29

PF-543

29 Publications Verification

Cat. No.: HY-15425

CAS No.: 1415562-82-1

Purity: 99.85%

Synonyms: Sphingosine Kinase 1 Inhibitor II

Target:

SphK LPL Receptor Apoptosis Autophagy

Research Areas:

Cardiovascular Disease Inflammation/Immunology Cancer

PF-543 (Sphingosine Kinase 1 Inhibitor II) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC₅₀ of 2 nM and a K_i of 3.6 nM. PF-543 is >100-fold selectivity for SPHK1 over SPHK2. PF-543 is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC₅₀ of 26.7 nM. PF-543 induces apoptosis, necrosis, and autophagy .

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29

PF-543 Citrate

29 Publications Verification

Cat. No.: HY-15425A

CAS No.: 1415562-83-2

Purity: 99.47%

Synonyms: Sphingosine Kinase 1 Inhibitor II Citrate

Target:

SphK LPL Receptor Apoptosis Autophagy

Research Areas:

Cardiovascular Disease Inflammation/Immunology Cancer

PF-543 Citrate (Sphingosine Kinase 1 Inhibitor II Citrate) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC₅₀ of 2 nM and a K_i of 3.6 nM. PF-543 Citrate is >100-fold selectivity for SPHK1 over SPHK2. PF-543 Citrate is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC₅₀ of 26.7 nM. PF-543 Citrate induces apoptosis, necrosis, and autophagy .

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21

GSH/GSSG Assay Kit

21 Cited Publications

Cat. No.: HY-K0311

MCE GSH/GSSG Assay Kit is suitable for the quantitative determination of reduced and oxidized glutathione (GSH/GSSG) in whole blood, plasma, serum, urine, and tissue and cell extracts.

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14

MK-886

14 Cited Publications

Cat. No.: HY-14166

CAS No.: 118414-82-7

Purity: 99.87%

Synonyms: L 663536

Target:

FLAP Leukotriene Receptor PPAR Apoptosis

Research Areas:

Cancer

MK-886 (L 663536) is a potent, cell-permeable and orally active FLAP (IC₅₀ of 30 nM) and leukotriene biosynthesis (IC₅₀s of 3 nM and 1.1 μM in intact leukocytes and human whole blood, respectively) inhibitor. MK-886 is also a non-competitive PPARα antagonist and can induce apoptosis .

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10

DPCPX

10 Cited Publications

Cat. No.: HY-100937

CAS No.: 102146-07-6

Purity: 99.96%

Synonyms: PD 116948

Target:

Adenosine Receptor

Research Areas:

Cardiovascular Disease

DPCPX (PD 116948), a xanthine derivative, is a highly potent and selective Adenosine A1 receptor antagonist, with a K_i of 0.46 nM in ³H-CHA binding to A1 receptors in rat whole brain membranes .

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6

Hydroxyprogesterone caproate

6 Cited Publications

Cat. No.: HY-B0742

CAS No.: 630-56-8

Synonyms: 17α-Hydroxyprogesterone hexanoate; 17α-Hydroxyprogesterone caproate

Target:

Progesterone Receptor

Research Areas:

Endocrinology

Hydroxyprogesterone caproate (17α-Hydroxyprogesterone hexanoate; 17α-Hydroxyprogesterone caproate) is a progesterone receptor (progesterone receptor) ligand and steroid hormone transcription inhibitor. Hydroxyprogesterone caproate downregulates estrogen receptors in target tissues and activates their metabolic pathways, and exhibits equivalent affinity for progesterone receptor A and progesterone receptor B. Hydroxyprogesterone caproate shows no consistent teratogenicity or developmental toxicity in rat, mouse and monkey models, but induces resorption or abortion in rhesus monkeys at human-equivalent doses. Hydroxyprogesterone caproate promotes the production of TNF-α in lipopolysaccharide-stimulated whole blood from non-pregnant women. Hydroxyprogesterone caproate can be used in scientific research related to preterm birth .

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5

PF-8380

5 Cited Publications

Cat. No.: HY-13344

CAS No.: 1144035-53-9

Purity: 99.05%

Target:

Phosphodiesterase (PDE)

Research Areas:

Inflammation/Immunology Cancer

PF-8380 is a potent autotaxin inhibitor with an IC₅₀ of 2.8 nM in isolated enzyme assay and 101 nM in human whole blood.

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5

Gliclazide

5 Cited Publications

Cat. No.: HY-B0753

CAS No.: 21187-98-4

Synonyms: S1702; SE1702

Target:

Potassium Channel

Research Areas:

Cardiovascular Disease

Gliclazide (S1702) is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC₅₀ of 184 nM. Gliclazide is used as an antidiabetic .

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5

PF-8380 hydrochloride

5 Cited Publications

Cat. No.: HY-13344A

CAS No.: 2070015-01-7

Purity: 98.59%

Target:

Phosphodiesterase (PDE)

Research Areas:

Inflammation/Immunology Cancer

PF-8380 hydrochloride is a potent autotaxin inhibitor with an IC₅₀ of 2.8 nM in isolated enzyme assay and 101 nM in human whole blood.

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3

Cot inhibitor-2

3 Cited Publications

Cat. No.: HY-32018

CAS No.: 915363-56-3

Target:

MAP3K

Research Areas:

Cancer

Cot inhibitor-2 is a potent, selective and orally active cot (Tpl2/MAP3K8) inhibitor with an IC₅₀ of 1.6 nM. Cot inhibitor-2 inhibts TNF-α production in LPS-stimulated human whole blood with an IC₅₀ of 0.3 μM .

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3

NAZ2329

3 Cited Publications

Cat. No.: HY-103693

CAS No.: 2809469-05-2

Purity: 99.02%

Target:

Phosphatase

Research Areas:

Cancer

NAZ2329, the first cell-permeable inhibitor of R5 subfamily of receptor-type protein tyrosine phosphatases (RPTPs), allosterically and preferentially inhibits PTPRZ (IC₅₀=7.5 µM for hPTPRZ1) and PTPRG (IC₅₀=4.8 µM for hPTPRG) over other PTPs. NAZ2329 binds to the active D1 domain and more potently inhibits PTPRZ-D1 fragment (IC₅₀ of 1.1 µM) than the whole intracellular (D1 + D2) fragment (IC₅₀ of 7.5 µM). NAZ2329 can effectively inhibit tumor growth of the glioblastoma cells and suppress stem cell-like properties .

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2

Cot inhibitor-1

2 Cited Publications

Cat. No.: HY-32015

CAS No.: 915365-57-0

Target:

MAP3K

Research Areas:

Inflammation/Immunology

Cot inhibitor-1 (compound 28) is a selective tumor progression loci-2 (Tpl2) kinase inhibitor with an IC₅₀ of 28 nM. Cot inhibitor-1 shows an inhibition of TNF-alpha production in human whole blood with an IC₅₀ of 5.7 nM .

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2

GSK620

2 Cited Publications

Cat. No.: HY-137892

CAS No.: 2088410-46-0

Purity: 99.79%

Target:

Epigenetic Reader Domain

Research Areas:

Inflammation/Immunology

GSK620, a chemical probe, is a potent and orally active pan-BD2 inhibitor with excellent broad selectivity, developability and in vivo oral pharmacokinetics. GSK620 is highly selective for the BET-BD2 family of proteins, with >200-fold selectivity over all other bromodomains. GSK620 shows an anti-inflammatory phenotype in human whole blood .

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