2 Results for "

ADAMTS-5-IN-3

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "ADAMTS-5-IN-3" in MCE Product Catalog:

Cat. No.: HY-145061
CAS No.: 2688733-96-0
Purity:  98.89%
Target:  

ADAMTS

ADAMTS-5-IN-3 (Example 37-2) is a potent inhibitor of ADAMTS-5 and ADAMTS-4 with IC50s of 8 and 12 nM, respectively. ADAMTS-5-IN-3 can be used for the research of diseases involving degradation of cartilage or disruption of cartilage homeostasis, in particular osteoarthrosis and/or rheumatoid arthritis .
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Cat. No.: HY-N22053
CAS No.: 81907-63-3
Synonyms: Ganoderic acid A methyl ester
Methyl ganoderate A (Ganoderic acid A methyl ester) is a triterpenoid derivative. Methyl ganoderate A can be isolated from the fruiting bodies of G. lucidum. Methyl ganoderate A selectively inhibits CLK2 with an IC50 of 0.69 μM. Methyl ganoderate A inhibits the expression of ADAMTS5, MMP3, and MMP13, and reduces the levels of the cytokines IL-6, TNF-α, and IL-1β. Methyl ganoderate A can be used in research on knee osteoarthritis, Alzheimer's disease, and neuroinflammation .
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