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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
26 Results for "
NTS
" in MedChemExpress (MCE) Product Catalog:
Products (26)
26 Results for "NTS" in MCE Product Catalog:
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1 Cited Publications
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SR 142948A is a blood-brain barrier-permeable, orally active, selective, non-peptide Neurotensin Receptor antagonist. SR 142948A exhibits an IC50 of 4.0 nM at the NTS1 site. SR 142948A competitively antagonizes neurotensin-dependent neurotransmitter release and modulates neurotensin-related dopaminergic and serotonergic signaling, making it useful for research on neurobehavioral mechanisms associated with schizophrenia .
Synonyms: PG(16:0/18:1) sodium; 1-Palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) sodium
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POPG (sodium) is a negatively charged phospholipid. POPG (sodium) affects the interactions of membrane proteins with other molecules by changing the charge characteristics of the lipid environment. POPG (sodium) increases the apparent affinity of Gαq and Gβ1γ1 for activated NTS1. POPG (sodium) can interact with the positive charge of peptides. POPG sodium salt can be used in Parkinson's disease research .
Cat. No.: HY-P10275
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Cat. No.: HY-137002
CAS No.: 913733-27-4
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Cat. No.: HY-P2544
CAS No.: 139026-64-5
Synonyms: JMV438
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LY-272015 hydrochloride is an orally active and selective 5-HT2B receptor antagonist. LY-272015 hydrochloride blocks 5-HT2 receptors and inhibits Fluoxetine (HY-B0102)-induced PDGFβ receptor transactivation. LY-272015 hydrochloride attenuates 5-HT-induced smooth muscle cell migration and proliferation, and inhibits downstream mTOR/p70S6K phosphorylation. LY-272015 hydrochloride reduces 5-HT-induced vasoconstriction. LY-272015 hydrochloride reverses the excitatory effect of BW-723C86 (HY-101369) on NTS neurons. LY-272015 hydrochloride lowers mean arterial blood pressure in severely hypertensive DOCA-salt rats. LY-272015 hydrochloride can be used in research related to diseases such as hypertension and cardiovascular calcification .
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NTRC-824 (Compound 5) is a potent, selective and neurotensin-like nonpeptide neurotensin receptor type 2 (NTS2) antagonist with an IC50 of 38 nM and a Ki of 202 nM. NTRC-824 is >150-fold selectivity for NTS2 over NTS1 (Ki >30 μM) .
Cat. No.: HY-124831
CAS No.: 1811503-67-9
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NTRC-844 (compound 8) is a selective antagonist of neurotensin receptor type 2 (NTS2),with the EC50 of 238 nM. NTRC-844 plays an important role in analgesic animal research .
Cat. No.: HY-137525
CAS No.: 1643879-88-2
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NTRC-808 is a nonpeptide selective GPCR neurotensin receptor type 2 (NTS2) partial agonist with an EC50 of 14 nM and Ki of 88 nM. NTRC-808 has higher selectivity for NTS2 than for NTS1. NTRC-808 has antipsychotic and analgesic activity .
Cat. No.: HY-P991147
CAS No.: 2769743-01-1
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Cat. No.: HY-P10767
CAS No.: 2468971-42-6
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Cat. No.: HY-175184
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LSD1-IN-44 (Compound 19) is a LSD1 inhibitor with an IC50 of 0.02 μM for LSD1-CoREST enzymatic complex. LSD1-IN-44 has significant antischistosomal activity against transformed schistosomula (NTS) and Schistosoma mansoni adult worms while showing a delayed onset of action towards juvenile forms. LSD1-IN-44 has no significant toxicity to human cells. LSD1-IN-44 can be used for schistosomiasis research .
Cat. No.: HY-RS24084
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Nts Rat Pre-designed siRNA Set A contains three designed siRNAs for Nts gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-12217
CAS No.: 1612188-96-1
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NTRC-739 is a selective nonpeptide partial neurotensin receptor type 2 (NTS2) agonist with an EC50 of 12 nM and a Ki of 153 nM. NTRC-739 is 161-fold selective for NTS2 versus NTS1. NTRC-739 can be used for the study of chronic pain research .
Cat. No.: HY-175185
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MC3935 is a LSD1 inhibitor with an IC50 of 0.52 μM for LSD1-CoREST enzymatic complex. MC3935 has significant antischistosomal activity against transformed schistosomula (NTS) and Schistosoma mansoni adult worms while showing a delayed onset of action towards juvenile forms. MC3935 has no significant toxicity to human cells. MC3935 can be used for schistosomiasis research .
Cat. No.: HY-P2025
CAS No.: 113137-57-8
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Cat. No.: HY-RS09637
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NTS Human Pre-designed siRNA Set A contains three designed siRNAs for NTS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS17624
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Nts Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nts gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-100851
CAS No.: 159730-07-1
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LY-272015 is an orally active and selective 5-HT2B receptor antagonist. LY-272015 blocks 5-HT2 receptors and inhibits Fluoxetine (HY-B0102)-induced PDGFβ receptor transactivation. LY-272015 attenuates 5-HT-induced smooth muscle cell migration and proliferation, and inhibits downstream mTOR/p70S6K phosphorylation. LY-272015 reduces 5-HT-induced vasoconstriction. LY-272015 reverses the excitatory effect of BW-723C86 (HY-101369) on NTS neurons. LY-272015 lowers mean arterial blood pressure in severely hypertensive DOCA-salt rats. LY-272015 can be used in research related to diseases such as hypertension and cardiovascular calcification .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
