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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
25 Results for "
Bi-functional drug
" in MedChemExpress (MCE) Product Catalog:
Products (25)
25 Results for "Bi-functional drug" in MCE Product Catalog:
Cat. No.: HY-157763
Target:
Research Areas:
Mal-PEG1-Val-Cit-PABC-diphosphate-BTK degrader-1 is a cleavable linker-payload conjugate and cereblon-binding BTK bifunctional degrader. Mal-PEG1-Val-Cit-PABC-diphosphate-BTK degrader-1 induces BTK degradation and exerts cytotoxic effects when delivered via CD79b monoclonal antibody. Mal-PEG1-Val-Cit-PABC-diphosphate-BTK degrader-1, when formulated as a CD79b antibody-drug conjugate, achieves sustained in vivo BTK degradation in tumor-bearing mice with reduced systemic payload exposure. Mal-PEG1-Val-Cit-PABC-diphosphate-BTK degrader-1 can be used for the research of activated b-cell-like diffuse large b-cell lymphoma (ADC linker: (HY-130944); PROTAC: (HY-163295)) .
Cat. No.: HY-100133A
Purity: 96.18%
Cat. No.: HY-W011118
CAS No.: 23911-26-4
Research Areas:
DTPA anhydride is a bifunctional chelator precursor, and its anhydride group can react with primary amino groups in peptides, proteins, or polymers to form stable amide bonds, covalently linking the DTPA chelating scaffold to target molecules. DTPA anhydride reacts with the free amino termini of minigastrin and DGlu1-minigastrin to form DTPA-peptide conjugates without side-chain protection, and the resulting DTPA-conjugates can also bind radionuclides to synthesize radionuclide-labeled drug conjugates (RDCs). RDCs possess the ability to specifically target biomolecules and can be applied in medical imaging .
Cat. No.: HY-155902C
CAS No.: 88504-24-9
Synonyms: Maleimide-PEG3400-Hydroxy
Cat. No.: HY-136991
CAS No.: 95676-71-4
Target:
Research Areas:
Basacv is a DNA-polyintercalating bifunctional compound with DNA-high affinity. Basacv is structurally analogous to the antibiotic anti-tumour drug Triostin A and act as a bis-intercalator .
Cat. No.: HY-W1048552
Cat. No.: HY-W1049129B
Cat. No.: HY-W1049129C
Cat. No.: HY-122939
CAS No.: 161876-61-5
Research Areas:
MAIPGG is a bifunctional chelator and an intermediate in the synthesis of radionuclide drug conjugates (RDCs). MAIPGG can be for the radiolabeling of a variety of monoclonal antibodies with 99mTc or 186Re, which then can be used for radioimmunodetection and radioimmunotherapy of cancer .
Cat. No.: HY-W1048574E
Synonyms: OHC-PEG20000-carboxyl
Cat. No.: HY-W1048574I
Synonyms: OHC-PEG3400-carboxyl
Cat. No.: HY-155902D
CAS No.: 88504-24-9
Synonyms: Maleimide-PEG10000-Hydroxy
Cat. No.: HY-W1049129D
Cat. No.: HY-W1048574A
Synonyms: OHC-PEG2000-carboxyl
Cat. No.: HY-W1048574C
Synonyms: OHC-PEG5000-carboxyl
Cat. No.: HY-W1048574D
Synonyms: OHC-PEG10000-carboxyl
Cat. No.: HY-W1048574H
Synonyms: OHC-PEG1000-carboxyl
Cat. No.: HY-W1048574J
Synonyms: OHC-PEG40000-carboxyl
Cat. No.: HY-L951
505 compounds
Macrocyclic scaffolds are increasingly valued in modern drug discovery for their exceptional activity against undruggable targets (proteases, kinases, PPIs). 2026 marks a key commercial breakthrough for oral macrocyclic peptides: enlicitide, the world’s first oral PCSK9 macrocyclic peptide, has received FDA approval. Macrocyclic candidates targeting KRAS and other classic undruggable targets have also entered clinical development, validating macrocyclization as an effective strategy to overcome druggability barriers.
Two core R&D directions lead current macrocyclic drug design: AI-driven de novo generation and structural optimization of small-molecule macrocycles, and macrocyclic peptides based on sequence design and conformational engineering. Macrocycle druggability hinges on embedded linkers, which determine cyclization efficiency, final conformation and drug-like properties. Bifunctional reaction orthogonality is the core linker selection criterion. Our linker library enables stepwise intramolecular cyclization with suppressed side reactions, accommodates varied ring sizes, and covers three key reaction systems: amide condensation, nucleophilic substitution and CuAAC click chemistry.
Built on classical macrocyclization systems, the library is processed through reaction classification, bifunctional orthogonality evaluation, novelty clustering and redundancy removal, with PROTAC long-chain and ADC cleavable linkers explicitly excluded. Featuring rigid, semi-rigid and flexible scaffolds, it is widely applicable to small-molecule macrocycle synthesis and linear peptide cyclization.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
