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Cat. No.: HY-N21936

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Wollamide B

Wollamide B is a naturally occurring cyclic hexapeptide with antimycobacterial activity. Wollamide B inhibits the proliferation of extracellular and intramacrophage Mycobacterium tuberculosis. Wollamide B exhibits cytotoxicity against human tumor cell lines. Wollamide B can be used in research related to bacterial infections.

For research use only. We do not sell to patients.

CAS No.: 1628612-29-2
Formula: C₃₇H₅₇N₉O₇
Molecular Weight:739.90

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Wollamide B Chemical Structure

CAS No.: 1628612-29-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HEp-2	IC50	50.1 μM	Cytotoxicity against human Hep2G cells. Cytotoxicity against human Hep2G cells.	30031620
MCF7	IC50	115.4 μM	Cytotoxicity against human MCF-7 cells measured as IC50. Cytotoxicity against human MCF-7 cells measured as IC50.	29125222
HepG2	IC50	79.2 μM	Cytotoxicity against human HepG-2 cells measured as IC50. Cytotoxicity against human HepG-2 cells measured as IC50.	29125222

In Vitro

OthersBacterial InfectionAnti-cancer

Others

Wollamide B is proposed to be a de novo synthesized antimicrobial peptide in untargeted LC-MS metabolomics analysis^[1].
Wollamide B exhibits an IC₅₀ of 50.1 μM against human Hep2G cells^[2].
Wollamide B exhibits passive artificial‑membrane permeability of < 6.5 nm/s^[2].

Wollamide B shows human microsomal clearance of 0.97 mL/min/g tissue^[2].

Bacterial Infection

Wollamide B (compound 4c) exhibits potent extracellular activity against Mtb H37Rv with an MIC of 0.6 μM, and displays intracellular activity against Mtb H37Rv in human macrophages with an IC₅₀ of 1.3 μM^[2].
Wollamide B exhibits antibacterial activity against MRSA2, MRSA4, and MRSA5 strains with an MIC value of 32 μg/mL, against Staphylococcus aureus ATCC 25923 with an MIC value of 64 μg/mL, against Salmonella typhimurium CMCC 50097 and Klebsiella peneumoniae ATCC 13883 with an MIC value of 128 μg/mL, and against Escherichia coli ATCC 25922 with an MIC value of 64 μg/mL^[3].

Anti-cancer

Wollamide B (WO-2) exhibits low cytotoxicity against MCF-7 and HepG-2 cell lines, with IC₅₀ values of 115.4 μM and 79.2 μM, respectively^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 1628612-29-2
Molecular Weight 739.90
Formula C₃₇H₅₇N₉O₇
SMILES

O=C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@H](C(N[C@@H](C(N1)=O)CCCN)=O)CC(N)=O)=O)C(C)C)=O)CC(C)C)=O)CC(C)C)[C@@H]1CC2=CNC3=CC=CC=C23
Sequence

Cyclo(Trp-Leu-{d-Leu}-Val-Asn-Orn)
Sequence Shortening

Cyclo(WL-{d-Leu}-VNO)
Structure Classification
- Cyclopeptides
Initial Source
- Microorganisms
Streptomyces nov. sp. MST-115088
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Malekian A, et al. Immune priming reprograms the maggot secretome to enhance anti-Leishmania activity. Scientific Reports. 2026 Sep 10.

[2]. Asfaw H, et al. An efficient synthetic route for preparation of antimycobacterial wollamides and evaluation of their in vitro and in vivo efficacy. Bioorganic & medicinal chemistry letters. 2018 Sep 15;28(17):2899-2905.

[3]. Chen YX, et al. Total Synthesis and Antibacterial Study of Cyclohexapeptides Desotamide B, Wollamide B and Their Analogs. Chemistry & biodiversity. 2018 Jan;15(1).

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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