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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
KMS11
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "KMS11" in MCE Product Catalog:
Target:
Research Areas:
UNC6934 is a selective NSD2-PWWP1 antagonist with a Kd of 91 nM against human targets. UNC6934 binds to the canonical methyl-lysine binding pocket of NSD2-PWWP1 and directly competes with H3K36me2 for binding. UNC6934 induces the aggregation of NSD2 within the nucleolus, without altering ribosomal RNA transcription, global H3K36me2 levels or the proliferation of KMS-11 cells. UNC6934 can be used in studies related to multiple myeloma and diffuse intrinsic pontine glioma .
Cat. No.: HY-189023
CAS No.: 3078788-63-0
Target:
Research Areas:
ND-L11A TFA is the R-configured enantiomer of the NSD2 degrader ND-L11, with KD >100 μM. ND-L11A TFA fails to induce significant NSD2 protein degradation in multiple myeloma KMS11 cells and shows no significant antiproliferative effect on NSD2-driven KMS11 cells. ND-L11A TFA can be used in the study of multiple myeloma .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
