2757286-41-0
Chemical Structure
SARS-CoV-2-IN-123
- CAS No.: 2757286-41-0
- Formula:C21H16ClN3O2
- Molecular Weight:377.82
InChIKey: XQFMLNUPNCXPRN-UHFFFAOYSA-N
SMILES: O=C1NC2(CC(C2)C3=C(Cl)C=CC=C3)C(N1C4=CN=CC5=CC=CC=C54)=O
Biological Activity: SARS-CoV-2-IN-123 is a selective SARS-CoV-2 main protease (Mpro) inhibitor with an IC50 of 77 nM and a Kd of 38 nM. SARS-CoV-2-IN-123 exerts its inhibitory effect by blocking the polyprotein processing required for coronavirus replication, and its mechanism of action is independent of covalent cysteine modification or colloidal aggregation. SARS-CoV-2-IN-123 shows broad-spectrum antiviral activity in infected cells, along with favorable metabolic stability, plasma protein binding, and high Caco-2 permeability. SARS-CoV-2-IN-123 can be used for research related to coronavirus infection[1].
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SARS-CoV-2-IN-123 | SARS-CoV-2-IN-123 is a selective SARS-CoV-2 main protease (Mpro) inhibitor with an IC50 of 77 nM and a Kd of 38 nM. SARS-CoV-2-IN-123 exerts its inhibitory effect by blocking the polyprotein processing required for coronavirus replication, and its mechanism of action is independent of covalent cysteine modification or colloidal aggregation. SARS-CoV-2-IN-123 shows broad-spectrum antiviral activity in infected cells, along with favorable metabolic stability, plasma protein binding, and high Caco-2 permeability. SARS-CoV-2-IN-123 can be used for research related to coronavirus infection. | |||||||||||||||||||||
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