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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
49 Results for "
Gradient RP-HPLC
" in MedChemExpress (MCE) Product Catalog:
Products (49)
49 Results for "Gradient RP-HPLC" in MCE Product Catalog:
10
Category:
Infection Microorganisms Antibiotics Disease Research Anticancer Disease Research Fields Other Antibiotics
Target:
4
3
Research Areas:
9-Amino-6-chloro-2-methoxyacridine (ACMA) is an acridine derivative and Fluorescent probe. 9-Amino-6-chloro-2-methoxyacridine inhibits viral replication, inhibits DNA synthesis and protein metabolism through cell cycle arrest, and induces lipid metabolism regulation, genotoxicity, mutagenicity, and cytotoxicity through DNA strand breaks. 9-Amino-6-chloro-2-methoxyacridine partially intercalates into DNA, forming three distinct complexes, stabilizes the DNA helix, and quenches fluorescence upon intercalation through electron transfer with guanine. 9-Amino-6-chloro-2-methoxyacridine monitors the generation and collapse of the proton motive force, H + pumping by F1F0-ATP synthase, and the collapse of pH gradients in inverted membrane vesicles. 9-Amino-6-chloro-2-methoxyacridine shows potent anti-BVDV activity. 9-Amino-6-chloro-2-methoxyacridine can be used for research on bovine viral diarrhea virus infection, leishmaniasis, and MRSA infection .
1
Sodium bicarbonate (Sodium hydrogen carbonate; Soda bicarbonate) is an inorganic salt that is neutral to slightly alkaline and easily decomposes when exposed to moisture in the air. Sodium bicarbonate can maintain the pH of the culture medium, thereby affecting the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in macrophages and reversing the acidosis of the tumor microenvironment. Sodium bicarbonate is widely used in the fields of food, medicine, cosmetics, etc. Its main uses include buffers, flavoring agents, disinfectants, pharmaceuticals, and proton gradient regulators. Sodium bicarbonate is also commonly used as an antacid to inhibit gastrointestinal diseases, neutralize gastric acid, and reduce gastric discomfort .
1
1 Cited Publications
Cat. No.: HY-P5831
Target:
Research Areas:
1
1
1 Cited Publications
Cat. No.: HY-P7466
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: AGR3; Anterior Gradient Protein 3; Anterior Gradient 3, Protein Disulphide Isomerase Family Member; AG-3; BCMP11; AG3; PDIA18; Anterior Gradient 3 Homolog (Xenopus Laevis); HAG-3; Anterior Gradient Protein 3 Homolog; Protein Disulfide Isomerase Family A,
Species:
Human
Source:
HEK293
Cat. No.: HY-W251598C
CAS No.: 144-55-8
Synonyms: Sodium hydrogen carbonate for cell culture; Soda bicarbonate for cell culture
Cat. No.: HY-W251598B
CAS No.: 144-55-8
Synonyms: Sodium hydrogen carbonate for molecular biology; Soda bicarbonate for molecular biology
Cat. No.: HY-P3003
CAS No.: 157232-64-9
Category:
Cat. No.: HY-W014180
CAS No.: 39145-52-3
Category:
Animals Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields
Target:
Cat. No.: HY-W251598S
CAS No.: 87081-58-1
Research Areas:
3-t-Butylphenol is a mitochondrial uncoupler. 3-t-Butylphenol disrupts the proton gradient, inhibits ATP synthesis and induces cytotoxicity .
Synonyms: Indanyl carbenicillin sodium; CP-15464-2
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Research Areas:
Carindacillin sodium (Indanyl carbenicillin sodium; CP-15464-2) is an orally active prodrug of Carbenicillin (HY-B0525). Carindacillin sodium undergoes intestinal uptake via a proton gradient-driven carrier-mediated pathway and is rapidly hydrolyzed in vivo to release the bioactive Carbenicillin, which interferes with cell wall synthesis by inhibiting bacterial penicillin-binding proteins. Carindacillin sodium can be used in research related to bacterial infections .
Cat. No.: HY-P3003S
CAS No.: 1487375-69-8
Cat. No.: HY-W035904
CAS No.: 539-80-0
Synonyms: Cycloheptatrienone
Category:
Ketones, Aldehydes, Acids Other Diseases Plants Other Families Extract Disease Research Fields
Target:
Cat. No.: HY-W251598I
CAS No.: 144-55-8
Synonyms: Sodium hydrogen carbonate, meets analytical specification of Ph. Eur., BP, USP, FCC, E500
MA220607 is a FtsZ protein inhibitor with activity against both Gram-positive and Gram-negative bacteria. MA220607 inhibits bacterial growth and shows low bacterial resistance frequency. MA220607 increases bacterial membrane permeability and alters proton gradients. MA220607 blocks the formation of bacterial biofilms. MA220607 can be used in studies of bacterial infections .
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Research Areas:
PB1 is a potent intracellular disulfide reducing agent with several advantages including good cell permeability, the ability to form a high intracellular concentration gradient, and stability. PB1 is a borane-protected TCEP (tris(2-carboxyethyl)phosphine) analogue. PB1 increases retinal ganglion cells survival after axotomy in vitro at nanomolar and picomolar concentrations. PB1 can be used for the research of neuroprotective .
Gradient elution with sodium acetate buffer-ACN eluent on two ZIC-HILIC homemade columns separates 2-deoxyuridine in under 9 min .
In Vivo:2'-Deoxyuridine (34.42 ng/mL, gavage, 15 min) passes the blood-brain barrier (BBB) to enter the hippocampus of mice brain . 2'-Deoxyuridine (20 mg/kg, gavage, daily for 4 weeks) improves cognition and memory loss and attenuates the damage to the hippocampus in Aβ25-35-induced mice model .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
