SARS-CoV-2-IN-123
SARS-CoV-2-IN-123 is a selective SARS-CoV-2 main protease (Mpro) inhibitor with an IC50 of 77 nM and a Kd of 38 nM. SARS-CoV-2-IN-123 exerts its inhibitory effect by blocking the polyprotein processing required for coronavirus replication, and its mechanism of action is independent of covalent cysteine modification or colloidal aggregation. SARS-CoV-2-IN-123 shows broad-spectrum antiviral activity in infected cells, along with favorable metabolic stability, plasma protein binding, and high Caco-2 permeability. SARS-CoV-2-IN-123 can be used for research related to coronavirus infection.
For research use only. We do not sell to patients.
- CAS No.: 2757286-41-0
- Formula: C21H16ClN3O2
- Molecular Weight:377.82
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
In Vitro
SARS-CoV-2-IN-123 (5-50 μM; association 60 s; dissociation 120 s) binds to SARS-CoV-2 Mpro by SPR with a KD of 0.038 μM[1].
SARS-CoV-2-IN-123 (0.019-20 μM; 72 h) inhibits SARS-CoV-2 CPE in Vero E6 cells with an EC50 of 0.077 μM and a CC50 > 20 μM[1].
SARS-CoV-2-IN-123 (72 h) inhibits SARS-CoV-2 viral replication in the Vero E6 yield reduction assay with an EC50 of 0.044 μM[1].
SARS-CoV-2-IN-123 (4 days) inhibits SARS-CoV-2 CPE in Huh7 cells with an EC50 of 0.11 μM[1].
SARS-CoV-2-IN-123 (4 days) inhibits SARS-CoV-1 CPE in Vero E6 cells with an EC50 of 0.39 μM[1].
SARS-CoV-2-IN-123 (2 μM; 42 h) inhibits MERS-CoV CPE in Huh7 cells with an EC50 of 0.20 μM[1].
SARS-CoV-2-IN-123 (10 μM; 15-60 min) exhibits high permeability in Caco-2 cells, with no efflux effect observed[1].
SARS-CoV-2-IN-123 (1 μM; 0-60 min) exhibits good metabolic stability in human liver microsomes, with a CLint of 22 μL/min/mg[1].
SARS-CoV-2-IN-123 (10 μM; 4 h) has fu = 3.3% in human plasma[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2757286-41-0
-
Molecular Weight 377.82
-
Formula C21H16ClN3O2
-
SMILES
O=C1NC2(CC(C2)C3=C(Cl)C=CC=C3)C(N1C4=CN=CC5=CC=CC=C54)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SARS-CoV-2-IN-123 Related Classifications
HY-187961 Related Classifications
Powered by Bioz