90365-60-9
Chemical Structure
3-epi-18β-Glycyrrhetinic acid
- CAS No.: 90365-60-9
- Formula:C30H46O4
- Molecular Weight:470.69
IUPAC Name: (2S,4aS,6aS,6bR,8aR,10R,12aS,12bR,14bR)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid
InChIKey: MPDGHEJMBKOTSU-GBWCSKBLSA-N
SMILES: C[C@]12[C@@]([C@]3(C)[C@@](CC1)(C(C)(C)[C@H](O)CC3)[H])(C(=O)C=C4[C@@]2(C)CC[C@]5(C)[C@]4(C[C@](C(O)=O)(C)CC5)[H])[H]
Biological Activity: 3-epi-18β-Glycyrrhetinic acid is an inhibitor of 11β-HSD1 and 11β-HSD2, with an IC50 of 0.17 μM against 11β-HSD2. 3-epi-18β-Glycyrrhetinic acid acts as a weak substrate for sulfotransferase 2A1. It serves as a biomarker for the toxicity of licorice-related pseudoaldosteronism. 3-epi-18β-Glycyrrhetinic acid is applicable to studies related to pseudoaldosteronism[1][2][3][4].
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3-epi-18β-Glycyrrhetinic acid | 3-epi-18β-Glycyrrhetinic acid is an inhibitor of 11β-HSD1 and 11β-HSD2, with an IC50 of 0.17 μM against 11β-HSD2. 3-epi-18β-Glycyrrhetinic acid acts as a weak substrate for sulfotransferase 2A1. It serves as a biomarker for the toxicity of licorice-related pseudoaldosteronism. 3-epi-18β-Glycyrrhetinic acid is applicable to studies related to pseudoaldosteronism. | |||||||||||||||||||||
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3-Epiglycyrrhetinic acid-d2 | 95.15% | 3-Epiglycyrrhetinic acid-d2 (3α-Glycyrrhetic acid-d2) is the deuterium-labeled 3-Epiglycyrrhetinic acid. 3-Epiglycyrrhetinic acid is a derivative of glycyrrhetic acid. Glycyrrhetic acid and its derivative are considered to have anti-inflammatory, anti-ulcer, and antiviral activities. | ||||||||||||||||||||
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3-Epiglycyrrhetinic acid-d3 | 98.17% | 3-Epiglycyrrhetinic acid-d3 (3α-Glycyrrhetic acid-d3) is the deuterium-labeled 3-Epiglycyrrhetinic acid. 3-Epiglycyrrhetinic acid is a derivative of glycyrrhetic acid. Glycyrrhetic acid and its derivative are considered to have anti-inflammatory, anti-ulcer, and antiviral activities. | ||||||||||||||||||||
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References
- [1]. Beseda I, et al. Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases. Bioorganic & medicinal chemistry. 2010 Jan 01;18(1):433-54. [Content Brief]
- [2]. Sakoda R, et al. Stereoisomerism at the 3-position of glycyrrhetinic acid affects pseudoaldosteronism-related toxicokinetics. Drug metabolism and disposition: the biological fate of chemicals. 2025 Nov;53(11):100180. [Content Brief]
- [3]. Sakoda R, et al. 3--18-Glycyrrhetinic Acid or Its Glucuronide, the Metabolites of Glycyrrhizinic Acid with Individual Differences, Correlated with Diagnostic Marker for Licorice-Induced Pseudoaldosteronism in Humans. Drug metabolism and disposition: the biological fate of chemicals. 2024 Nov 15;52(12):1407-1416. [Content Brief]
- [4]. Yoshino T, et al. The Role of 3-epi-18β-Glycyrrhetinic Acid and Hepatic Function in Licorice-Induced Pseudohyperaldosteronism. Kidney Int Rep. 2026 Jan 9;11(3):103771. [Content Brief]
