2229 Results for "

xidative damage

" in MedChemExpress (MCE) Product Catalog:
Products (2229)

2229 Results for "xidative damage" in MCE Product Catalog:

1851
Ferrostatin-1
Ferrostatin-1
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1851 Publications Verification
Cat. No.: HY-100579
CAS No.: 347174-05-4
Purity:  99.71%
Synonyms: Fer-1
Target:  

Ferroptosis Fungal

Research Areas:  

Cancer

Ferrostatin-1 (Fer-1), a potent and selective ferroptosis inhibitor, suppresses Erastin-induced ferroptosis in HT-1080 cells (EC50=60 nM). Ferrostatin-1, a synthetic antioxidant, acts via a reductive mechanism to prevent damage to membrane lipids and thereby inhibits cell death. Ferrostatin-1 exhibits antifungal activity .
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899
Cisplatin
Cisplatin
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899 Cited Publications
Cat. No.: HY-17394
CAS No.: 15663-27-1
Synonyms: cis-Platinum; CDDP; cis-Diaminodichloroplatinum
Target:  

DNA Alkylator/Crosslinker Ferroptosis Autophagy Pyroptosis Lipoxygenase

Research Areas:  

Cancer

Cisplatin (CDDP) is an antineoplastic chemotherapy agent by cross-linking with DNA and causing DNA damage in cancer cells. Cisplatin activates ferroptosis and induces autophagy .
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245
Oxaliplatin
Oxaliplatin
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245 Cited Publications
Cat. No.: HY-17371
CAS No.: 61825-94-3
Target:  

DNA/RNA Synthesis Apoptosis

Research Areas:  

Inflammation/Immunology Cancer

Oxaliplatin is a DNA synthesis inhibitor. Oxaliplatin causes DNA crosslinking damage, prevents DNA replication and transcription and induces apoptosis. Oxaliplatin can be used for cancer research .
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226
Bleomycin hydrochloride
Bleomycin hydrochloride
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226 Cited Publications
Cat. No.: HY-17565A
CAS No.: 67763-87-5
Target:  

DNA/RNA Synthesis Antibiotic

Research Areas:  

Cancer

Bleomycin hydrochloride is a DNA synthesis inhibitor. Bleomycin hydrochloride is a DNA damaging agent. Bleomycin hydrochloride is an antitumor antibiotic .
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226
Bleomycin sulfate
Bleomycin sulfate
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226 Cited Publications
Cat. No.: HY-17565
CAS No.: 9041-93-4
Synonyms: Bleomycin sulfate
Category:  

Microorganisms Antibiotics Resistance Selection Mammalian Cell Culture Disease Research Anticancer Disease Research Fields Other Antibiotics Cancer

Target:  

DNA/RNA Synthesis Antibiotic

Bleomycin sulfate is a DNA synthesis inhibitor. Bleomycin hydrochloride is a DNA damaging agent. Bleomycin sulfate is an antitumor antibiotic .
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191
DAPI dihydrochloride
DAPI dihydrochloride
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191 Cited Publications
Cat. No.: HY-D0814
CAS No.: 28718-90-3
Synonyms: 4',6-Diamidino-2-phenylindole dihydrochloride
DAPI (4',6-Diamidino-2-phenylindole) dihydrochloride is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. DAPI cannot penetrate intact cell membranes and is commonly used for staining damaged and fixed cells . DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment (Ex/Em = 356/451 nm).
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191
DAPI
DAPI
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191 Cited Publications
Cat. No.: HY-D2868
CAS No.: 47165-04-8
Synonyms: 4',6-Diamidino-2-phenylindole
DAPI (4',6-Diamidino-2-phenylindole) is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. DAPI cannot penetrate intact cell membranes and is commonly used for staining damaged and fixed cells . DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment (Ex/Em = 356/451 nm).
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185
DAPI dilactate
DAPI dilactate
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185 Cited Publications
Cat. No.: HY-D1738
CAS No.: 28718-91-4
Synonyms: 4',6-Diamidino-2-phenylindole dilactate
DAPI (4',6-Diamidino-2-phenylindole) dilactate is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. DAPI cannot penetrate intact cell membranes and is commonly used for staining damaged and fixed cells . DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment (Ex/Em = 356/451 nm) .
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172
Propidium Iodide
Propidium Iodide
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172 Cited Publications
Cat. No.: HY-D0815
CAS No.: 25535-16-4
Propidium Iodide (PI) is a nuclear staining agent that stains DNA. Propidium Iodide is an analogue of ethidine bromide that emits red fluorescence upon embedding in double-stranded DNA. Propidium Iodide cannot pass through living cell membranes, but it can pass through damaged cell membranes to stain the nucleus. Propidium Iodide has a fluorescence wavelength of 493/617 nm and a wavelength of 536/635 nm after Mosaic with DNA. Propidium Iodide is commonly used in the detection of apoptosis (apoptosis) or necrosis (necrosis), and is often used in flow cytometry analysis.
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168
Mitoquinone mesylate
Mitoquinone mesylate
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168 Cited Publications
Cat. No.: HY-100116A
CAS No.: 845959-50-4
Purity:  99.09%
Synonyms: MitoQ mesylate; MitoQ10 mesylate
Target:  

Reactive Oxygen Species (ROS)

Research Areas:  

Metabolic Disease Cancer

Mitoquinone mesylate is a TPP-based, mitochondrially targeted antioxidant in order to protect against oxidative damage .
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154
Necrosulfonamide
Necrosulfonamide
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154 Cited Publications
Cat. No.: HY-100573
CAS No.: 1360614-48-7
Purity:  99.47%
Target:  

Mixed Lineage Kinase Necroptosis Pyroptosis Caspase NOD-like Receptor (NLR) Keap1-Nrf2 TNF Receptor Interleukin Related NO Synthase Heme Oxygenase (HO)

Research Areas:  

Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology

Necrosulfonamide is a MLKL and Gasdermin D (GSDMD) inhibitor, capable of separately inhibiting necroptosis and pyroptosis of cells. Necrosulfonamide does not affect the activation of upstream signals, but specifically inhibits the downstream executor oligomerization step. Necrosulfonamide reduces the expression of the key kinases NLRP3 and caspase-1 involved in necroptosis and pyroptosis, activate the Nrf2 pathway and the downstream antioxidant enzymes, and also downregulates a variety of inflammatory factors. Necrosulfonamide plays significant roles in various diseases such as neurodegenerative diseases (such as Parkinson’s disease), tissue damage and ischemia-reperfusion injury, inflammatory bowel disease, osteoarthritis and fracture repair, and hair loss by regulating two important programmed necrosis pathways .
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122
PX-478
PX-478
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122 Cited Publications
Cat. No.: HY-10231
CAS No.: 685898-44-6
Purity:  ≥98.0%
Target:  

HIF/HIF Prolyl-Hydroxylase VEGFR Autophagy

Research Areas:  

Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer

PX-478 is a multifunctional HIF-1α inhibitor with properties including radiosensitization, autophagy activation, and lipid accumulation inhibition. PX-478 also blocks hypoxia-induced VEGF production and regulates β-cell phenotypes under hypoxic conditions. PX-478 induces cell cycle arrest and DNA damage, restores autophagic function, reduces foam cell formation, and maintains glucose homeostasis. PX-478 is widely used in research on related diseases such as human tumors (e.g., prostate cancer), type 2 diabetes, and atherosclerosis .
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114
Tauroursodeoxycholate dihydrate
Tauroursodeoxycholate dihydrate
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114 Cited Publications
Cat. No.: HY-19696B
CAS No.: 117609-50-4
Synonyms: Tauroursodeoxycholic acid dihydrate; TUDCA dihydrate; UR 906 dihydrate
Category:  

Endogenous metabolite Disease Research Fields Cancer Steroids

Target:  

Caspase Apoptosis Endogenous Metabolite IRE1 NF-κB JNK Reactive Oxygen Species (ROS) Akt

Tauroursodeoxycholate dehydrate is an orally active taurine conjugate of Ursodeoxycholic acid (HY-13771). Tauroursodeoxycholate dehydrate inhibits caspase-3/7, Apoptosis, IRE1α/TRAF2/NF-κB, prevents JNK phosphorylation, inhibits ROS generation, and activates Akt signaling. Tauroursodeoxycholate dehydrate prevents cataract formation, reduces renal tubular damage in type 2 diabetic mice, reduces I/R injury in liver, and inhibits intestinal inflammation and barrier disruption in nonalcoholic fatty liver disease .
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102
FITC-Dextran (MW 10000)
FITC-Dextran (MW 10000)
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102 Cited Publications
Cat. No.: HY-128868
CAS No.: 60842-46-8
FITC-Dextran (MW 10000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 10000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 10000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption .
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102
FITC-Dextran (MW 4000)
FITC-Dextran (MW 4000)
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102 Cited Publications
Cat. No.: HY-128868A
CAS No.: 60842-46-8
FITC-Dextran (MW 4000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 4000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 4000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption .
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92
L-Ascorbic acid
L-Ascorbic acid
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92 Cited Publications
Cat. No.: HY-B0166
CAS No.: 50-81-7
Synonyms: L-Ascorbate; Vitamin C
Category:  

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