10

Brincidofovir

10 Publications Verification

Cat. No.: HY-14532

CAS No.: 444805-28-1

Purity: 99.46%

Synonyms: CMX001; HDP-CDV

Target:

CMV HSV Orthopoxvirus

Research Areas:

Infection

Brincidofovir (CMX001), the lipid-conjugated prodrug of Cidofovir (HY-17438), is an orally available, long-acting antiviral. Brincidofovir shows activity against a broad spectrum of DNA viruses including cytomegalovirus (CMV), adenovirus (ADV), varicella zoster virus, herpes simplex virus, polyomaviruses, papillomaviruses, poxviruses, and mixed double-stranded DNA virus infections. Brincidofovir, an oral antiviral in late stage development, has proven effective against orthopoxviruses in vitro and in vivo .

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8

Vidarabine

8 Cited Publications

Cat. No.: HY-B0277

CAS No.: 5536-17-4

Synonyms: Ara-A; Adenine Arabinoside; 9-β-D-Arabinofuranosyladenine

Category:

Infection Microorganisms Antibiotics Antiviral Disease Research Antibacterial Disease Research Fields

Target:

Nucleoside Antimetabolite/Analog DNA/RNA Synthesis HSV VZV CMV EBV

Vidarabine (Ara-A) is a Purine nucleoside derivative and Antiviral agent. The triphosphate derivative of Vidarabine competitively inhibits DNA polymerase, incorporates into the terminus of elongating DNA molecules, and interferes with the early steps of viral DNA synthesis. Vidarabine inhibits the replication of herpes simplex virus, varicella-zoster virus, cytomegalovirus, Epstein-Barr virus and vaccinia virus, reduces viral shedding, and accelerates skin healing. Vidarabine is metabolized to arabinosyl hypoxanthine, causes minimal impairment of corneal wound healing in rabbit models, and is associated with recurrence of herpes simplex encephalitis. Vidarabine can be used in the research of herpetic keratoconjunctivitis, herpes simplex encephalitis, herpetic uveitis, and chronic active hepatitis associated with hepatitis B virus .

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8

Vidarabine monohydrate

8 Cited Publications

Cat. No.: HY-N6666

CAS No.: 24356-66-9

Target:

Nucleoside Antimetabolite/Analog DNA/RNA Synthesis HSV VZV CMV EBV

Research Areas:

Infection

Vidarabine monohydrate is a Purine nucleoside derivative and Antiviral agent. The triphosphate derivative of Vidarabine monohydrate competitively inhibits DNA polymerase, incorporates into the terminus of elongating DNA molecules, and interferes with the early steps of viral DNA synthesis. Vidarabine monohydrate inhibits the replication of herpes simplex virus, varicella-zoster virus, cytomegalovirus, Epstein-Barr virus and vaccinia virus, reduces viral shedding, and accelerates skin healing. Vidarabine monohydrate is metabolized to arabinosyl hypoxanthine, causes minimal impairment of corneal wound healing in rabbit models, and is associated with recurrence of herpes simplex encephalitis. Vidarabine monohydrate can be used in the research of herpetic keratoconjunctivitis, herpes simplex encephalitis, herpetic uveitis, and chronic active hepatitis associated with hepatitis B virus .

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4

Larazotide acetate

4 Cited Publications

Cat. No.: HY-106268A

CAS No.: 881851-50-9

Purity: 99.74%

Target:

VZV Gap Junction Protein

Research Areas:

Inflammation/Immunology

Larazotide acetate is a peptide which is an orally active zonulin antagonist. Larazotide acetate shows antiviral activity to varicella-zoster virus (VZV) with EC₅₀s of 44.14 and 59.06 μM for strain OKA and 07-1, respectively. Larazotide acetate can be used for the research of celiac disease and infection.

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4

Larazotide

4 Cited Publications

Cat. No.: HY-106268

CAS No.: 258818-34-7

Purity: 98.20%

Target:

VZV Gap Junction Protein

Research Areas:

Infection Inflammation/Immunology

Larazotideis a peptide which is an orally active zonulin antagonist. Larazotide shows antiviral activity to varicella-zoster virus (VZV) with EC₅₀s of 44.14 and 59.06 μM for strain OKA and 07-1, respectively. Larazotide can be used for the research of celiac disease and infection .

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3

Oxyresveratrol

3 Cited Publications

Cat. No.: HY-N1430

CAS No.: 29700-22-9

Synonyms: trans-Oxyresveratrol

Category:

Stilbenes Anti-aging Other Diseases Phenols Polyphenols Plants Other Families Extract Disease Research Fields

Target:

Free Radical Scavengers Tyrosinase HSV Autophagy

Oxyresveratrol (trans-Oxyresveratrol) is a potent naturally occurring antioxidant and free radical scavenger (IC₅₀ of 28.9 μM against DPPH free radicals). Oxyresveratrol is potent and noncompetitive tyrosinase inhibitor with an IC₅₀ value of 1.2 μM for mushroom tyrosinase. Oxyresveratrol is effective against HSV-1, HSV-2 and varicella-zoster virus, and has neuroprotective effects .

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1

Moroxydine hydrochloride

1 Cited Publications

Cat. No.: HY-B0420A

CAS No.: 3160-91-6

Synonyms: ABOB hydrochloride

Target:

Influenza Virus HCV HSV Apoptosis Caspase

Research Areas:

Infection

Moroxydine (ABOB) hydrochloride is a broad-spectrum agent with multi-antiviral activities against DNA and RNA viruses, including influenza virus, herpes simplex, varicella zoster, measles, mumps disease, hepatitis C virus, etc. Moroxydine hydrochloride exhibits excellent antiviral activity and shows low cytotoxicity to cells infected by dsRNA viruses (grass carp reovirus, GCRV) and large DNA viruses (giant salamander iridovirus, GSIV). Moroxydine hydrochloride blocks the GCRV-induced cytopathic effects and eliminates nucleocapsids in ctenopharyngodon idella kidney (CIK) cells to keep the normal morphological structure. Moroxydine hydrochloride significantly inhibits the apoptosis, the caspase 3 activity, Bax expression and down-regulates Bcl-2 levels .

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PNU-183792

Cat. No.: HY-148852

CAS No.: 282536-25-8

Target:

HSV

Research Areas:

Infection

PNU-183792, a 4-oxo-dihydroquinoline, is an orally active HSV polymerases inhibitor. PNU-183792 shows a broad-spectrum antiviral activity, with IC₅₀ values of 0.69 μM, 0.37 μM and 0.58 μM for human cytomegalovirus (HCM), varicella zoster virus and HSV polymerases, respectively. PNU-183792 is inactive against human α, γ and δ polymerases. PNU-183792 also inhibits simian varicella virus (SVV), murine cytomegalovirus (MCMV) and rat cytomegalovirus (RCMV) .

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Acyclovir-d4

Cat. No.: HY-17422S1

CAS No.: 1185179-33-2

Synonyms: Aciclovir-d₄; Acycloguanosine-d₄

Acyclovir-d₄ is the deuterium labeled Acyclovir. Acyclovir (Aciclovir) is a guanosine analogue and an orally active antiviral agent. Acyclovir inhibits HSV-1 (IC₅₀ of 0.85 μM), HSV-2 (IC₅₀ of 0.86 μM) and varicella-zoster virus. Acyclovir can be phosphorylated by viral thymidine kinase (TK), and Acyclovir triphosphate interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate and obligatory chain termination . Acyclovir prevents bacterial infections during induction therapy for acute leukaemia .

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