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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
D1-NLS
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "D1-NLS" in MCE Product Catalog:
Cat. No.: HY-122979
CAS No.: 55528-07-9
Synonyms: (+)-AY-23,028; d-Butaclamol hydrochloride
Target:
Research Areas:
(+)-Butaclamol hydrochloride ((+)-AY-23,028; d-Butaclamol hydrochloride) is a dopamine receptor antagonist that blocks D2 and D1 receptors. (+)-Butaclamol hydrochloride antagonizes Dopamine (HY-B0451)-induced relaxation with a KB of 2 nM-0.17 µM and a Ki of 0.19-0.37 µM. (+)-Butaclamol hydrochloride inhibits adenylyl cyclase-coupled dopamine receptors, displaces striatal D2 radioligand binding, and acts as a non-selective D2 antagonist to retain D1-NLS and D1-D2 hetero-oligomers on the cell surface. (+)-Butaclamol hydrochloride inhibits the rewarding effects and self-administration behavior of dopaminergic agonists. (+)-Butaclamol hydrochloride can be used in research related to schizophrenia [1] .
Cat. No.: HY-122979A
CAS No.: 56245-67-1
Synonyms: (+)-AY-23,028 free base; d-Butaclamol
Target:
Research Areas:
(+)-Butaclamol ((+)-AY-23,028 free base; d-Butaclamol) is a dopamine receptor antagonist that blocks D2 and D1 receptors. (+)-Butaclamol antagonizes Dopamine (HY-B0451)-induced relaxation with a KB of 2 nM-0.17 µM and a Ki of 0.19-0.37 µM. (+)-Butaclamol inhibits adenylyl cyclase-coupled dopamine receptors, displaces striatal D2 radioligand binding, and acts as a non-selective D2 antagonist to retain D1-NLS and D1-D2 hetero-oligomers on the cell surface. (+)-Butaclamol inhibits the rewarding effects and self-administration behavior of dopaminergic agonists. (+)-Butaclamol can be used in research related to schizophrenia [1] .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
