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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
BV-2 microglia
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "BV-2 microglia" in MCE Product Catalog:
Cat. No.: HY-164049
CAS No.: 2490544-50-6
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TG8-260 is a second-generation EP2 antagonist developed to alleviate the pathology of central nervous system and peripheral diseases driven by inflammation. TG8-260 can reduce neuroinflammation and gliosis in the hippocampus of rats after pilocarpine-induced persistent epileptic status. Pharmacokinetic data of TG8-260 showed that its plasma half-life was 2.14 hours and its oral bioavailability was 77.3%. TG8-260 is also a potent inhibitor of CYP450 and shows antagonistic activity in inhibiting EP2 receptor-mediated inflammatory gene expression in BV2-hEP2 microglia, which is suitable for studying anti-inflammatory pathways in animal models of peripheral inflammatory diseases .
Cat. No.: HY-N8090
CAS No.: 1961358-02-0
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Cat. No.: HY-N10386
CAS No.: 755036-41-0
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Alkaloids Plant Caryophyllaceae Extract Pyridine Alkaloids Disease Research Fields Inflammation/Immunology Stellaria dichotoma var. lanceolata Bge. Extract Indole Alkaloids
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Cat. No.: HY-119465
CAS No.: 135357-96-9
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Cat. No.: HY-N9675
CAS No.: 408324-76-5
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Cat. No.: HY-155762
CAS No.: 2968412-77-1
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Anti-neuroinflammation agent 1 is a potent anti-neuroinflammation agent that regulates polarization BV2 microglia cells from M1 phenotype to M2 phenotype .
Cat. No.: HY-N7018
CAS No.: 400604-12-8
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Triterpenes Plant Terpenoids Polyporaceae Extract Disease Research Fields Inflammation/Immunology
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Cat. No.: HY-N0859B
CAS No.: 1614245-13-4
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Plant Lignans Schisandra chinensis (Turcz.) Baill. Extract Phenylpropanoids Schisandraceae Extract
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Plant Terpenoids Diterpenoids Siegesbeckia pubescens Makino Extract Compositae/Asteraceae Extract
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Cat. No.: HY-N10458
CAS No.: 3000508-28-8
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Cat. No.: HY-118361
CAS No.: 1150586-64-3
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CB86 is a small-molecule ligand of the translocator protein TSPO, binding to 18-kDa TSPO with high affinity (IC50 1.6 nM). CB86 competitively binds the TSPO protein on the mitochondrial outer membrane, inhibits LPS-induced M1 pro-inflammatory activation of BV‑2 microglia, and simultaneously inhibits 6‑OHDA-induced ROS generation, apoptosis, and necrosis in PC12 cells, exerting anti-inflammatory and neuroprotective effects. CB86 can be used in research related to Parkinson's disease and rheumatoid arthritis .
Cat. No.: HY-N13729
CAS No.: 2376309-57-6
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Alkaloids Plant Other Alkaloids Stephania japonica (Thunb.) Miers Extract Menispermaceae Extract
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Cat. No.: HY-N21660
CAS No.: 854629-43-9
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Cat. No.: HY-180889
CAS No.: 2257497-15-5
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PROTAC BRD3 degrader-1 (compound D072) is a potent and selective PROTAC BRD3 degrader. PROTAC BRD3 degrader-1 selectively degrades BRD3 in mice, leading to the downregulation of H3K18ac without affecting BRD2 or BRD4. PROTAC BRD3 degrader-1 reduces intraocular inflammation in the experimental autoimmune uveitis (EAU) mouse mode and inhibits proinflammatory microglia in both uveitis retina and LPS (HY-D1056) treated mouse microglia cell line BV2. PROTAC BRD3 degrader-1 can be used for uveitis research .
Cat. No.: HY-190499
Target:
Parasite NOD-like Receptor (NLR) Interleukin Related Caspase TNF Receptor Reactive Oxygen Species (ROS)
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Anti-inflammatory agent 128 is a 2-azido-3-O-benzyl-2-deoxy sp 2-iminosugar glycolipid with anti-inflammatory, antitumor, and antiparasitic activities. Anti-inflammatory agent 128 exhibits broad-spectrum antiproliferative activity against multiple human tumor cell lines. Anti-inflammatory agent 128 elevates mitochondrial ROS levels in Leishmania donovani promastigotes. Anti-inflammatory agent 128 inhibits the inflammatory response of Bv.2 microglia under LPS stimulation, suppresses NLRP3 inflammasome activation, downregulates the pro-inflammatory mediators Tnfa, Il1β, and Il6, and upregulates Hmox1. Anti-inflammatory agent 128 attenuates reactive gliosis in isolated retinal explants from diabetic rats and ameliorates inflammation-related phenotypes associated with diabetic retinopathy. Anti-inflammatory agent 128 can be used in research on tumors, leishmaniasis, and diabetic retinopathy .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
