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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
CC-92480
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "CC-92480" in MCE Product Catalog:
3
Target:
Research Areas:
Mezigdomide (CC-92480), a cereblon E3 ubiquitin ligase modulating agent (CELMoD), acts as a molecular glue. Mezigdomide shows high affinity to cereblon, resulting in potent antimyeloma activity .
Cat. No.: HY-129395R
CAS No.: 2259648-80-9
Synonyms: CC-92480 (Standard)
Research Areas:
Mezigdomide (Standard) is the analytical standard of Mezigdomide (HY-129395). This product is intended for research and analytical applications. Mezigdomide (CC-92480), a cereblon E3 ubiquitin ligase modulating agent (CELMoD), acts as a molecular glue. Mezigdomide shows high affinity to cereblon, resulting in potent antimyeloma activity .
Cat. No.: HY-190182
CAS No.: 2771847-91-5
Synonyms: CC-92480 derivative-1
Target:
Research Areas:
Mezigdomide derivative-1 (CC-92480 derivative-1) is a chiral α-methylglutarimide analog of Mezigdomide (HY-129395) and belongs to the CELMoD (CRBN E3 ubiquitin ligase modulator) class. After the introduction of a methyl group to lock the chirality, Mezigdomide derivative-1 almost completely loses CRBN binding and Aiolos protein degradation activity, indicating that this chiral site does not tolerate methyl substitution. Mezigdomide derivative-1 can be used for structure-activity relationship studies .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
