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1 Result for "
Mezigdomide derivative1
" in MedChemExpress (MCE) Product Catalog:
Products (1)
1 Results for "Mezigdomide derivative1" in MCE Product Catalog:
Cat. No.: HY-190182
CAS No.: 2771847-91-5
Synonyms: CC-92480 derivative-1
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Research Areas:
Mezigdomide derivative-1 (CC-92480 derivative-1) is a chiral α-methylglutarimide analog of Mezigdomide (HY-129395) and belongs to the CELMoD (CRBN E3 ubiquitin ligase modulator) class. After the introduction of a methyl group to lock the chirality, Mezigdomide derivative-1 almost completely loses CRBN binding and Aiolos protein degradation activity, indicating that this chiral site does not tolerate methyl substitution. Mezigdomide derivative-1 can be used for structure-activity relationship studies .
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