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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
H1047R
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "H1047R" in MCE Product Catalog:
1
1 Cited Publications
PKI-179 is a potent and orally active dual PI3K/mTOR inhibitor, with IC50s of 8 nM, 24 nM, 74 nM, 77 nM, and 0.42 nM for PI3K-α, PI3K-β, PI3K-γ, PI3K-δ and mTOR, respectively. PKI-179 also exhibits activity over E545K and H1047R, with IC50s of 14 nM and 11 nM, respectively. PKI-179 shows anti-tumor activity in vivo .
1
1 Cited Publications
PKI-179 hydrochloride is a potent and orally active dual PI3K/mTOR inhibitor, with IC50s of 8 nM, 24 nM, 74 nM, 77 nM, and 0.42 nM for PI3K-α, PI3K-β, PI3K-γ, PI3K-δ and mTOR, respectively. PKI-179 hydrochloride also exhibits activity over E545K and H1047R, with IC50s of 14 nM and 11 nM, respectively. PKI-179 hydrochloride shows anti-tumor activity in vivo .
1
1 Cited Publications
Cat. No.: HY-P703580
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: PIK3CA; Phosphatidylinositol-4,5-Bisphosphate 3-Kinase; Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha; PI3-Kinase P110 Subunit Alpha; Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform; PtdIns-3-Kinase
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-157287
Target:
Research Areas:
(S)-Phe-A110/B319 is a selective binde that has 20-fold higher affinity towards the H1047R mutant of p110α in the p110α/p85α PI3K complex .
Cat. No.: HY-161373
CAS No.: 2925030-26-6
PI3Kα-IN-22 (Compound 17) is an orally active, potent and selective inhibitor of PI3Kα H1047R, with an IC50 of 1 nM for pAKT T47D AlphaLISA. PI3Kα-IN-22 can induce tumor regressions in the HCC1954 tumor model in mice .
Cat. No.: HY-157288
Target:
Research Areas:
(R)-Phe-A110/B319, a hapten, is a selective binder to tumor-associated antigens. (R)-Phe-A110/B319 has a 20-fold higher affinity towards the H1047R mutant of p110α in the p110α/p85α PI3K complex. (R)-Phe-A110/B319 can be used for the research of conditional chimeric antigen receptor T (CAR-T) cell activation and tumor targeting .
Cat. No.: HY-189880
PI3Kα-IN-36 is a selective and orally active PI3Kα H1047R inhibitor with a pAKT inhibition IC50 of 96 nM in T47D cells. PI3Kα-IN-36 selectively inhibits T47D cell proliferation with an IC50 of 65 nM. PI3Kα-IN-36 achieves 81% tumor growth inhibition in a T47D xenograft mouse model. PI3Kα-IN-36 can be used in research related to PI3Kα H1047R mutation-driven tumors .
Cat. No.: HY-184099
CAS No.: 3031974-57-6
Synonyms: zinilisibum
Zinilisib (Zinilisibum) is a PI3K inhibitor. Zinilisib potently inhibits the phosphorylation of AKT in cells expressing mutant PI3Kα H1047R and wild-type PI3Kα, with IC50 values of 1-500 nM and 2-15 μM, respectively. Zinilisib can be used in breast cancer-related research .
Cat. No.: HY-183285
CAS No.: 3057582-20-1
PI3Kα-IN-32 (Compound 11f) is a selective, orally active PI3Kα inhibitor, with an IC50 of 26.3 nM against PI3Kα H1047R. PI3Kα-IN-32 inhibits AKT phosphorylation. PI3Kα-IN-32 exhibits anticancer activity against breast cancer. PI3Kα-IN-32 can be used in the research of HR +/HER2 - breast cancer .
Cat. No.: HY-11080AR
CAS No.: 1463510-35-1
Target:
Research Areas:
PKi-179 hydrochloride (Standard) is the analytical standard of PKi-179 (hydrochloride) (HY-11080A). This product is intended for research and analytical applications. PKi-179 hydrochloride is a potent and orally active dual PI3K/mTOR inhibitor, with IC50s of 8 nM, 24 nM, 74 nM, 77 nM, and 0.42 nM for PI3K-α, PI3K-β, PI3K-γ, PI3K-δ and mTOR, respectively. PKi-179 hydrochloride also exhibits activity over E545K and H1047R, with IC50s of 14 nM and 11 nM, respectively. PKi-179 hydrochloride shows anti-tumor activity in vivo .
Cat. No.: HY-11080R
CAS No.: 1197160-28-3
Target:
Research Areas:
PKi-179 (Standard) is the analytical standard of PKi-179 (HY-11080). This product is intended for research and analytical applications. PKi-179 is a potent and orally active dual PI3K/mTOR inhibitor, with IC50s of 8 nM, 24 nM, 74 nM, 77 nM, and 0.42 nM for PI3K-α, PI3K-β, PI3K-γ, PI3K-δ and mTOR, respectively. PKi-179 also exhibits activity over E545K and H1047R, with IC50s of 14 nM and 11 nM, respectively. PKi-179 shows anti-tumor activity in vivo .
Cat. No.: HY-179623
PI3Kα-IN-29 is a potent, orally active and selective PI3Kα with an IC50 of 2.5 nM. PI3Kα-IN-29 exhibits >400-fold selectivity over PI3Kβ/δ/γ/mTOR. PI3Kα-IN-29 selectively degrades the H1047R mutant p110α protein and inhibits PI3Kα kinase activity. PI3Kα-IN-29 suppresses PI3K/AKT/mTOR signaling, induces G1 arrest, and inhibits migration. PI3Kα-IN-29 inhibits tumor growth in a T47 mouse model. PI3Kα-IN-29 can be used for the research of breast cancer .
Cat. No.: HY-P810808
Synonyms: PI3-kinase subunit alpha, PI3K-alpha, PI3Kalpha, PtdIns-3-kinase subunit alpha, Phosphoinositide 3-kinase alpha, Phosphoinositide-3-kinase catalytic alpha polypeptide, Serine/threonine protein kinase PIK3CA, PtdIns-3-kinase subunit p110-alpha, p110alpha, PIK3CA
Cat. No.: HY-P703466
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PIK3R1; PI3-Kinase Subunit P85-Alpha; Phosphoinositide-3-Kinase Regulatory Subunit 1; PI3 Kinase-Associated P85; GRB1; CDNA FLJ44373 Fis, Clone TRACH3009455, Highly Similar To Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha; Phosphatidylinositol 3-Kinase 85 KDa Regulatory Subunit Alpha; Phosphatidylinositol 3-Kinase, Regulatory Subunit, Polypeptide 1 (P85 Alpha); Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha; Phosphatidylinositol 3-Kinase-Associated P-85 Alpha; P85-ALPHA; PtdIns-3-Kinase Regulatory Subunit P85-Alpha; P85alpha; Phosphoinositide-3-Kinase Regulatory Subunit; P85; PI3-Kinase Regulatory Subunit Alpha; Phosphoinositide-3-Kinase, Regulatory Subunit 1 (Alpha); PIK3R1/NR4A3 Fusion Protein; Phosphoinositide-3-Kinase Regulatory Subunit Alpha; NR4A3 Fusion; PtdIns-3-Kinase Regulatory Subunit Alpha; IMD36; Growth Factor Receptor Bound 1; AGM7; PI3K Regulatory Subunit Alpha; MHC class I antigen; MHC class I protein; Mamu-A1; Mamu-A
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P706085
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: MHC class I antigen; MHC class I protein; Mamu-A1; Mamu-A; PIK3R1; PI3-Kinase Subunit P85-Alpha; Phosphoinositide-3-Kinase Regulatory Subunit 1; PI3 Kinase-Associated P85; GRB1; CDNA FLJ44373 Fis, Clone TRACH3009455, Highly Similar To Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha; Phosphatidylinositol 3-Kinase 85 KDa Regulatory Subunit Alpha; Phosphatidylinositol 3-Kinase, Regulatory Subunit, Polypeptide 1 (P85 Alpha); Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha; Phosphatidylinositol 3-Kinase-Associated P-85 Alpha; P85-ALPHA; PtdIns-3-Kinase Regulatory Subunit P85-Alpha; P85alpha; Phosphoinositide-3-Kinase Regulatory Subunit; P85; PI3-Kinase Regulatory Subunit Alpha; Phosphoinositide-3-Kinase, Regulatory Subunit 1 (Alpha); PIK3R1/NR4A3 Fusion Protein; Phosphoinositide-3-Kinase Regulatory Subunit Alpha; NR4A3 Fusion; PtdIns-3-Kinase Regulatory Subunit Alpha; IMD36; Growth Factor Receptor Bound 1; AGM7; PI3K Regulatory Subunit Alpha
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
