CXCR Ligand
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SDF-1α (human) TFA
0 ImagesCat. No.: HY-P4911APurity: 98.89%SDF-1α (human) TFA is an endogenous CXC chemokine and the primary natural ligand of CXCR4. SDF-1α (human) TFA activates Gαi, MAP kinase, β-arrestin, and JAK/STAT signaling pathways, promoting chemotaxis of CXCR4-positive cells. SDF-1α (human) TFA induces receptor internalization and promotes cancer cell migration and invasion. SDF-1α (human) TFA promotes dental pulp cell migration and is required for osteogenesis, angiogenesis, and neurogenesis of dental pulp cells. SDF-1α (human) TFA is used in research on CXCR4-mediated diseases, such as cancer and cardiovascular diseases.
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Cyclam
0 ImagesCyclam is a macrocyclic polyamine that can serve as a high-affinity chelator for Cu2+ and a CXCR4-targeting motif. Cyclam is the CXCR4-binding unit of the CXCR4 antagonist Plerixafor (AMD3100) (HY-10046). Cyclam-based macrocyclic compounds possess anti-HIV activity and can mobilize stem cells from the bone marrow. Cyclam can be used in research on ovarian cancer with high CXCR4 expression, as well as in the development of Cu2+ sensors and lanthanide luminescent bioprobes.
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SDF-1α (human)
0 ImagesCat. No.: HY-P4911CAS No.: 1268129-65-2SDF-1α (human) is an endogenous CXC chemokine and the primary natural ligand of CXCR4. SDF-1α (human) activates Gαi, MAP kinase, β-arrestin, and JAK/STAT signaling pathways, promoting chemotaxis of CXCR4-positive cells. SDF-1α (human) induces receptor internalization and promotes cancer cell migration and invasion. SDF-1α (human) promotes dental pulp cell migration and is required for osteogenesis, angiogenesis, and neurogenesis of dental pulp cells. SDF-1α (human) is used in research on CXCR4-mediated diseases, such as cancer and cardiovascular diseases.
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SDNUM04
0 ImagesCat. No.: HY-175882CAS No.: 3113549-20-2SDNUM04 is a C-X-C chemokine receptor 4 (CXCR4) ligand and can be used as a tracer in tumor-targeting studies.
