2201048-82-8
2201048-82-8
Chemical Structure
Zagociguat
Synonym(s): CY-6463; IW-6463
- CAS No.: 2201048-82-8
- Formula:C16H10F4N6
- Molecular Weight:362.28
IUPAC Name: 8-(2-fluorobenzyl)-6-(5-(trifluoromethyl)-4H-1,2,4-triazol-3-yl)imidazo[1,2-a]pyrazine
InChIKey: GTKNNCQKFKGSHR-UHFFFAOYSA-N
SMILES: FC1=C(CC2=NC(C3=NN=C(C(F)(F)F)N3)=CN4C=CN=C24)C=CC=C1
Biological Activity: Zagociguat (CY-6463) is an orally active and BBB-permeable soluble guanylate cyclase (sGC) stimulator. Zagociguat can increase cGMP levels, regulate blood pressure, improve neuronal function, reduce inflammatory responses, and exert neuroprotective and cognitive-improving effects. Zagociguat can be used in the research of neurodegenerative diseases[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Zagociguat | 99.09% | Zagociguat (CY-6463) is an orally active and BBB-permeable soluble guanylate cyclase (sGC) stimulator. Zagociguat can increase cGMP levels, regulate blood pressure, improve neuronal function, reduce inflammatory responses, and exert neuroprotective and cognitive-improving effects. Zagociguat can be used in the research of neurodegenerative diseases. | ||||||||||||||||||||
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R-7050 | 99.96% | R-7050 (TNF-α Antagonist III) is a tumor necrosis factor receptor (TNFR) antagonist with greater selectivity toward TNFα. | ||||||||||||||||||||
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TGFβRI-IN-6 | TGFβRI-IN-6 (compound 22) is a potent TGFβRI inhibitor with an IC50 value of 0.55 nM. TGFβRI-IN-6 has the potential to enhance anti-tumor immunity. | |||||||||||||||||||||
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TNF-α-IN-19 | 99.9% | TNF-α-IN-19 is an inhibitor of TNFα that can block the interaction between TNFαRI, TRADD, and RIP1, the EC50 values for TNFα, IL-1β, and IL-1β/TNFα are 2.451, 3.792 and 1.54 μM, respectively. TNF-α-IN-19 only inhibits the degradation of IκBα when cells are stimulated by TNFα and not by IL-1β. | ||||||||||||||||||||
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5M038 | 5M038 is an inhibitor of HIV envelope-mediated fusion with potent inhibitory activity against gp41-mediated membrane fusion. 5M038 prevents the formation of the gp41 post-fusion conformation and inhibits envelope-mediated membrane fusion in cell-cell fusion and viral infectivity assays. 5M038 has shown broad fusion inhibition in tests against multiple HIV-1 subtypes, including M and T strains. 5M038 targets a highly conserved hydrophobic pocket and binds to the gp41 trimer, thereby exerting its inhibitory effect. | |||||||||||||||||||||
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BRD4 Inhibitor-27 | BRD4 Inhibitor-27 (compound 6) is a BRD4 inhibitor with IC50 of 9.6 and 11.3 μM for BRD4 BD1 and BRD4 BD2, respectively. BRD4 Inhibitor-27 has the potential to study cancer. | |||||||||||||||||||||
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CK1δ-IN-10 | CK1δ-IN-10 (Compound 85) is the inhibitor for casein kinase 1 that inhibits CK1δ (CSNKID) with IC50 of 0.255 μM. | |||||||||||||||||||||
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Zaladenant | Zaladenant is an adenosine receptor antagonist with antitumor effects. | |||||||||||||||||||||
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cGAS-IN-6 | cGAS-IN-6 (14) is a cGAS inhibitor. cGAS-IN-6’s core structure is a fused imidazole ring system. cGAS-IN-6 can be used for research on autoimmune conditions. | |||||||||||||||||||||
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RO8191 | 98.80% | RO8191 (CDM-3008), an imidazonaphthyridine compound, is an orally active and potent interferon (IFN) receptor agonist. RO8191 directly binds to IFNα/β receptor 2 (IFNAR2) and activates IFN-stimulated genes (ISGs) expression and JAK/STAT phosphorylation. RO8191 shows antiviral activity against both HCV and EMCV with an IC50 of 200 nM for HCV replicon. RO8191 is a cccDNA modulator (CDM) through interferon-like activity and has anti-HBV activity. | ||||||||||||||||||||
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1,4-Bis(5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)butane | 1,4-Bis(5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)butane is a metal-organic framework (MOF). | |||||||||||||||||||||
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References
- [1]. Correia SS, et al. The CNS-Penetrant Soluble Guanylate Cyclase Stimulator CY6463 Reveals its Therapeutic Potential in Neurodegenerative Diseases. Front Pharmacol. 2021 May 24;12:656561. [Content Brief]
- [2]. Debra J. Wallace, et al. Accelerated Development of a Scalable Synthesis of CY6463, a CNS-Penetrant sGC Stimulator for the Treatment of Neurodegenerative Diseases. Org Process Res Dev. 2021;25(10):2288-2299.
