372146-20-8
Chemical Structure
Human β-defensin-2
Synonym(s): HβD-2
- CAS No.: 372146-20-8
- Formula:C188H305N55O50S6
- Molecular Weight:4328.20
SMILES: O=C(N[C@@H]([C@@H](C)CC)C(NCC(N[C@@H](CC(O)=O)C(N1[C@@H](CCC1)C(N[C@@H](C(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CSSC[C@@H]2NC3=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(NCC(N[C@@H](C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CSSC[C@@H](C(NCC(N[C@@H](CC(C)C)C(N4[C@@H](CCC4)C(NCC(N[C@@H]([C@H](O)C)C(N[C@H]3CCCCN)=O)=O)=O)=O)=O)=O)NC5=O)C(N[C@@H](CC6=CNC=N6)C(N7[C@@H](CCC7)C(N[C@@H](C(C)C)C(N[C@@H](CC8=CC=CC=C8)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N9[C@@H](CCC9)C(O)=O)=O)=O)=O)NC2=O)C(N%10[C@@H](CCC%10)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC%11=CC=C(C=C%11)O)C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@@H](C)CC)C(NCC(N[C@H]5[C@H](O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN
Biological Activity: Human β-defensin-2 (HβD-2) is an orally active, cysteine-rich antimicrobial peptide secreted by epithelial cells, with antibacterial, antiviral, and immunomodulatory activities. Human β-defensin-2 binds to CCR2, reduces NF-κB phosphorylation, increases CREB phosphorylation, inhibits pro-inflammatory cytokines, induces IL-10, and chemotaxes immune cells through CCR2/CCR6. Human β-defensin-2 reduces smoke-induced neutrophil influx in mouse lungs, downregulates pulmonary pro-inflammatory signaling, promotes bacterial clearance, and improves colitis and asthma cytokine/lung resistance. Human β-defensin-2 can be used in research related to diseases such as inflammatory bowel disease, bacterial infections, viral infections, and atopic asthma[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Human β-defensin-2 | 98.22% | Human β-defensin-2 (HβD-2) is an orally active, cysteine-rich antimicrobial peptide secreted by epithelial cells, with antibacterial, antiviral, and immunomodulatory activities. Human β-defensin-2 binds to CCR2, reduces NF-κB phosphorylation, increases CREB phosphorylation, inhibits pro-inflammatory cytokines, induces IL-10, and chemotaxes immune cells through CCR2/CCR6. Human β-defensin-2 reduces smoke-induced neutrophil influx in mouse lungs, downregulates pulmonary pro-inflammatory signaling, promotes bacterial clearance, and improves colitis and asthma cytokine/lung resistance. Human β-defensin-2 can be used in research related to diseases such as inflammatory bowel disease, bacterial infections, viral infections, and atopic asthma. | ||||||||||||||||||||
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References
- [1]. Koeninger L, et al. Human β-Defensin 2 Mediated Immune Modulation as Treatment for Experimental Colitis. Frontiers in immunology. 2020;11:93. [Content Brief]
- [2]. Kim J, et al. Human β-defensin 2 plays a regulatory role in innate antiviral immunity and is capable of potentiating the induction of antigen-specific immunity. Virology journal. 2018 Aug 08;15(1):124.
- [3]. Milad N, et al. Recombinant human β-defensin 2 delivery improves smoking-induced lung neutrophilia and bacterial exacerbation. American journal of physiology. Lung cellular and molecular physiology. 2022 Jul 01;323(1):L37-L47.
- [4]. Du Y, et al. A Human β-Defensin-Based Recombinant Protein DF2-HSA Ameliorates Cytokine Storm. Cells. 2026 Jan 21;15(2):202.
- [5]. Borchers NS, et al. Human β-Defensin 2 Mutations Are Associated With Asthma and Atopy in Children and Its Application Prevents Atopic Asthma in a Mouse Model. Frontiers in immunology. 2021;12:636061.
