191

191 Publications Verification

Synonyms: 4',6-Diamidino-2-phenylindole dihydrochloride

DAPI (4',6-Diamidino-2-phenylindole) dihydrochloride is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. DAPI cannot penetrate intact cell membranes and is commonly used for staining damaged and fixed cells . DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment (Ex/Em = 356/451 nm).

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191

DAPI

191 Publications Verification

Cat. No.: HY-D2868

CAS No.: 47165-04-8

Synonyms: 4',6-Diamidino-2-phenylindole

DAPI (4',6-Diamidino-2-phenylindole) is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. DAPI cannot penetrate intact cell membranes and is commonly used for staining damaged and fixed cells . DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment (Ex/Em = 356/451 nm).

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185

DAPI dilactate

185 Cited Publications

Cat. No.: HY-D1738

CAS No.: 28718-91-4

Synonyms: 4',6-Diamidino-2-phenylindole dilactate

DAPI (4',6-Diamidino-2-phenylindole) dilactate is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. DAPI cannot penetrate intact cell membranes and is commonly used for staining damaged and fixed cells . DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment (Ex/Em = 356/451 nm) .

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122

PX-478

122 Cited Publications

Cat. No.: HY-10231

CAS No.: 685898-44-6

Purity: ≥98.0%

Target:

HIF/HIF Prolyl-Hydroxylase VEGFR Autophagy

Research Areas:

Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer

PX-478 is a multifunctional HIF-1α inhibitor with properties including radiosensitization, autophagy activation, and lipid accumulation inhibition. PX-478 also blocks hypoxia-induced VEGF production and regulates β-cell phenotypes under hypoxic conditions. PX-478 induces cell cycle arrest and DNA damage, restores autophagic function, reduces foam cell formation, and maintains glucose homeostasis. PX-478 is widely used in research on related diseases such as human tumors (e.g., prostate cancer), type 2 diabetes, and atherosclerosis .

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53

NAD+ lithium

53 Cited Publications

Cat. No.: HY-W250163

CAS No.: 64417-72-7

Synonyms: β-DPN lithium; β-NAD lithium; β-Nicotinamide Adenine Dinucleotide lithium

NAD+ lithium (β-DPN lithium) is a lithium salt of nicotinamide adenine dinucleotide. NAD+ is a coenzyme in the REDOX reaction. NAD+ can directly or indirectly affect several key cellular functions, including metabolic pathways, DNA repair, chromatin remodeling, cell aging, and immune cell function .

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31

cGAMP

31 Cited Publications

Cat. No.: HY-12512

CAS No.: 849214-04-6

Purity: 98.28%

Synonyms: Cyclic GMP-AMP; 3',3'-cGAMP

Target:

STING

Research Areas:

Inflammation/Immunology

cGAMP (Cyclic GMP-AMP) functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators .

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31

cGAMP disodium

31 Cited Publications

Cat. No.: HY-110385

CAS No.: 2407516-83-8

Purity: 98.47%

Synonyms: Cyclic GMP-AMP disodium; 3',3'-cGAMP disodium

Category:

Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

STING Endogenous Metabolite

cGAMP (Cyclic GMP-AMP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators .

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31

cGAMP diammonium

31 Cited Publications

Cat. No.: HY-110385A

Purity: 95.19%

Synonyms: Cyclic GMP-AMP diammonium; 3',3'-cGAMP diammonium

Category:

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

STING Endogenous Metabolite

cGAMP (Cyclic GMP-AMP) diammonium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators .

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22

L-Leucyl-L-Leucine methyl ester hydrochloride

22 Cited Publications

Cat. No.: HY-129905

CAS No.: 6491-83-4

Purity: 98.92%

Synonyms: LLOMe hydrochloride; Leu-Leu methyl ester hydrochloride; H-Leu-Leu-OMe hydrochloride

Category:

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Apoptosis Caspase

L-Leucyl-L-Leucine methyl ester (LLOMe; Leu-Leu methyl ester; H-Leu-Leu-OMe) hydrochloride is a lysosomal disrupting agent and apoptosis inducer that, through receptor-mediated endocytosis and lysosomal dipeptidyl peptidase I conversion, induces caspase activation, lysosomal membrane permeabilization, and DNA fragmentation, and requires cathepsin C to exert membrane-lytic activity, thereby selectively killing natural killer cells. L-Leucyl-L-Leucine methyl ester hydrochloride can be used for research related to lysosomal function and apoptosis .

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22

L-Leucyl-L-Leucine methyl ester hydrobromide

22 Cited Publications

Cat. No.: HY-129905A

CAS No.: 16689-14-8

Purity: 99.69%

Synonyms: LLOMe hydrobromide; Leu-Leu methyl ester hydrobromide; H-Leu-Leu-OMe hydrobromide

Category:

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Apoptosis Caspase

L-Leucyl-L-Leucine methyl ester (LLOMe; Leu-Leu methyl ester; H-Leu-Leu-OMe) hydrobromide is a lysosomal disrupting agent and apoptosis inducer that, through receptor-mediated endocytosis and lysosomal dipeptidyl peptidase I conversion, induces caspase activation, lysosomal membrane permeabilization, and DNA fragmentation, and requires cathepsin C to exert membrane-lytic activity, thereby selectively killing natural killer cells. L-Leucyl-L-Leucine methyl ester hydrobromide can be used for research related to lysosomal function and apoptosis .

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21

DOTAP methylsulfate

21 Cited Publications

Cat. No.: HY-W127378

CAS No.: 144189-73-1

Synonyms: 1,2-Dioleoyl-3-trimethylammonium-propane methylsulfate

Target:

Liposome

Research Areas:

Others

DOTAP methylsulfat is a cationic lipid reagent, a cationic derivative of trimethylammonium, linked to two 18-carbon fatty acid tails, each with a single olefin group. DOTAP methylsulfat can self-assemble with negatively charged ions (such as DNA) to form complexes, which can be adsorbed to the cell membrane surface and enter the cell by electrostatic interaction and endocytosis, respectively. DOTAP methylsulfat promotes endosomal membrane fusion with its own hydrophobic domain, releases DNA into the cytoplasm, and exerts gene delivery function. DOTAP methylsulfat can be widely used in research fields such as gene therapy, cell transfection, and non-viral vector design .

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14

Novobiocin

14 Cited Publications

Cat. No.: HY-B0425

CAS No.: 303-81-1

Synonyms: Albamycin; Cathomycin

Target:

Antibiotic DNA/RNA Synthesis HSP Apoptosis Bacterial Parasite

Novobiocin (Albamycin; Cathomycin) is an orally active antibiotic and Hsp-90 antagonist that also inhibits the Polθ helicase/ATPase domain with IC₅₀ values of 24 μM and 15-17 μM, respectively. Novobiocin binds to Hsp90, GyrB, and POLθ, inhibiting their ATPase activity and ssDNA binding. Novobiocin inhibits molecular chaperone function and DNA repair, and induces apoptosis and genomic instability. Novobiocin exhibits bactericidal and antiparasitic activities. Novobiocin inhibits tumor growth in vivo. Novobiocin is used for research on equine piroplasmosis, ovarian cancer, breast cancer, anthrax, and melioidosis .

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14

Novobiocin sodium

14 Cited Publications

Cat. No.: HY-B0425A

CAS No.: 1476-53-5

Synonyms: Albamycin sodium; Cathomycin sodium

Category:

Microorganisms Anti-inflammation/Immunoregulatory Antibiotics Antiviral Disease Research Antibacterial Disease Research Fields Other Antibiotics Cancer

Target:

Antibiotic DNA/RNA Synthesis HSP Apoptosis Bacterial Parasite

Novobiocin (Albamycin; Cathomycin) sodium is an orally active antibiotic and Hsp-90 antagonist that also inhibits the Polθ helicase/ATPase domain with IC₅₀ values of 24 μM and 15-17 μM, respectively. Novobiocin sodium binds to Hsp90, GyrB, and POLθ, inhibiting their ATPase activity and ssDNA binding. Novobiocin sodium inhibits molecular chaperone function and DNA repair, and induces apoptosis and genomic instability. Novobiocin sodium exhibits bactericidal and antiparasitic activities. Novobiocin sodium inhibits tumor growth in vivo. Novobiocin sodium is used for research on equine piroplasmosis, ovarian cancer, breast cancer, anthrax, and melioidosis .

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11

Cladribine

11 Cited Publications

Cat. No.: HY-13599

CAS No.: 4291-63-8

Purity: 99.97%

Synonyms: 2-Chloro-2′-deoxyadenosine; CldAdo; 2CdA

Target:

Adenosine Deaminase Apoptosis

Research Areas:

Cardiovascular Disease Cancer

Cladribine (2-Chloro-2′-deoxyadenosine), a purine nucleoside analog, is an orally active adenosine deaminase inhibitor. Cladribine functions as an inhibitor of DNA synthesis to block the repair of the damaged DNA. Cladribine can inhibit DNA methylation. Cladribine has anti-lymphoma activity. Cladribine can be used for the research of several hematologic malignancies and multiple sclerosis .

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