5

Ibutamoren Mesylate

5 Cited Publications

Cat. No.: HY-50844

CAS No.: 159752-10-0

Synonyms: MK-677; MK-0677

Target:

GHSR

Research Areas:

Endocrinology

Ibutamoren Mesylate (MK-677) is a potent, non-peptide Growth hormone secretagogue receptor (GHSR) agonist. Ibutamoren Mesylate is an orally active growth hormone (GH) secretagogue.

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3

JMV 2959

3 Cited Publications

Cat. No.: HY-U00433

CAS No.: 925238-89-7

Target:

GHSR

Research Areas:

Neurological Disease Endocrinology

JMV 2959 is a growth hormone secretagogue receptor type 1a (GHS-R_1a) antagonist with an IC₅₀ of 32 nM.

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3

JMV 2959 hydrochloride

3 Cited Publications

Cat. No.: HY-U00433A

CAS No.: 2448414-54-6

Target:

GHSR

Research Areas:

Neurological Disease Endocrinology

JMV 2959 hydrochloride is a growth hormone secretagogue receptor type 1a (GHS-R_1a) antagonist with an IC₅₀ of 32±3 nM in LLC-PK₁ cells.

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2

Relamorelin TFA

2 Cited Publications

Cat. No.: HY-19884B

CAS No.: 2863659-22-5

Synonyms: RM-131 TFA; BIM-28131 TFA

Target:

GHSR

Research Areas:

Metabolic Disease

Relamorelin (RM-131) TFA, a pentapeptide ghrelin analog, is a selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist with a K_i of 0.42 nM for GHS-1a receptor. Relamorelin TFA is centrally penetrant. Relamorelin TFA increases growth hormone levels and accelerates gastric emptying. Relamorelin TFA has the potential for cachexia, gastroparesis, and gastric/intestinal dysmobility disorders research .

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1

LEAP-2

1 Cited Publications

Cat. No.: HY-P5645

CAS No.: 1683582-94-6

Synonyms: Human liver expressed antimicrobial peptide-2

Target:

GHSR Interleukin Related IFNAR TNF Receptor Bacterial

Research Areas:

Infection Metabolic Disease Inflammation/Immunology

LEAP-2 (Human liver expressed antimicrobial peptide-2) is a GHS-R1a antagonist, with an IC₅₀ of 6.0 nM. LEAP-2 suppresses the orexigenic effect of ghrelin. LEAP-2 attenuates ghrelin-induced growth hormone (GH) release and reduces basal food intake. LEAP-2 exhibits antimicrobial activity against microbial model organisms. LEAP-2 can be used for the study of obesity and infection .

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1

des-Gln14-Ghrelin

1 Cited Publications

Cat. No.: HY-P1366

CAS No.: 293735-04-3

Target:

GHSR

Research Areas:

Metabolic Disease

des-Gln14-Ghrelin is a second endogenous ligand for the growth hormone secretagogue receptor. a). des-Gln14-ghrelin potently induces increases in [Ca ²⁺]i in CHO-GHSR62 cells, with an EC₅₀ of 2.4 nM .

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