plant Centella asiatica (L.) Urb. Extract Terpenoids Disease Research Fields Inflammation/Immunology

Target:  

Apoptosis Parasite

Asiatic acid, a pentacyclic triterpene found in Centella asiatica (Centella asiatica), has anticancer activity. Asiatic acid induces apoptosis in melanoma cells and has barrier protective effects on human aortic endothelial cells (HAEC). Asiatic acid also has anti-inflammatory activity and inhibits tumor necrosis factor (TNF)-α-induced endothelial barrier dysfunction. Asiatic acid also inhibits NLRP3 inflammasome activation and NF-κB pathway, effectively inhibits inflammation in rats, and has neuroprotective effects in rat spinal cord injury (SCI) model .
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5
Betulonic acid
Betulonic acid
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5 Cited Publications
Cat. No.: HY-N1451
CAS No.: 4481-62-3
Synonyms: Betunolic acid; Liquidambaric acid; (+)-Betulonic acid
Category:  

Infection Triterpenes Plant Terpenoids Other Families Extract Disease Research Fields Inflammation/Immunology

Target:  

Parasite HSV

Betulonic acid (Betunolic acid), a naturally occurring triterpene, is found in many plants. Betulonic acid has anti-tumor, anti-inflammatory, antiparasitic and anti-viral (HSV-1) activities .
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3
Echinocystic acid
Echinocystic acid
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3 Cited Publications
Cat. No.: HY-N0271
CAS No.: 510-30-5
Category:  

Leguminosae/Fabaceae Extract Triterpenes Plant Gleditsia sinensis Lam. Extract Terpenoids Disease Research Fields Cancer

Target:  

Reactive Oxygen Species (ROS) Apoptosis

Echinocystic acid is a natural pentacyclic triterpene with potent antioxidant, anti-inflammatory and analgesic activities .
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3
Madecassoside
Madecassoside
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3 Cited Publications
Cat. No.: HY-N0568
CAS No.: 34540-22-2
Synonyms: Asiaticoside A
Category:  

Umbelliferae/Apiaceae Extract Triterpenes Plant Centella asiatica (L.) Urb. Extract Terpenoids Other Diseases Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite Apoptosis Autophagy Keap1-Nrf2 p38 MAPK Caspase

Madecassoside is a pentacyclic triterpene isolated from Centella asiatica and has anti-inflammatory properties. Antioxidant and anti-aging effects. Madecassoside is a pentacyclic triterpene isolated from Centella asiatica. Madecassoside is orally active and has inhibitory properties against inflammation, oxidation, apoptosis and autophagy. Madecassosid inhibits activities of p38 MAPK and NF-kB , exhibits an anti-apopototic property, activates Nrf2 expression to reduce the neurotoxicity . Madecassoside can be used in endocrine diseases, cardiovascular diseases, skin diseases and other diseases.
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3
Sodium aescinate
Sodium aescinate
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3 Cited Publications
Cat. No.: HY-N1404
CAS No.: 20977-05-3
Category:  

Aesculus hippocastanum Extract Triterpenes Plant Hippocastanaceae Extract Terpenoids Disease Research Fields Inflammation/Immunology

Target:  

NF-κB

Sodium aescinate is a triterpene saponin derived from Aesculus hippocastanum seeds, with anti-inflammatory and antioxidant activities . Sodium aescinate inhibits hepatocellular carcinoma growth by targeting CARMA3/NF-κB pathway .
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3
Panaxatriol
Panaxatriol
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3 Cited Publications
Cat. No.: HY-N0597
CAS No.: 32791-84-7
Category:  

Triterpenes Plant Terpenoids Panax ginseng C. A. Meyer Extract Other Diseases Disease Research Fields Araliaceae Extract

Target:  

Akt Insulin Receptor Apoptosis Reactive Oxygen Species (ROS)

Panaxatriol is an orally active dammarane-type tetracyclic triterpene sapogenin. Panaxatriol enhances the phosphorylation levels of Akt, insulin receptor and p70S6K in skeletal muscle. Panaxatriol reduces the mRNA expression level of Atrogin1 in skeletal muscle. Panaxatriol induces apoptosis, pre-G1 cell cycle arrest and increased intracellular ROS levels in prostate cancer cells, decreases mitochondrial membrane potential, inhibits cell migration and reduces colony formation. Panaxatriol can be used in research related to insulin resistance, myocardial ischemia/reperfusion injury and prostate cancer [1][2][3].
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2
Tormentic acid
Tormentic acid
0 Images
2 Cited Publications
Cat. No.: HY-N4137
CAS No.: 13850-16-3
Category:  

Cardiovascular Disease Triterpenes Plant Terpenoids Rosaceae Extract Rosa rugosa Thunb. Extract Disease Research Fields

Target:  

Others

Tormentic acid, a triterpene isolated from Rosa rugosa, exerts anti-inflammatory, antihyperlipidemic, and anti-atherogenic properties .
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2
Glycerol 3-phosphate Oxidase, Aerococcus viridans
Glycerol 3-phosphate Oxidase, Aerococcus viridans
0 Images
2 Cited Publications
Cat. No.: HY-P2733B
CAS No.: 9046-28-0
Synonyms: GPO, Aerococcus viridans
Target:  

Endogenous Metabolite

Research Areas:  

Metabolic Disease

Glycerol-3-phosphate oxidase, Aerococcus viridans (GPO, Aerococcus viridans) is a key intermediate in glycerol metabolism. Glycerol-3-phosphate oxidase is the skeleton of phospholipids in membrane lipids, and also a substrate of respiratory chain. Glycerol-3-phosphate oxidase produces electrons through oxidation .
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2
Usnic acid
Usnic acid
0 Images
2 Cited Publications
Cat. No.: HY-N0656
CAS No.: 125-46-2
Category:  

Natural Products Usnea diffracta Vain. Extract Infection Plant Sunscreen Phenols Polyphenols Cosmetic Research Disease Research Fields Usneaceae Extract

Target:  

Bacterial DNA/RNA Synthesis Nuclear Factor of activated T Cells (NFAT) Apoptosis

Usnic acid is a secondary metabolite of lichens with a unique dibenzofuran skeleton. Usnic acid inhibits DNA/RNA synthesis and has antibacterial activity. Usnic acid induces cell cycle arrest and apoptosis and has anticancer activity. Usnic acid inhibits RANKL-mediated osteoclast formation and function by reducing the transcriptional and translational expression of NFATc1. Usnic acid has antioxidant and anti-inflammatory activities by inhibiting lipid peroxidation and myeloperoxidase .
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2
Glycerol-3-phosphate oxidase, E. coli
Glycerol-3-phosphate oxidase, E. coli
0 Images
2 Cited Publications
Cat. No.: HY-P2733
CAS No.: 9046-28-0
Synonyms: GPO
Target:  

Endogenous Metabolite Bacterial

Research Areas:  

Infection Metabolic Disease

Glycerol-3-phosphate oxidase, E. coli (GPO) is a key intermediate in glycerol metabolism. Glycerol-3-phosphate oxidase, E. coli is the skeleton of phospholipids in membrane lipids, and also a substrate in the respiratory chain. Glycerol-3-phosphate oxidase, E. coli produces electrons through oxidation. Glycerol-3-phosphate oxidase, E. coli is an enzyme with important functions in the field of biochemistry, and is widely used in medical testing and scientific research .
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2
Oleanonic acid
Oleanonic acid
0 Images
2 Cited Publications
Cat. No.: HY-N1487
CAS No.: 17990-42-0
Synonyms: 3-Oxooleanolic acid
Category:  

Triterpenes Plant Terpenoids Other Families Extract Disease Research Fields Cancer

Target:  

HIV Autophagy Ferroptosis Amyloid-β

Oleanonic acid (3-Oxooleanolic acid) is an orally available triterpene that has anti-inflammatory and insecticidal properties. In vitro, oleanonic acid can improve oxidative stress, autophagy defects, ferroptosis, mitochondrial damage, and endoplasmic reticulum stress induced by Amyloid-β, and in vivo, it can alleviate myocardial hypertrophy in rats .
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2
Nimbolide
Nimbolide
0 Images
2 Cited Publications
Cat. No.: HY-116035
CAS No.: 25990-37-8
Purity:  99.79%
Category:  

Triterpenes Plant Terpenoids Meliaceae Extract Disease Research Fields Azadirachta indica A. Juss. Extract Cancer

Target:  

Wnt NF-κB CDK Apoptosis

Nimbolide is a triterpene compound that can be isolated from neem (Azadirachta indica), possesses anticancer and antiproliferative activity. Nimbolide induces tumor cell apoptosis by inhibiting NF-κB and CDK4/CDK6 kinase. Nimbolide suppresses the Wnt, PI3K-Akt, MAPK and JAK-STAT signaling pathways .
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2
Esculentoside A
Esculentoside A
0 Images
2 Cited Publications
Cat. No.: HY-N0632
CAS No.: 65497-07-6
Category:  

Phytolaccaceae Extract Triterpenes Plant Terpenoids Disease Research Fields Inflammation/Immunology Phytolacca acinosa Roxb. Extract

Target:  

COX NF-κB

Esculentoside A (EsA), a kind of triterpene saponin isolated from roots of Phytolacca esculenta . Esculentoside A (EsA) possesses anti-inflammatory activity in acute and chronic experimental models , has selective inhibitory activity towards cyclooxygenase-2 (COX-2) . Esculentoside A (EsA) suppresses inflammatory responses in LPS-induced acute lung injury (ALI) through inhibition of the nuclear factor kappa B (NF-ΚB) and mitogen activated protein kinase (MAPK) signaling pathways .
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2
Astragaloside II
Astragaloside II
0 Images
2 Cited Publications
Cat. No.: HY-N0433
CAS No.: 84676-89-1
Synonyms: Astrasieversianin VIII
Category:  

Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Extract Leguminosae/Fabaceae Extract Triterpenes Plant Terpenoids Other Diseases Disease Research Fields

Target:  

Autophagy Interleukin Related HIF/HIF Prolyl-Hydroxylase SOD NF-κB

Astragaloside II is an orally active Cycloartane-type triterpene glycoside. Astragaloside II can be extracted from Astragalus membranaceus. Astragaloside II inhibits Autophagy, decreases pro-inflammatory cytokines (IL-6, IL-1β), HIF-α, p-p65, p-IκB and increases SOD. Astragaloside II regulates immunity and reduces inflammatory responses. Astragaloside II can be used in the research of diseases such as liver cancer, osteoporosis, immunosuppressive diseases, and ulcerative colitis .
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