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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
287 Results for "
Ketone
" in MedChemExpress (MCE) Product Catalog:
Products (287)
287 Results for "Ketone" in MCE Product Catalog:
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Imidazole ketone erastin is a potent, selective, and metabolically stable inhibitor of the cystine-glutamate antiporter, system xc - and an activator of ferroptosis. Imidazole ketone erastin has anti-tumor activity .
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Quinones Terpenoids Samanea saman (Jacq.) Merr. Diterpenoids Plants Disease Research Fields Naphthalene Quinones Cancer Labiatae Extract
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7 Cited Publications
Synonyms: Arachidonyl trifluoromethyl Ketone
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AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeant trifluoromethyl ketone analog of arachidonic acid. AACOCF3 is a potent and selective slow binding inhibitor of the 85-kDa cytosolic phospholipase A2 (cPLA2). AACOCF3 blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. AACOCF3 inhibits glucose-induced insulin secretion from isolated rat islets. AACOCF3 has the potential for the research of cardiovascular disease .
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7 Cited Publications
Synonyms: 3β-Hydroxy-5-pregnen-20-one monosulfate sodium
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7 Cited Publications
Synonyms: 3β-Hydroxy-5-pregnen-20-one monosulfate
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5
5 Cited Publications
Cat. No.: HY-W115718
CAS No.: 370-81-0
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Cuprizone is a copper chelating agent that forms a deep blue copper ketone complex with copper (II). The copper ketone reaction can be used in colorimetric tests for the presence of trace copper. Cuprizone can be used to induce some schizophrenia-like behavior in mice. Cuprizone acts on copper enzymes, including SOD1, cytochrome oxidase, and DβH, thereby causing oxidative stress and increasing DA levels in certain brain regions such as the medial prefrontal cortex (PFC) .
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4 Cited Publications
Cat. No.: HY-122542A
CAS No.: 82188-90-7
Synonyms: Pebac; D-Phenylalanyl-prolyl-arginyl Chloromethyl Ketone; D-Phe-Pro-Arg-CH2Cl
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PPACK dihydrochloride is a potent, peptidic inhibitor targeting thrombin and granzyme GZMK. PPACK dihydrochloride specifically blocks the activities of thrombin and GZMK, thereby inhibiting thrombin-mediated PAR-1 cleavage, as well as downstream inflammatory and procoagulant signaling pathways. Through stabilizing IκB proteins, blocking NF-κB activation and reducing systemic levels of proinflammatory/procoagulant biomarkers, PPACK dihydrochloride exerts multiple effects including anti-inflammatory, antithrombotic, barrier repair, and inhibition of atherosclerotic plaque progression. PPACK dihydrochloride binds to platelets without interference from kininogen, effectively limiting acute thrombus growth and reducing eosinophil infiltration and goblet cell hyperplasia in asthma models. PPACK dihydrochloride is an important tool molecule for investigating the mechanisms of atherosclerosis, asthma and related thromboinflammatory diseases .
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3 Cited Publications
Cat. No.: HY-W028393
CAS No.: 392-12-1
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N-alpha-Tosyl-L-lysine chloromethyl ketone (TLCK), a trypsin like protease inhibitor, sensitizes HeLa cells to Fas-mediated cell death.
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2 Cited Publications
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Ketone monoester is an orally available ketone monoester that serves as a source of nutritional ketones. Ketone monoester increases plasma beta-hydroxybutyrate, acetoacetate, blood glucose, blood sodium, and blood creatinine levels in mouse models. Ketone monoester has the potential to improve athletic performance and endurance in animals. Ketone monoester partially prevents myasthenia in septic mice. Ketone monoester may also be used to study Parkinson's disease or diabetes .
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1 Cited Publications
Cat. No.: HY-N6069
CAS No.: 38963-94-9
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Ketones, Aldehydes, Acids Rosaceae Extract Plants Rubus corchorifolius Linn. f. Disease Research Fields Inflammation/Immunology
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1
1 Cited Publications
Synonyms: L-1-Tosylamido-2-phenylethyl chloromethyl Ketone; L-TPCK
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Infection Neurological Disease Inflammation/Immunology Cancer
TPCK (L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK) is an effective serine protease inhibitor and also a blocker of the PDK1/Akt pathway. TPCK can modify the E7 protein in actively keratinocyte cells. TPCK can induce cellular apoptosis, suppress tumor growth, reduce hypoxic-ischemic brain injury in rat pups, and affect vascular permeability in inflamed rats .
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1 Cited Publications
Synonyms: Frambione; 4-(4-Hydroxyphenyl)-2-butanone
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Cardiovascular Disease Monophenols Rubus idaeus Linn. Rosaceae Extract Phenols Plants Disease Research Fields
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1
1 Cited Publications
Synonyms: Boc-Asp(OMe)-FMK
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Boc-Asp(OME)-Fluoromethyl Ketone is a broad range caspase inhibitor that inhibits Fas-mediated phagocytosis and oxidative rupture inhibition, but does not affect the chemotactic activity of IL-8 .
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Musk ketone is a widely used artificial fragrance. Musk ketone is also a cytochrome P450 enzyme inducer. Musk ketone shows mutagenic and comutagenic effects in Hep G2 cells and induces neural stem cell proliferation and differentiation in cerebral ischemia via activation of the PI3K/Akt signaling pathway. In the brain, musk ketone is neuroprotective against stroke injury through inhibition of cell apoptosis .
1
1 Cited Publications
Cat. No.: HY-W016622
CAS No.: 28940-11-6
Synonyms: 7-Methyl-2H-1,5-benzodioxepin-3(4H)-one
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Watermelon ketone (7-Methyl-2H-1,5-benzodioxepin-3(4H)-one) is a compound with a fresh marine scent .
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4,4'-Dichlorobenzophenone (Bis (4-chlorophenyl) ketone) is an ERα/ERβ agonist with IC50 values of 40.86 μM and 24.11 μM, respectively. 4,4'-Dichlorobenzophenone induces ER-dependent cancer cell proliferation after long-term exposure. 4,4'-Dichlorobenzophenone can be used for research on breast cancer .
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1 Cited Publications
Cat. No.: HY-34619
CAS No.: 27126-76-7
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1 Cited Publications
Category:
Ketones, Aldehydes, Acids Disease markers Metabolic Disease Endocrine diseases Endogenous metabolite Disease Research Fields
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
