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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
52 Results for "
Ceramidase
" in MedChemExpress (MCE) Product Catalog:
Products (52)
52 Results for "Ceramidase" in MCE Product Catalog:
8
Target:
Nucleoside Antimetabolite/Analog SARS-CoV Virus Protease FAAH Ceramidase Glutathione Peroxidase
Research Areas:
Carmofur (HCFU) is a rat recombinant acid ceramidase inhibitor with an IC50 of 29 nM. Carmofur is also a protease inhibitor of SARS-CoV-2 main protease (Mpro), fatty acid amide hydrolase (FAAH) and N-acylethanolamine acid amidase (NAAA). Carmofur has anti-cancer, anti-inflammatory and anti-virus activities, and can be used for the study of COVID-19 and acute lung injury (ALI) .
2
2 Cited Publications
Target:
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Acid Ceramidase-IN-1 is orally active and blood-brain barrier penetrant acid ceramidase (AC, ASAH-1) inhibitor (hAC IC50=0.166 μM). Acid Ceramidase-IN-1 reduces AC activity, accumulates ceramide species (Cer (d18:0/16:0), Cer (d18:1/16:0)), and decreases sphingosine levels. Acid Ceramidase-IN-1 can be used for the study of severe neurological lysosomal storage diseases (LSDs) such as Gaucher’s disease (GD) and Krabbe’s disease (KD) .
2
2 Cited Publications
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LCL521 is an acid ceramidase (ACDase) inhibitor. LCL521 also inhibits the lysosomal acid sphingomyelinase (ASMase) .
2
2 Cited Publications
Target:
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LCL521 dihydrochloride is an acid ceramidase (ACDase) inhibitor. LCL521 also inhibits the lysosomal acid sphingomyelinase (ASMase) .
1
1 Cited Publications
Target:
Research Areas:
Ceranib-2 is a potent and nonlipid ceramidase inhibitor that inhibits cellular ceramidase activity with an IC50 of 28 μM in SKOV3 cells. Ceranib-2 induces the accumulation of multiple ceramide species, decreases levels of sphingosine and sphingosine-1-phosphate (S1P), and induces cell apoptosis. Anticancer activity .
1
1 Cited Publications
Target:
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HPA-12 is a blood-brain barrier-permeable small-molecule inhibitor of ceramide transfer protein (CERT) with four stereoisomers (the (1R,3R)-stereoisomer exhibits the highest activity). HPA-12 blocks the transport of ceramide from the endoplasmic reticulum to the Golgi apparatus by binding to the START domain of CERT, leading to intracellular ceramide accumulation and inhibition of sphingomyelin (SM) synthesis. HPA-12 induces endoplasmic reticulum stress via the GRP78/ATF6/CHOP axis and activates mitochondrial autophagy, thereby inhibiting cell growth and inducing apoptosis. In in vivo experiments, HPA-12 significantly reduces the leukemia burden and splenomegaly in mouse models of acute myeloid leukemia (AML) and prolongs survival. HPA-12 is applicable for the research of lipid metabolism in acute myeloid leukemia and Alzheimer's disease .
1
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D-NMAPPD ((1R,2R)-B13) is an acid ceramidase inhibitor. D-NMAPPD regulates NMDA receptor properties by enhancing endogenous production of ceramides. D-NMAPPD has anticancer effecs .
1
1 Cited Publications
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SPT-IN-1 (compound 1) is an orally active and potent SPT (serine palmitoyl transferase) inhibitor, with an IC50 of 5.19 nM for hSPT1. SPT-IN-1 can be used for type 2 diabetes and dyslipidemia research .
1
Target:
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D-erythro-MAPP (D-e-MAPP) is a ceramidase inhibitor, with an IC50 of 1-5 μM in vitro .
1
1 Cited Publications
Cat. No.: HY-P76735
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ASAH2; BCDase; N-Acylsphingosine Amidohydrolase 2; LCDase; Neutral Ceramidase; NCDase; Non-Lysosomal Ceramidase; HNAC1; N-Acylsphingosine Amidohydrolase (Non-Lysosomal Ceramidase) 2; Neutral/Alkaline Ceramidase; Acylsphingosine Deacylase 2; Mitochondrial
Species:
Mouse
Source:
HEK293
Cat. No.: HY-170794
CAS No.: 2035010-37-6
Target:
Research Areas:
ALT-007 is an orally active serine palmitoyltransferase (SPT) inhibitor that selectively reduces the levels of toxic very-long-chain deoxysphingolipids to enhance protein homeostasis. ALT-007 restores aging-related loss of muscle mass in a mouse model of sarcopenia. ALT-007 enhances protein homeostasis in both mouse and C. elegans models of aging and disease. ALT-007 can be used for age-related neuromuscular diseases research .
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ARN19702 is a selective, orally active, reversible, and brain-penetrant N-acylethanolamine acid amidase (NAAA) inhibitor with an IC50 of 230 nM for human NAAA. ARN19702 has pain relief effects .
Cat. No.: HY-N6723
CAS No.: 116355-84-1
Category:
Infection Human Gut Microbiota Metabolites Antibiotics Microorganism Disease Research Antibacterial Endogenous metabolite Disease Research Fields Other Antibiotics
Target:
Target:
Research Areas:
Ceranib1 is a ceramidase inhibitor. Ceranib1 inhibits ceramidase activity toward an exogenous ceramide analog, induces the accumulation of multiple ceramide species, decreases levels of sphingosine and S1P. Ceranib1 inhibits the proliferation of ovarian cancer cells .
Target:
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ARN14974, a benzoxazolone carboxamide, is a potent and systemically active inhibitors of intracellular acid ceramidase (IC50=79 nM) .
Cat. No.: HY-48917
CAS No.: 15049-93-1
Synonyms: C10 Bisphosphonate
Target:
Research Areas:
ARC39 (C10 Bisphosphonate) is a selective acid sphingomyelinase (acid sphingomyelinase, ASM) inhibitor (IC50 = 20 nM) that binds the catalytic zinc center and blocks sphingomyelin hydrolysis. ARC39 shows higher selectivity for acid sphingomyelinase than for neutral sphingomyelinase and Ser/Thr protein phosphatases, while not affecting acid ceramidase, neutral ceramidase, sphingosine kinase 1, and sphingosine kinase 2. ARC39 reduces pulmonary edema, platelet- and ASM-promoted melanoma adhesion, and necroptosis-associated ceramide accumulation, and restores necroptotic viability. ARC39 can be used in research on platelet-activating factor (PAF)-induced pulmonary edema, melanoma, major depressive disorder, and colorectal cancer .
Synonyms: URB913
Target:
Research Areas:
ARN 077 is a potent and selective N-acylethanolamine acid amidase (NAAA) inhibitor with an IC50 of 7 nM for human NAAA . ARN 077 significantly increases palmitoyl ethanolamine (PEA) levels within the CNS and has broad antinociceptive activity in mice and rats .
Cat. No.: HY-W688565
CAS No.: 18944-28-0
Target:
Research Areas:
(2S)-2-Amino-1-hydroxyoctadecan-3-one is the product generated by the decarboxylative condensation of L-serine and palmitoyl-CoA catalyzed by serine palmitoyltransferase (SPT) .
Synonyms: ACT-519276; OGT2378
Target:
Research Areas:
Sinbaglustat (OGT2378) is a dual inhibitor of glucosylceramide synthase (GCS) and non-lysosomal glucosyl ceramidase (GBA2). Sinbaglustat is an orally available N-alkyl iminosugar that crosses the blood-brain barrier. Sinbaglustat can be used for the research of central neurodegenerative diseases associated with lysosomal dysfunctions .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
