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Cat. No.: HY-190173

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WEE1 degrader-2

WEE1 degrader-2 is a Wee1 molecular glue degrader. WEE1 degrader-2 induces ubiquitination and degradation of Wee1 kinase by recruiting the CRBN E3 ubiquitin ligase complex. WEE1 degrader-2 degrades Wee1 protein in tumor cells. WEE1 degrader-2 can be used in research related to acute lymphoblastic leukemia and glioblastoma.

For research use only. We do not sell to patients.

CAS No.: 2618349-09-8
Formula: C₂₀H₁₄F₃N₃O₄
Molecular Weight:417.34

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

WEE1 degrader-2 Chemical Structure

CAS No.: 2618349-09-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Wee1 Isoforms :

PKMYT1

In Vitro

Cell Cycle Regulation

WEE1 degrader-2 (Compound WX002) (10 μM; 4 h) promotes the degradation of Wee1 in MOLT-4 cells^[1].
WEE1 degrader-2 (1 μM; 24 h) promotes the degradation of Wee1 in U87-MG cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

MOLT-4 cells
Concentration:

10 μM
Incubation Time:

4 h
Result:

Promoted Wee1 degradation in MOLT-4 cells.

Western Blot Analysis^[1]

Cell Line:

U87-MG cells
Concentration:

1 μM
Incubation Time:

24 h
Result:

Promoted Wee1 degradation in U87-MG cells.

Chemical Information

CAS No. 2618349-09-8
Molecular Weight 417.34
Formula C₂₀H₁₄F₃N₃O₄
SMILES

O=C(N1)CCC(C2=COC3=C2C=C(NC(C4=CC(C(F)(F)F)=NC=C4)=O)C=C3)C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Luo Y, et al. Fused cyclic compound capable of degrading protein and use thereof. WO2021047627A1, 2021.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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