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Cat. No.: HY-164132

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Silodosin Glucuronide

Name: Silodosin Glucuronide
Brand: MedChemExpress
SKU: HY-164132
Availability: PreOrder

(Synonyms: Silodosin β-D-glucuronide; KMD-3213G)

Silodosin Glucuronide (Silodosin β-D-glucuronide; KMD-3213G) is generated in vivo via glucuronidation of the α1A-adrenoceptor antagonist Silodosin (HY-10122). Silodosin Glucuronide is a key biomarker measured simultaneously with the parent drug in human pharmacokinetic/bioequivalence studies of Silodosin formulations.

For research use only. We do not sell to patients.

CAS No.: 879396-70-0
Formula: C₃₁H₄₀F₃N₃O₁₀
Molecular Weight:671.66

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Silodosin Glucuronide Chemical Structure

CAS No.: 879396-70-0

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Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

Silodosin Glucuronide (Silodosin β-D-glucuronide; KMD-3213G) is the primary metabolite generated from extensive glucuronidation of Silodosin, possesses α1A receptor-related activity, has an elimination half-life of approximately 24 h, and its AUC is approximately 4 times that of the parent drug Silodosin^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 879396-70-0
Molecular Weight 671.66
Formula C₃₁H₄₀F₃N₃O₁₀
SMILES

OC([C@H]([C@H]([C@@H]([C@H]1O)O)O)O[C@H]1OCCCN2C3=C(C(N)=O)C=C(C[C@@H](C)NCCOC4=C(OCC(F)(F)F)C=CC=C4)C=C3CC2)=O
Synonyms

Silodosin β-D-glucuronide; KMD-3213G
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Shah PA, et al. Determination of silodosin and its active glucuronide metabolite KMD-3213G in human plasma by LC-MS/MS for a bioequivalence study. Biomedical chromatography : BMC. 2018 Feb;32(2).

[2]. Schilit S, et al. Silodosin: A Selective α1A-Adrenergic Receptor Antagonist for the Treatment of Benign Prostatic Hyperplasia. Clinical Therapeutics. 2009, 31 (11): 2310-2322.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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