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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
H1-1
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "H1-1" in MCE Product Catalog:
3
Target:
Research Areas:
(R)-CR8, a second-generation analog of Roscovitine, is a potent CDK1/2/5/7/9 inhibitor. (R)-CR8 inhibits CDK1/cyclin B (IC50=0.09 μM), CDK2/cyclin A (0.072 μM), CDK2/cyclin E (0.041 μM), CDK5/p25 (0.11 μM), CDK7/cyclin H (1.1 μM), CDK9/cyclin T (0.18 μM) and CK1δ/ε (0.4 μM). (R)-CR8 induces apoptosis and has neuroprotective effect . (R)-CR8 acts as a molecular glue degrader that depletes cyclin K .
3
3 Cited Publications
Cat. No.: HY-18340A
CAS No.: 1786438-30-9
Synonyms: CR8, (R)-Isomer trihydrochloride
Target:
Research Areas:
(R)-CR8 (CR8) trihydrochloride, a second-generation analog of Roscovitine, is a potent CDK1/2/5/7/9 inhibitor. (R)-CR8 trihydrochloride inhibits CDK1/cyclin B (IC50=0.09 μM), CDK2/cyclin A (0.072 μM), CDK2/cyclin E (0.041 μM), CDK5/p25 (0.11 μM), CDK7/cyclin H (1.1 μM), CDK9/cyclin T (0.18 μM) and CK1δ/ε (0.4 μM). (R)-CR8 trihydrochloride induces apoptosis and has neuroprotective effect . (R)-CR8 trihydrochloride acts as a molecular glue degrader that depletes cyclin K .
1
1 Cited Publications
Cat. No.: HY-P70933
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HSPB8; Alpha-Crystallin C Chain; Heat Shock Protein Family B (Small) Member 8; Protein Kinase H11; E2IG1; HSPB8-N1; HSP22; HSPB8-N2; CMT2L; DHMN2; H11; HMN2A; Small Stress Protein-Like Protein HSP22; HMND2; Heat Shock Protein Family B Member 8; MFM13; Hea
Species:
Human
Source:
E. coli
Cat. No.: HY-N9331
CAS No.: 163046-73-9
Synonyms: Cimicidanol-3-O-β-d-xyloside
Category:
Triterpenes Plant Terpenoids Metabolic Disease Cimicifuga foetida Linn. Extract Disease Research Fields Ranunculaceae Extract
Target:
Cat. No.: HY-RS05945
Target:
Research Areas:
H1-1 Human Pre-designed siRNA Set A contains three designed siRNAs for H1-1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-135180
CAS No.: 914613-35-7
Target:
Research Areas:
1H-1-Ethyl Candesartan Cilexetil is a potential impurity found in bulk preparations of Candesartan Cilexetil (HY-17505).
Target:
Research Areas:
Thiazinamium (chloride) possesses potent anticholinergic and antiallergic activity and inhibits TxB2 synthesis with IC50 value of 0.2 µM. Thiazinamium (chloride) is structurally similar to H-1 antagonists Promethazine (HY-B1296). Thiazinamium (chloride) stimulates the phosphatidylcholine secretion in adult rat type II pneumocytes .
Cat. No.: HY-RS06443
Target:
Research Areas:
HSPB8 Human Pre-designed siRNA Set A contains three designed siRNAs for HSPB8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-135180R
CAS No.: 914613-35-7
Target:
Research Areas:
1H-1-Ethyl Candesartan Cilexetil (Standard) is the analytical standard of 1H-1-Ethyl Candesartan Cilexetil. This product is intended for research and analytical applications. 1H-1-Ethyl Candesartan Cilexetil is a potential impurity found in bulk preparations of Candesartan Cilexetil (HY-17505).
Cat. No.: HY-132733S
CAS No.: 1246818-70-1
Cat. No.: HY-106465
CAS No.: 77650-95-4
Research Areas:
Proterguride is a potent dopamine receptor agonist. Proterguride also shows antagonistic properties at the histamine H(1) receptor and alpha(1)-adrenoceptor and partially agonize serotonergic 5-HT2A/B receptor. Proterguride can be used for the research of neurological disease, such as Parkinson's disease .
Cat. No.: HY-160125
CAS No.: 2154373-61-0
Target:
Research Areas:
25,25-Difluoro-27-norcholestenoic acid is an LXRb ligand that disrupts the His435-Trp457 aromatic-aromatic interaction, destabilizing the H11-H12 region and favoring corepressor binding .
Cat. No.: HY-RS18283
Target:
Research Areas:
Hspb8 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hspb8 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-135180S
CAS No.: 1246819-47-5
Cat. No.: HY-W075249
CAS No.: 1373155-12-4
Synonyms: 1,1,1,1-[1,1-Biphenyl]-3,3,5,5-tetrayltetrakis[1H -imidazole
3,3',5,5'-Tetra(1H-imidazol-1-yl)-1,1'-biphenyl (1,1,1,1-[1,1-Biphenyl]-3,3,5,5-tetrayltetrakis[1H -imidazole) is a metal-organic framework (MOF).
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
