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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
Hsp70-Bim
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "Hsp70-Bim" in MCE Product Catalog:
Cat. No.: HY-163854
CAS No.: 3048341-44-9
HSP70-IN-6 (JL-15) is an inhibitor of Hsp70-Bim protein-protein interaction, with an IC50 value of 0.07 μM against Hsp70-Bim PPI, an IC50 of 4.89 μM and a Kd of 0.123 μM for BimBH3-stimulated Hsp70 ATPase activity. HSP70-IN-6 selectively blocks the binding of Hsp70-Bim without affecting the Hsp70-Bag3 interaction, and inhibits BimBH3-stimulated Hsp70 ATPase activity but has no impact on basal ATPase activity. HSP70-IN-6 induces apoptosis (apoptosis) in chronic myeloid leukemia cells in an Hsp70-Bim-dependent manner. HSP70-IN-6 can be used in research related to chronic myeloid leukemia .
Cat. No.: HY-162008
CAS No.: 3032432-71-3
S1g-10 is an Hsp70-Bim protein-protein interaction inhibitor and an Hsp70 ATPase inhibitor. S1g-10 binds the Hsp70 nucleotide-binding domain at the Bim interface, inhibits Bim-stimulated ATPase activity, and selectively disrupts Hsp70-Bim without affecting Hsp70-Bag3, thereby inhibiting mitophagy (Autophagy), inducing apoptosis (Apoptosis), and reducing the survival and self-renewal of CML leukemia stem cells. S1g-10 can be used for research on chronic myeloid leukemia and breast cancer .
Cat. No.: HY-189700
CAS No.: 3048341-50-7
Research Areas:
JL-15-DNBS is an Hsp70-Bim interaction disruptor. JL-15-DNBS undergoes GSH-responsive activation to release active JL-15, and GSH depletion attenuates its cytotoxicity. JL-15-DNBS downregulates the oncogenic client proteins AKT and eIF4E. JL-15-DNBS can be used for research on chronic myeloid leukemia (CML) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
