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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
β-sheet structures
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "β-sheet structures" in MCE Product Catalog:
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Cat. No.: HY-P1889
CAS No.: 721885-31-0
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Bim BH3, Peptide IV is an Aβ42-binding peptide and the pro-apoptotic BH3 domain of the BIM protein. Bim BH3, Peptide IV binds Aβ42 with a Kd of 7.1 μM. Bim BH3, Peptide IV modulates Aβ42 structure, fibrillization pathways, aggregate morphology, and membrane interactions, inhibiting fibril formation while enhancing protofibril assembly. Bim BH3, Peptide IV promotes Aβ42 β-sheet formation and accelerates aggregation. Bim BH3, Peptide IV enhances Aβ42 membrane internalization and bilayer stiffening. Bim BH3, Peptide IV induces neuronal cell death by enhancing BH3-induced membrane interactions of Aβ42 prefibrillar species. Bim BH3, Peptide IV can be used for research on Alzheimer's disease .
Cat. No.: HY-P4882A
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(Pyr3)-Amyloid β-Protein (3-42) TFA is an N-terminally truncated pyroglutamylated β-amyloid peptide. (Pyr3)-Amyloid β-Protein (3-42) TFA forms stable β-sheet structures across different pH values, co-oligomerizes with Aβ1-42 to form cytotoxic oligomers, induces tau-dependent cytotoxicity and neuronal loss, inhibits hippocampal LTP, and exhibits stronger protease resistance. (Pyr3)-Amyloid β-Protein (3-42) TFA exists in the brain tissues of human Alzheimer's disease patients, correlates with the pathogenesis of Alzheimer's disease, and follows a unique, faster oligomerization pathway. (Pyr3)-Amyloid β-Protein (3-42) TFA can be used in Alzheimer's disease-related research .
Cat. No.: HY-N8671
CAS No.: 256520-90-8
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Cat. No.: HY-P4882
CAS No.: 183449-57-2
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Cat. No.: HY-P4370
CAS No.: 342790-23-2
Cat. No.: HY-P5515
CAS No.: 409085-40-1
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Cat. No.: HY-P5967
CAS No.: 189064-06-0
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Cat. No.: HY-149509
CAS No.: 1510825-03-2
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α-Synuclein inhibitor 9 (Compound 20C) is an α-Synuclein inhibitor. α-Synuclein inhibitor 9 binds to cavities in mature α-synuclein fibrils and reduces the β-sheet structure. α-Synuclein inhibitor 9 inhibits A53T α-Syn aggregation. α-Synuclein inhibitor 9 has neuroprotective effect, improves brain functional connection and relieves motor dysfunction.α-Synuclein inhibitor 9 can be used for Parkinson’s disease (PD) research. .
Cat. No.: HY-P5340
CAS No.: 339091-39-3
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Cat. No.: HY-P1889A
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Bim BH3, Peptide IV TFA is an Aβ42-binding peptide and the pro-apoptotic BH3 domain of the BIM protein. Bim BH3, Peptide IV TFA binds Aβ42 with a Kd of 7.1 μM. Bim BH3, Peptide IV TFA modulates Aβ42 structure, fibrillization pathways, aggregate morphology, and membrane interactions, inhibiting fibril formation while enhancing protofibril assembly. Bim BH3, Peptide IV TFA promotes Aβ42 β-sheet formation and accelerates aggregation. Bim BH3, Peptide IV TFA enhances Aβ42 membrane internalization and bilayer stiffening. Bim BH3, Peptide IV TFA induces neuronal cell death by enhancing BH3-induced membrane interactions of Aβ42 prefibrillar species. Bim BH3, Peptide IV TFA can be used for research on Alzheimer's disease .
Cat. No.: HY-161658
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N-Caffeoyldopamine (Compound 6i) is an amyloid-beta aggregation inhibitor. N-Caffeoyldopamine can inhibit Aβ aggregation to form nano-rod-like structures, thereby preventing β-sheet formation. N-Caffeoyldopamine can be used for Alzheimer's disease research .
Cat. No.: HY-D3430
Cat. No.: HY-167189
CAS No.: 682763-67-3
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BF-158 is a quinoline-based Tau Protein fluorescent imaging probe that produces specific staining by recognizing the β-sheet structure of paired helical filaments (PHF)/neurofibrillary tangles (NFT) in tau aggregates, with EC50 values of 399 nM and 659 nM for tau fibrils and Aβ1-42 fibrils, respectively. BF-158 preferentially labels NFTs, neuropil threads, and PHF-type neurites. BF-158 is useful for the study and imaging of tau pathology in Alzheimer's disease .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
