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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
38 Results for "
Chromosomal aberrations
" in MedChemExpress (MCE) Product Catalog:
Products (38)
38 Results for "Chromosomal aberrations" in MCE Product Catalog:
10
10
10 Publications Verification
Synonyms: 1,10-Phenanthroline monohydrate
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1 Cited Publications
Cat. No.: HY-N6739
CAS No.: 26048-05-5
1
1 Cited Publications
Cat. No.: HY-W017113
CAS No.: 149-30-4
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Antipain dihydrochloride is a protease inhibitor isolated from Actinomycetes. Antipain dihydrochloride inhibits N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced transformation and increases chromosomal aberrations. Antipain dihydrochloride restricts uterine DNA synthesis and function in mice .
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Oxiran-2-ylmethanol (Glycidol) is an ester product. Oxiran-2-ylmethanol induces base pair point mutations in bacterial strains and structural chromosome aberrations in cultured cells. Oxiran-2-ylmethanol forms N-(2,3-dihydroxypropyl)valine hemoglobin adducts. Oxiran-2-ylmethanol acts as an animal carcinogen but does not significantly induce micronucleated immature erythrocytes in animal bone marrow. Oxiran-2-ylmethanol enables anionic polymerization to produce linear poly(glycidol). Oxiran-2-ylmethanol can be used for cancer-related research .
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Tetraconazole is a selective irreversible inhibitor of 14-α-sterol demethylase (CYP51) with antifungal activity. Tetraconazole competitively binds to the enzyme to block fungal ergosterol synthesis, resulting in cell membrane damage. The EC50 of tetraconazole against wheat pathogens is 0.382-0.802 mg/L, and the EC50 against onion root tip meristem cell growth is 6.7 mg/L, and (R)-(+)-Tetraconazole is 1.49-1.98 times more active than (S)-(-)-Tetraconazole. Tetraconazole can also induce oxidative stress and chromosomal aberrations in plant cells .
Cat. No.: HY-W178327
CAS No.: 4921-49-7
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8-Chloro caffeine binds to adenosine receptors (Ki = 30 µM). 8-Chloro caffeine potentiates UV-induced chromosomal aberrations in Cl-I Chinese hamster embryonic lung cells. 8-Chloro caffeine is a derivative of the methylxanthine alkaloid caffeine .
Cat. No.: HY-136489
CAS No.: 763111-49-5
KU-0058948 is a potent PARP1 inhibitor with an IC50 of 3.4 nM. KU-0058948 induces the accumulation of DNA double-strand breaks through inhibition of PARP1, triggering chromosomal aberrations, cell cycle arrest, and apoptosis in homologous recombination-deficient cells, while impeding the recruitment of the NuRD/PcG complex to affect chromatin remodeling. KU-0058948 can be used for research on cancers such as myeloid leukemia .
Cat. No.: HY-127039
CAS No.: 37691-11-5
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Antipain is a protease inhibitor isolated from Actinomycetes. Antipain inhibits N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced transformation and increases chromosomal aberrations. Antipain restricts uterine DNA synthesis and function in mice .
Cat. No.: HY-W049875
CAS No.: 1689-89-0
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Nitroxynil is a broad-spectrum veterinary anthelmintic and a substrate of ABCG2. Nitroxynil inhibits ATP production by uncoupling the oxidative phosphorylation process of mitochondria, thereby disrupting the parasite body covering, impairing its motility, and ultimately inducing parasite death. Nitroxynil induces chromosomal aberrations, sister chromatid exchanges and abnormal sperm morphology, and interferes with spermatogenesis. Nitroxynil is widely applicable to studies on fascioliasis, myiasis, Haemonchus spp. infections, and Oestrus ovis infections .
Cat. No.: HY-N6739S
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Levofloxacin N-oxide is an oxidation product and impurity of Levofloxacin (HY-B0330), and it is a non-mutagen. Under specific concentration conditions with the addition of S-9 mixture, Levofloxacin N-oxide increases structural chromosomal aberrations in hamster lung cells .
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Ypenyl is a cytostatic. Ypenyl hydrochloride, belonging to the alkylating agent class, exhibits clear genotoxicity and cell cycle disruption properties. Ypenyl induces chromosomal aberrations in broad bean root tip meristem cells and leads to a decrease in the mitotic index. Ypenyl may be used in cancer research .
Cat. No.: HY-136489A
CAS No.: 2108829-86-1
KU-0058948 hydrochloride is a potent PARP1 inhibitor with an IC50 of 3.4 nM. KU-0058948 hydrochloride induces the accumulation of DNA double-strand breaks through inhibition of PARP1, triggering chromosomal aberrations, cell cycle arrest, and apoptosis in homologous recombination-deficient cells, while impeding the recruitment of the NuRD/PcG complex to affect chromatin remodeling. KU-0058948 hydrochloride can be used for research on cancers such as myeloid leukemia .
Cat. No.: HY-N6739R
CAS No.: 26048-05-5
Cat. No.: HY-19437
CAS No.: 74550-97-3
Synonyms: AT-1727
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Bimolane (AT-1727), a human topoisomerase II inhibitor, can be used as an anti-neoplastic agent and for the research of psoriasis. Bimolane shows leukemogenic activity and induces multiple types of chromosomal aberrations in human lymphocytes .
Cat. No.: HY-N4014
CAS No.: 72715-02-7
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Plant Flourensia oolepis S.F.Blake Extract Terpenoids Sesquiterpenes Compositae/Asteraceae Extract
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
