21 Results for "

DLD1

" in MedChemExpress (MCE) Product Catalog:
Products (21)

21 Results for "DLD1" in MCE Product Catalog:

5
BAY-8002
BAY-8002
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5 Cited Publications
Cat. No.: HY-122312
CAS No.: 724440-27-1
Purity:  98.39%
Target:  

Monocarboxylate Transporter

Research Areas:  

Cancer

BAY-8002 is a potent, selective, orally active inhibitor of monocarboxylate transporter 1 (MCT1), with an IC50 of 85 nM in the MCT1-expressing DLD-1 cells, displays excellent selectivity against MCT4. Anti-tumor activity [1].
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1
Epiblastin A
Epiblastin A
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1 Cited Publications
Cat. No.: HY-114858
CAS No.: 16470-02-3
Purity:  99.51%
Target:  

Casein Kinase Ser/Thr Kinase EGFR RIP kinase

Research Areas:  

Cancer

Epiblastin A is an ATP-competitive casein kinase 1 (CK1) inhibitor that inhibits CK1α, CK1δ, and CK1ε. Epiblastin A inhibits the kinase activity of STK10, BRSK1, EEF2K, EGFR, MKNK2, and RIPK2. Epiblastin A inhibits Ki-67 expression, induces Oct4-GFP expression, and enhances the conversion of mouse epiblast stem cells to embryonic stem cells. Epiblastin A selectively reduces the cell viability of colorectal cancer cell lines HCT116, HT29, and DLD1. Epiblastin A can be used in colorectal cancer-related research [1] .
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ABT-100
ABT-100
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1 Cited Publications
Cat. No.: HY-119257
CAS No.: 450839-40-4
Purity:  98.18%
Target:  

Farnesyl Transferase Apoptosis

Research Areas:  

Cancer

ABT-100, a chemical probe, is a potent, highly selective and orally active farnesyltransferase inhibitor. ABT-100 inhibits cell proliferation (IC50s of 2.2 nM, 3.8 nM, 5.9 nM, 6.9 nM, 9.2 nM, 70 nM and 818 nM for EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells, respectively), increases apoptosis and decreases angiogenesis. ABT-100 possesses broad-spectrum antitumor activity [1].
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MSC778
MSC778
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Cat. No.: HY-177512
CAS No.: 3098173-17-9
Target:  

FLAP

Research Areas:  

Cancer

MSC778 is an effective and orally active flap endonuclease 1 (FEN1) inhibitor with an IC50 of 3 nM and a KD of 2.9 nM. MSC778 exhibits 145-fold, 516-fold, and 65-fold selectivity over EXO1, GEN1, and XPG, respectively. MSC778 selectively kills BRCA2-deficient cells and potentiates the activity of Niraparib (HY-10619) to induce tumor stasis in a BRCA2 KO DLD-1 mouse xenograft. MSC778 can be used in the research of colorectal cancer [1].
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SR15006
SR15006
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Cat. No.: HY-139691
CAS No.: 2505001-54-5
Purity:  99.95%
Target:  

KLF

Research Areas:  

Cancer

SR15006 is a inhibitor of Krüppel-like factor 5 (KLF5) with an IC50 of 41.6 nM in DLD-1/pGL4.18hKLF5p cells) [1].
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PROTAC SOS1 degrader-4
PROTAC SOS1 degrader-4
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Cat. No.: HY-153674
Target:  

PROTACs SOS1

Research Areas:  

Cancer

PROTAC SOS1 degrader-4 (Compound 10) is a PROTAC degrader that targets the SOS1 protein for degradation by recruiting cereblon. It degrades SOS1 in NCI-H358, A-427, SW-620, and DLD-1 cells and inhibits the proliferation of various KRAS-mutant tumor cells, making it a useful tool for cancer research [1].
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DS-5272
DS-5272
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Cat. No.: HY-120667
CAS No.: 1235575-97-9
Target:  

MDM-2/p53 Apoptosis

Research Areas:  

Cancer

DS-5272 is an orally acitve inhibitor for p53-MDM2 with an IC50 of 20 nM. DS-5272 inhibits the proliferation of SJSA-1 (wildtype p53, IC50=0.17 μM) and DLD-1 (mutant p53). DS-5272 arrest the cell cycle, and induces apoptosis in SJSA-1. DS-5272 exhibits antitumor efficacy in mice [1].
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SB-T-1214
SB-T-1214
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Cat. No.: HY-165606
CAS No.: 178250-23-2
Target:  

Oct3/4 c-Myc Apoptosis

Research Areas:  

Cancer

SB-T-1214 (SBT) is a taxane. SB-T-1214 efficiently inhibits expression of stem cell-related genes (Oct4, Sox2, and c-Myc) and induces apoptosis of colon cancer spheroids with drug resistant tumorigenic CD133 +/CD44 + cells. SB-T-1214 strongly represses tumor growth in Pgp+ DLD-1 human colon tumor xenografts mice model. SB-T-1214 can be used for antitumor research, especially against tumors with drug resistance, such as colon, pancreatic and renal cancers [1] .
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PROTAC SOS1 degrader-10
PROTAC SOS1 degrader-10
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Cat. No.: HY-161654
CAS No.: 3043923-74-3
Target:  

PROTACs SOS1 Ras PERK

Research Areas:  

Cancer

PROTAC SOS1 degrader-10 is a SOS1 PROTAC degrader dependent on CRBN and the proteasome. PROTAC SOS1 degrader-10 degrades SOS1 in KRAS-mutant cancer cells SW620, A549 and DLD-1, with DC50 values of 2.23, 1.85 and 7.53 nM, respectively. PROTAC SOS1 degrader-10 inhibits ERK phosphorylation. PROTAC SOS1 degrader-10 suppresses the proliferation of KRAS-mutant cancer cells via antiproliferative activity. PROTAC SOS1 degrader-10 can be used in studies related to KRAS-mutant cancers [1].
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PRMT5-MTA-IN-4
PRMT5-MTA-IN-4
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Cat. No.: HY-176701
CAS No.: 3025838-18-7
Target:  

Histone Methyltransferase

Research Areas:  

Cancer

PRMT5-MTA-IN-4 (Compound 30) is a potent irreversible protein arginine methyltransferase 5 (PRMT5) inhibitor (IC50=8 nM). PRMT5-MTA-IN-4 blocks arginine methylation, inhibiting ribosomal RNA processing and cell cycle-related protein expression. PRMT5-MTA-IN-4 exhibits antiproliferative activity in multiple tumor cell lines (e.g., IC50=0.3 μM in DLD-1 cells). PRMT5-MTA-IN-4 is promising for research of hematological malignancies, such as acute myeloid leukemia, diffuse large B-cell lymphoma [1].
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LDHA-IN-9
LDHA-IN-9
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Cat. No.: HY-168733
CAS No.: 862719-04-8
Target:  

Lactate Dehydrogenase Apoptosis

Research Areas:  

Cancer

LDHA-IN-9 (Compound 1g) is an inhibitor for LDH-A with an IC50 of 25 nM. LDHA-IN-9 inhibits the proliferation of DLD-1 cell (GI50 of 27 μM) through apoptosis induction. LDHA-IN-9 exhibits antitumor activity in mouse model without significant toxicity (25 mg/kg) [1].
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Jacaric acid
Jacaric acid
0 Images
Cat. No.: HY-121619
CAS No.: 28872-28-8
Category:  

Ketones, Aldehydes, Acids Plants Caprifoliaceae Extract 500 - Internal Server Error | MedChemExpress

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