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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
LTβR
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "LTβR" in MCE Product Catalog:
3
Target:
Research Areas:
Target:
Research Areas:
LTβR-IN-1 (Compound 919278) is a potent, selective lymphotoxin β receptor (LTβR) inhibitor. LTβR-IN-1 also selectively inhibits the nuclear translocation of p52 depended on TNF12A, instead of the nuclear translocation of p65 mediated by TNF-α receptor. LTβR-IN-1 regulates the NF-kB signaling pathway IN a ligand-independent manner .
Cat. No.: HY-115454A
Purity: 99.26%
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
GB111-NH2 hydrochloride is a covalent cysteine cathepsin inhibitor. GB111-NH2 hydrochloride blocks cathepsin B/L/S activity, probe binding, and BMV109 signal in biopsy tissue. GB111-NH2 hydrochloride blocks brain cathepsin GB123 binding under ex vivo conditions. GB111-NH2 hydrochloride induces oxidative stress, autophagy inhibition, apoptosis, proliferation/S-phase entry, arginase activity, and non-autonomous apoptosis of neighboring tumor cells. GB111-NH2 hydrochloride reduces primary breast tumor volume, causes tumor regression, and alters macrophage morphology. GB111-NH2 hydrochloride restores marginal zone architecture and elevates lymphotoxin α (LTα) and splenic lymphotoxin β receptor (LTβR) signaling. GB111-NH2 hydrochloride can be used for research on chronic epilepsy, breast cancer, and atherosclerosis .
Cat. No.: HY-115454
CAS No.: 956479-18-8
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
GB111-NH2 is a covalent cysteine cathepsin inhibitor. GB111-NH2 blocks cathepsin B/L/S activity, probe binding, and BMV109 signal in biopsy tissue. GB111-NH2 blocks brain cathepsin GB123 binding under ex vivo conditions. GB111-NH2 induces oxidative stress, autophagy inhibition, apoptosis, proliferation/S-phase entry, arginase activity, and non-autonomous apoptosis of neighboring tumor cells. GB111-NH2 reduces primary breast tumor volume, causes tumor regression, and alters macrophage morphology. GB111-NH2 restores marginal zone architecture and elevates lymphotoxin α (LTα) and splenic lymphotoxin β receptor (LTβR) signaling. GB111-NH2 can be used for research on chronic epilepsy, breast cancer, and atherosclerosis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
