Sodium malonate
Based on 1 Customer Validation
Sodium malonate is an inhibitor of succinate dehydrogenase (SDH) and can interfere with the TCA cycle. Sodium malonate can act as an AcrAB‑TolC efflux pump inhibitor, blocking multidrug efflux processes in bacteria and enhancing the efficacy of antibiotics. Sodium malonate can be converted to malonyl‑CoA, which mediates protein lysine malonylation, relieves the transcriptional repression effect of STAT6, upregulates TCF1 protein expression, and thereby promotes CD8+ T cell memory differentiation. Sodium malonate can stimulate ovarian steroidogenesis in immature rats, increasing ovarian and uterine weights and ovarian cholesterol production. Sodium malonate can inhibit brain ATP production, leading to energy deficiency, neuronal glutamate accumulation, and excitotoxic striatal lesions. Sodium malonate can be used in research on metabolism-related diseases, immune-related diseases, and bacterial infections, and can also serve as an intermediate for research related to organic synthesis.
For research use only. We do not sell to patients.
- Purity : 98.0%
- CAS No.: 141-95-7
- Formula: C3H2Na2O4
- Molecular Weight:148.03
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
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Human Endogenous Metabolite |
In Vitro
Sodium malonate (1 M; 18 h) has an MIC of 1 M against E. coli BW25113 and CR5000, and at 100 mM it enhances the efficacy of EtBr, Minocycline (HY-17412A), Chloramphenicol (HY-B0239), and Ciprofloxacin (HY-B0356)[4].
Sodium malonate (25 mM) reduces the MIC of EtBr in E. coli BW25113 by two-fold at 25-50 mM and by four-fold at 100 mM, from 1000 µM to 250 µM[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Albino (female, sexually immature, 40-45 g)[6]
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Dosage:80 mg/100 g body weight in 0.9% NaCl
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Administration:i.p.; once daily; 10 days
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Result:Stimulated ovarian steroidogenesis in immature rats, increasing ovarian and uterine weights and ovarian cholesterol while depleting ovarian ascorbic acid.
Chemical Information
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CAS No. 141-95-7
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Appearance Solid
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Molecular Weight 148.03
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Formula C3H2Na2O4
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Color White to off-white
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SMILES
O=C([O-])CC([O-])=O.[Na+].[Na+]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
H2O : 350 mg/mL (2364.39 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (294 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 6.7554 mL | 33.7769 mL | 67.5539 mL | 168.8847 mL |
| 5 mM | 1.3511 mL | 6.7554 mL | 13.5108 mL | 33.7769 mL | |
| 10 mM | 0.6755 mL | 3.3777 mL | 6.7554 mL | 16.8885 mL | |
| 15 mM | 0.4504 mL | 2.2518 mL | 4.5036 mL | 11.2590 mL | |
| 20 mM | 0.3378 mL | 1.6888 mL | 3.3777 mL | 8.4442 mL | |
| 25 mM | 0.2702 mL | 1.3511 mL | 2.7022 mL | 6.7554 mL | |
| 30 mM | 0.2252 mL | 1.1259 mL | 2.2518 mL | 5.6295 mL | |
| 40 mM | 0.1689 mL | 0.8444 mL | 1.6888 mL | 4.2221 mL | |
| 50 mM | 0.1351 mL | 0.6755 mL | 1.3511 mL | 3.3777 mL | |
| 60 mM | 0.1126 mL | 0.5629 mL | 1.1259 mL | 2.8147 mL | |
| 80 mM | 0.0844 mL | 0.4222 mL | 0.8444 mL | 2.1111 mL | |
| 100 mM | 0.0676 mL | 0.3378 mL | 0.6755 mL | 1.6888 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Sodium malonate Related Classifications
HY-W283726 Related Classifications
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