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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
31 Results for "
two-photon
" in MedChemExpress (MCE) Product Catalog:
Products (31)
31 Results for "two-photon" in MCE Product Catalog:
Cat. No.: HY-W017894
CAS No.: 84434-11-7
Cat. No.: HY-D2465
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CY5-Dextran (MW60-80k) is a fluorescent probe formed by covalent conjugation of the cyanine dye Cy5 to dextran. It is a pH-insensitive fluid-phase endocytosis tracer (the pH of endosomal lumen is precisely quantified by the fluorescence ratio of FITC/Cy5). CY5-Dextran (MW60-80k) is internalized by cells via a clathrin-independent fluid-phase pinocytosis pathway, and is sequentially evidenced by early endosomes, late endosomes are transported to lysosomes. CY5-D I cannot pass through the limited pore size formed by uncoating of human rhinovirus type 2 (HRV2), but can be released into the neutral cytoplasm upon adenovirus-mediated endosomal rupture, thus distinguishing between the two viral modes of "pore-forming escape" and "lysis escape". CY5-Dextran (MW60) -80k) has an excitation wavelength of 635 nm, and it can also be used for time-lapse imaging of endocytosis dynamics of stromal cells in tissues such as rat salivary glands under in vivo two-photon microscopy .
Cat. No.: HY-D2344
CAS No.: 325721-44-6
Synonyms: 3-Benzothiazole-daphnetin
Cat. No.: HY-D2971
CAS No.: 2781892-92-8
Cat. No.: HY-D1637
CAS No.: 172646-43-4
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5-Nitro BAPTA tetramethyl ester is a calcium chelator. 5-Nitro BAPTA tetramethyl ester involves in the two-photon probe synthesis, and is used for real-time imaging of intracellular calcium ions, calcium waves monitoring at a depth of 100-300 μm in liver tissues for 1100-4000 s. 5-Nitro BAPTA tetramethyl ester, together with fluorescent compound 2-Me-substituted TM, can be used to form a red fluorescent probe (CaTM-2 AM) .
Cat. No.: HY-139816
CAS No.: 2507992-93-8
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BTNPO is a unimolecular two-photon fluorescent probe.
Cat. No.: HY-136675
CAS No.: 1850419-05-4
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ASMI is a ratiometric, two-photon excited fluorescent probe, composed of a highly two-photon active and biocompatible merocyanine fluorophore and an acrylate moiety as a thiol reactive site. ASMI is able to selectively detect and monitor mitochondrial Cys with rapid responsiveness, imaging living cells and intact tissues with high contrast and brightness at a depth of 150 μm. The two-photon action cross section (Φσmax) of ASMI is 65.2 GM, corresponding to an excitation wavelength (λex) of 740 nm.
Cat. No.: HY-D1253
CAS No.: 2937819-61-7
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TP-TRFS is a highly selective and the first two-photon fluorescent probe of thioredoxin reductase (TrxR) .
Cat. No.: HY-D2968
CAS No.: 2759816-87-8
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DCM-ONOO is a near-infrared two-photon fluorescence probe specifically designed for real-time monitoring of the dynamic fluctuations of peroxynitrite (ONOO⁻) in epilepsy models. DCM-ONOO exhibits excellent optical properties, with a single photon excitation (Ex) of 520 nm; a single photon emission (Em) of 685 nm; a two-photon excitation of 820 nm; and a Stokes shift of 165 nm. When DCM-ONOO is combined with ONOO⁻, it shifts from 460 nm to 512 nm, and only generates a significant fluorescence response to ONOO⁻. DCM-ONOO has been successfully applied to rat epilepsy models .
Cat. No.: HY-D2474
CAS No.: 3030735-86-2
Cat. No.: HY-147915
CAS No.: 2416220-53-4
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Benz-AP is a potent photosensitizer. Benz-AP produces singlet oxygen, with a negative correlation with hCES2 (Human carboxylesterase 2) activity. Benz-AP displays a higher photocytotoxicity potency in cancer cells under low hCES2 environments. Upon TPE (Two-photon excitation), Benz-AP produces ROS and kills cancer cells and tumor spheroids .
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RuBi-Glutamate hexafluorophosphate sodium is a neuronal activator. RuBi-Glutamate hexafluorophosphate sodium photocleaves to release glutamate upon one- or two-photon excitation, activating glutamate receptors in cortical pyramidal neurons. RuBi-Glutamate hexafluorophosphate sodium reduces peak amplitude of evoked GABAergic inhibitory postsynaptic currents in its caged form. RuBi-Glutamate hexafluorophosphate sodium can be used for the research of Huntington's disease .
Cat. No.: HY-D3171
Cat. No.: HY-D3267
CAS No.: 1314527-28-0
Cat. No.: HY-161476
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Ir-ImNO is a mitochondria-targeted two-photon probe with excellent cell membrane permeability, capable of detecting both endogenous and exogenous cell membrane permeability. Ir-ImNO can monitor different immune response states of macrophages through various imaging techniques, including one-photon and two-photon phosphorescence imaging as well as phosphorescence lifetime imaging. Ir-ImNO can be utilized in the research to assist in the clinical monitoring of immunotherapy .
Cat. No.: HY-D3221
CAS No.: 1386860-79-2
Cat. No.: HY-D3087
CAS No.: 1966158-27-9
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Lyso-OC is a two-photon fluorescent probe that enables real-time monitoring of autophagy through ultrasensitive detection of lysosomal polarity changes. Lyso-OC possesses a coumarin (HY-N0709) solvatochromic group and a morpholine lysosome-targeting group, allowing selective lysosomal localization in living cells. Lyso-OC emits strong fluorescence in low-polarity lysosomes, whereas in high-polarity autolysosomes formed during autophagy, its fluorescence intensity decreases and the emission peak shifts by approximately 30 nm. For two-photon detection, the excitation/emission wavelengths of Lyso-OC are 760/490-550 nm, and its one-photon excitation wavelength is 375 nm. Lyso-OC can be used in cancer-related research .
Cat. No.: HY-D3073
CAS No.: 2477607-64-8
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DXB-NIR is a push-pull dioxaboron fluorescent probe with solvatochromic properties, featuring high fluorescence brightness, photostability, and a large two-photon absorption cross-section. DXB-NIR exhibits Ex/Em of 550/620–780 nm (with two-photon excitation at 930 nm). DXB-NIR quantifies local polarity via the intensity ratio I (>640)/I (<640) between the far-red channel (<640 nm) and the near-infrared channel (>640 nm), and it can simultaneously label the plasma membrane, endoplasmic reticulum, and lipid droplets in live cells. DXB-NIR monitors the increase in local polarity of various cell compartments under conditions of cholesterol depletion, starvation, and oxidative stress. DXB-NIR can be used for polarity imaging of biological membranes and lipid droplets, as well as studies related to cellular stress .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
