SQ-030
SQ-030 is a cPGES inhibitor with a human Kd of 0.315 μM. SQ-030 reduces lipid accumulation in hepatocytes. SQ-030 ameliorates hepatic dysfunction, hepatic steatosis, inflammation, and fibrosis in mice. SQ-030 alleviates hepatic dysfunction and lipid deposition in mice. SQ-030 can be used for research on metabolic dysfunction-associated steatotic liver disease (MASLD).
For research use only. We do not sell to patients.
- CAS No.: 667880-05-9
- Formula: C21H21N3O5
- Molecular Weight:395.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J (male)[1]
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Dosage:1 mg/kg
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Administration:i.p.; every other day; for 4 weeks
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Result:Alleviated liver dysfunction (serum AST and ALT), hepatic steatosis, inflammation, and fibrosis.
Relative NAS was lower in SQ-030-treated MCD mice than in controls.
Did not change hepatic PGE2 levels or mRNA expression of the four EP receptors (Ptger1-4).
- Fibrosis/Collagen Morphometry
- 3T3-L1 preadipocyte-to-adipocyte differentiation
- Collagen: Sirius Red Staining
- Connective Tissue: Masson's Trichrome/Collagen Trichrome Staining
- Research Protocol for Inflammation-related Diseases
- Lipid Droplets: Oil Red O/Sudan Dye Lipid Staining
- Liver Histomorphometry
Chemical Information
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CAS No. 667880-05-9
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Molecular Weight 395.41
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Formula C21H21N3O5
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SMILES
CC1=C(C(OC)=O)C(C2=CC=C(OCC(NC3=CC=CC=C3)=O)C=C2)NC(N1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SQ-030 Related Classifications
HY-189759 Related Classifications
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