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27 Results for "

Myotonic

" in MedChemExpress (MCE) Product Catalog:

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BDP9066

3 Cited Publications

Cat. No.: HY-111424

CAS No.: 2226507-04-4

Purity: 98.18%

Target:

Cdc42-binding kinase

Research Areas:

Cancer

BDP9066 is a potent and selective myotonic dystrophy-related Cdc42-binding kinase MRCK inhibitor with an IC₅₀ of 64 nM for MRCKβ in SCC12 cells, K_i values of 0.0136 nM and 0.0233 nM for MRCKα/β in house determinations, respectively. BDP9066 has therapeutic effect on skin cancer by reducing substrate phosphorylation.

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Baliforsen

Cat. No.: HY-145725A

CAS No.: 1698048-23-5

Synonyms: ISIS 598769; IONIS 598769; BIIB 065; ISIS-DMPK-2.5Rx

Target:

Ser/Thr Kinase

Research Areas:

Neurological Disease

Baliforsen (ISIS 5987690) is an antisense oligonucleotide (ASO) that inhibits DMPK mRNA. Baliforsen binds within exon 9 of the human DMPK transcript to promote RNase H1-mediated degradation Baliforsen can be used for the research of myotonic dystrophy type 1 .

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Baliforsen sodium

DNA, d(P-thio)([2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]m5rC-(3′→4′)-[2′,5′-anhydro-6′-deoxy-4′-C-(hydroxymethyl)-α-L-mannofurano]m5C-(3′→4′)-[2′,5′-anhydro-6′-deoxy-4′-C-(hydroxymethyl)-α-L-mannofurano]m5C-G-A-A-T-G-T-m5C-m5C-(3′→4′)-[2′,5′-anhydro-6′-deoxy-4′-C-(hydroxymethyl)-α-L-mannofurano]G-(3′→4′)-[2′,5′-anhydro-6′-deoxy-4′-C-(hydroxymethyl)-α-L-mannofurano]A-[2′-O-(2-methoxyethyl)]m5rC-[2′-O-(2-methoxyethyl)]rA), sodium salt (1:15)

Cat. No.: HY-145725

CAS No.: 1687746-79-7

Purity: 95.23%

Synonyms: IONIS 598769 sodium; ISIS 598769 sodium

Baliforsen (sodium) is an antisense oligonucleotide (16 nucleotides) designed to target myotonic dystrophy protein kinase (DMPK) mRNA and research myotonic dystrophy.

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Delpacibart zotadirsen

Cat. No.: HY-177564

CAS No.: 2929240-20-8

Synonyms: Del-zota; AOC 1044

Target:

Antibody-Oligonucleotide Conjugates (AOCs) Transferrin Receptor Dystrophin Antibody-Drug Conjugates (ADCs)

Research Areas:

Neurological Disease

Delpacibart zotadirsen (Del-zota), an antibody oligonucleotide conjugate (AOC), consists of a monoclonal antibody (Delpacibart) (HY-P990051) that binds to the transferrin receptor 1 (TfR1) conjugated to a phosphorodiamidate morpholino conjugate (PMO), Delpacibart zotadirsen is designed to deliver phosphorodiamidate morpholino oligomers (PMOs) to skeletal muscle and heart tissue to specifically skip exon 44 of the dystrophin gene and enable production of near-full length dystrophin. Delpacibart zotadirsen is used for the study of myotonic dystrophy type 1 (DM1) .

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Basivarsen linker

Cat. No.: HY-177454

CAS No.: 2763758-01-4

Target:

Antibody-Oligonucleotide Conjugates (AOCs)

Research Areas:

Others

Basivarsen linker is a linker used in HY-177452 Zeleciment basivarsen for coupling a TfR1-binding Fab Zeleciment (HY-P990780) and an antisense oligonucleotide. Zeleciment basivarsen is an antibody-oligonucleotide conjugate (AOC) designed to target mutant nuclear myotonic dystrophy protein kinase (DMPK) RNA for RHase H-mediated degradation to correct splicing. It is used for the study of myotonic dystrophy type 1 (DM1).

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BDP8900

Cat. No.: HY-111423

CAS No.: 2226507-05-5

Target:

Cdc42-binding kinase

Research Areas:

Cancer

BDP8900 is a potent and selective inhibitor of myotonic dystrophy-related Cdc42-binding kinases (MRCKα and MRCKβ). BDP8900 reduces substrate phosphorylation, leading to morphological changes, motility inhibition and invasiveness of cancer cells .

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