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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
Glue02
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "Glue02" in MCE Product Catalog:
Cat. No.: HY-190178
CAS No.: 2034581-68-3
Target:
Research Areas:
Glue02 is a CCNK molecular glue degrader with a DC50 < 0.1 μM. Glue02 binds to the kinase domain of CDK12, promotes the formation of a ternary complex between CDK12 and the DDB1-CUL4-RBX1 E3 ubiquitin ligase complex, converts CDK12 into a substrate-specific receptor, and induces polyubiquitination and proteasomal degradation of CCNK. Glue02 inhibits cancer cell proliferation. Glue02 can be used in cancer-related research .
Cat. No.: HY-190177
CAS No.: 2750644-44-9
Target:
Research Areas:
Glue02-35 is a CCNK molecular glue degrader with a DC50 < 0.1 μM. Glue02-35 binds to the kinase domain of CDK12, promotes the formation of a ternary complex between CDK12 and the DDB1-CUL4-RBX1 E3 ubiquitin ligase complex, and converts CDK12 into a substrate-specific receptor, inducing polyubiquitination and proteasomal degradation of CCNK. Glue02-35 inhibits cancer cell proliferation. Glue02-35 can be used for cancer-related research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
