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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
AM1 calculations
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "AM1 calculations" in MCE Product Catalog:
5
5 Cited Publications
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MK-3207 (Hydrochloride) is a potent and orally bioavailable CGRP receptor antagonist with IC50 of 0.12 nM and Ki of 0.024 nM, and is highly selective versus human AM1, AM2, CTR, and AMY3.
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1 Cited Publications
Cat. No.: HY-P1455
CAS No.: 148498-78-6
Synonyms: Human adrenomedullin-(1-52)-NH2
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Cat. No.: HY-129148
CAS No.: 149507-55-1
Synonyms: GAAM1
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Cat. No.: HY-171012
CAS No.: 21829-22-1
Synonyms: NSC 335504
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Clonixeril (NSC 335504) is a non-nucleotide hSTING modulator. Clonixeril has weak agonist activity at micromolar concentrations and results in antagonism of the hSTING WT pathway at low femtomolar (10 -15 M) and in some cases even attomolar (10 -18 M) concentrations. Clonixeril reduces hSTING oligomerization at a concentration of 1 aM-1 pM [1].
Cat. No.: HY-147910
CAS No.: 2499489-76-6
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Carpro-AM1 is a dual-acting FAAH/substrate-selective COX inhibitor with an IC50 value of 94 nM for FAAH [1].
Cat. No.: HY-N11472
CAS No.: 41545-37-3
Synonyms: RhAMnocitrin-3-O-β-D-glucopyranoside
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Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Extract Leguminosae/Fabaceae Extract Plant Flavonoids Flavones
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Cat. No.: HY-D1752
CAS No.: 522592-13-8
Synonyms: D-22421
Cat. No.: HY-178150
CAS No.: 2803921-87-9
WEE1-IN-14 (Compound 14) is a selective WEE1 inhibitor (IC50: 0.5 nM in L-RB-FEP calculations, 1.0 nM in ADP-Glo kinase assay). Inhibition of Wee1 in cancer cells disrupts the G2-M checkpoint, removes the regulatory controls on the cell cycle, and leads to early onset of mitotic failure followed by apoptosis of tumor cells. Therefore, WEE1-IN-14 is a useful tool for studying cancer biology [1].
Cat. No.: HY-D3422
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AM1-44 is a fixable, cationic styryl fluorescent dye primarily used for labeling nerve terminals and synaptic vesicles. In its free state, AM1-44 exhibits extremely weak fluorescence; upon insertion into the cell membrane, its fluorescence increases, and after endocytosis into vesicles and release via exocytosis, its fluorescence decreases. Therefore, it can be used to study synaptic activity, synaptic vesicle cycling, neurotransmitter release, and synaptic plasticity (Ex/Em = 480/598-600 nm in membrane environment) [1] .
Cat. No.: HY-D1637
CAS No.: 172646-43-4
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5-Nitro BAPTA tetramethyl ester is a calcium chelator. 5-Nitro BAPTA tetramethyl ester involves in the two-photon probe synthesis, and is used for real-time imaging of intracellular calcium ions, calcium waves monitoring at a depth of 100-300 μm in liver tissues for 1100-4000 s. 5-Nitro BAPTA tetramethyl ester, together with fluorescent compound 2-Me-substituted TM, can be used to form a red fluorescent probe (CaTM-2 AM) .
Cat. No.: HY-187523
CAS No.: 3120945-90-3
Synonyms: para-MLL
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Methylolanthanin (para-MLL) is a natural small-molecule metallophore identified in the culture supernatant of Methylobacterium extorquens AM1. Methylolanthanin binds lanthanide metal ions such as La 3+, Nd 3+ and Lu 3+. It is applicable to studies related to lanthanide metabolism, bacterial metallophores, metal homeostasis and methylotrophic metabolism [1] .
Cat. No.: HY-10302R
CAS No.: 957116-20-0
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MK-3207 hydrochloride (Standard) is the analytical standard of MK-3207 hydrochloride (HY-10302). This product is intended for research and analytical applications. MK-3207 hydrochloride is a potent and orally bioavailable CGRP receptor antagonist with IC50 of 0.12 nM and Ki of 0.024 nM, and is highly selective versus human AM1, AM2, CTR, and AMY3.
Cat. No.: HY-N12964
CAS No.: 106941-27-9
Category:
Alkaloids Simaroubaceae Extract Plant Quinoline Alkaloids Ailanthus altissima (Mill.) Swingle Extract
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Cat. No.: HY-183142
CAS No.: 2252341-45-8
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CLR/RAMP3-receptor antagonist-1 is a selective antagonist of the CLR/RAMP3 receptor (CLR/RAMP3, AM2 receptor), with pIC50 values of 5.86, 9.21 and 9.07 against AM1 (CLR/RAMP2), AM2 (CLR/RAMP3) and CGRP (CLR/RAMP1) receptors, respectively. CLR/RAMP3-receptor antagonist-1 reduces the levels of pancreatic cancer progression markers, induces apoptosis in vitro, and prolongs survival in mouse models of pancreatic cancer. CLR/RAMP3-receptor antagonist-1 can be used in pancreatic cancer-related research [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
