76 Results for "

P388 leukemia

" in MedChemExpress (MCE) Product Catalog:
Products (76)

76 Results for "P388 leukemia" in MCE Product Catalog:

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4
4 Cited Publications
Cat. No.: HY-N0128
CAS No.: 515-03-7
Sclareol is isolated from Salvia sclarea with anticarcinogenic activity. Sclareol shows strong cytotoxic activity against mouse leukemia (P-388), human epidermal carcinoma (KB) cells and human leukemia cell lines. Sclareol induces cell apoptosis .
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3
3 Cited Publications
Cat. No.: HY-N3308
CAS No.: 32383-76-9
Medicarpin is a flavonoid isolated from Medicago sativa. Medicarpin induces apoptosis and overcome multidrug resistance in leukemia P388 cells by modulating P-gp-mediated efflux of agents .
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2
2 Cited Publications
Cat. No.: HY-14769
CAS No.: 3432-99-3
Purity:  86.60%
Synonyms: 5,10-Methylenetetrafolate; ANX-510 free acid
Folitixorin (5,10-Methylenetetrafolate; ANX-510 free acid) is a reduced form of Folic acid (HY-16637) and a cofactor of thymidylate synthase . Folitixorin acts as an essential cofactor to promote the formation of a tight ternary complex between thymidylate synthase and FdUMP, thereby enhancing the inhibitory effect of FdUMP on thymidylate synthase. Folitixorin in combination with 5-fluorouracil and αVEGF reduces tumor volume in colorectal tumor models of nude mice. Folitixorin is used in related research on Yoshida sarcoma, P-388 leukemia, and colorectal cancer .
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1
1 Cited Publications
Cat. No.: HY-120504
CAS No.: 1202-66-0
Purity:  98.90%
Target:  

Bacterial

Research Areas:  

Infection Cancer

N-Acetyltyramine is a quorum-sensing inhibitor (QSI) compound produced by V. alginolyticus M3-10. N-Acetyltyramine is capable of inhibiting the QS of C. violaceum ATCC 12472. N-acetyltyramine reverses resistance in Doxorubicin-resistant leukemia P388 cells .
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Cat. No.: HY-108603
CAS No.: 87745-28-6
Synonyms: (+)-Bryostatin 2
Target:  

PKC

Research Areas:  

Cancer

Bryostatin 2 ((+)-Bryostatin 2) is a 20-membered ring lactone that can be found in Bryozoan Eugufa neritina L. Bryostatin 2 has the potential for the research of P-388 lymphocytic leukemia .
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Cat. No.: HY-103653
CAS No.: 251111-15-6
Target:  

MetAP

Research Areas:  

Cardiovascular Disease Cancer

CKD-731 is a Fumagillin (HY-B0751) analogue. CKD-731 inhibits the proliferation of calf pulmonary artery endothelial cells (CPAE), lymphoma EL-4 cells and murine leukemia P388D1 cells. CKD-731 exerts the effect of inhibiting MetAP-2 activity and blocking angiogenesis. CKD-731 can be used for the research of anti-angiogenesis-related cancer .
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Cat. No.: HY-12458
CAS No.: 118292-36-7
Target:  

DNA/RNA Synthesis

Research Areas:  

Infection Cancer

Pyrindamycin A is an antibiotic that inhibits DNA synthesis. Pyrindamycin A shows antitumor activities against murine leukemia, exhibits stronger cytotoxic activities towards murine and human tumor cell lines and especially towards doxorubicin-resistant cells, inhibits P388 and P388/ADR cells with the same IC50 of 3.9 μg/ml .
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Cat. No.: HY-125037
CAS No.: 1190948-58-3
Diptoindonesin G is a 2-arylbenzofuran derivative and a modulator of estrogen receptor and HSP90 middle domain. Diptoindonesin G exhibits strong cytotoxicity against mouse leukemia P-388 cells with an IC50 of 13.2 μM. Diptoindonesin G has antitumor activity and can be used in the research of tumors such as breast cancer .
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Cat. No.: HY-121123
CAS No.: 42381-05-5
Purity:  ≥97.0%
Synonyms: 2-Aminoadamantane-2-carboxylic acid
Target:  

Aminopeptidase

Research Areas:  

Cancer

Adamantanine (2-Aminoadamantane-2-carboxylic acid) inhibits the transport of methionine (Ki is 0.76 mM) and leucine into Ehrlich ascites carcinoma cells. Adamantanine inhibits proliferation of P388 lymphocytic leukemia cells with an IC50 of >1 mM. Adamantanine inhibits the leucine aminopeptidase with an I/S0.5 of 10.5 .
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Cat. No.: HY-114648
CAS No.: 339300-34-4
Target:  

Bacterial

Research Areas:  

Infection Cancer

AJI-9561 is a benzoxazole derivative produced by Streptomyces sp. AJI-9561 exhibits cytotoxicity and antibacterial activity. AJI-9561 inhibits the proliferation of Jurkat T cells and mouse P388 leukemia cells, with its IC50 being 0.88 and 1.63 μM respectively. AJI-9561 can be used for research on anti-cancer and antibacterial properties .
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Cat. No.: HY-14769A
CAS No.: 133978-75-3
Synonyms: 5,10-Methylenetetrafolate calcium; ANX-510
Target:  

Thymidylate Synthase

Research Areas:  

Cancer

Folitixorin calcium (5,10-Methylenetetrafolate calcium; ANX-510) is a reduced form of Folic acid (HY-16637) and a cofactor of thymidylate synthase . Folitixorin calcium acts as an essential cofactor to promote the formation of a tight ternary complex between thymidylate synthase and FdUMP, thereby enhancing the inhibitory effect of FdUMP on thymidylate synthase. Folitixorin calcium in combination with 5-fluorouracil and αVEGF reduces tumor volume in colorectal tumor models of nude mice. Folitixorin calcium is used in related research on Yoshida sarcoma, P-388 leukemia, and colorectal cancer .
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Cat. No.: HY-117783
CAS No.: 126262-07-5
Target:  

Antibiotic

Research Areas:  

Infection

Y-05460M-A is a substituted isocoumarin antibiotic. Y-05460M-A exhibits inhibitory activity against Gram-positive and Gram-negative bacteria. Y-05460M-A is cytotoxic against P388 lymphatic leukemia. Y-05460M-A also has antiulcer activity. Y-05460M-A is a one-carbon lower homologue of PM-04128. Y-05460M-A can be achieved from N-Boc-L-valine .
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Cat. No.: HY-113771
CAS No.: 99260-70-5
Saquayamycin C has antimicrobial effect, but it has weaker effect against Gram-negative bacteria. Saquayamycin C has inhibitory effect on leukemia P388 cells and Adriamycin-resistant P388 cells .
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Cat. No.: HY-N13868
CAS No.: 99260-69-2
Saquayamycin C1 has antimicrobial effect, but it has weaker effect against Gram-negative bacteria. Saquayamycin C1 has inhibitory effect on leukemia P388 cells and Adriamycin-resistant P388 cells .
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Cat. No.: HY-N13870
CAS No.: 99260-66-9
Target:  

Bacterial

Saquayamycin A1 has antimicrobial effect, but it has weaker effect against Gram-negative bacteria. Saquayamycin A1 has inhibitory effect on leukemia P388 cells and Adriamycin-resistant P388 cells .
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Cat. No.: HY-N13941
CAS No.: 57765-71-6
Target:  

Bacterial

Baciphelacin is mainly resistant to gram-positive bacteria and has the activity of inhibiting Newcastle disease virus and leukemia P-388 cells .
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Cat. No.: HY-N14621
CAS No.: 321868-49-9
Target:  

Others

Harzialacton A has weak cytotoxicity to P388 leukemia cells with ED50 of > 100 μg/mL .
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Cat. No.: HY-N13878
CAS No.: 111278-00-3
Anguinomycin B is an antitumor antibiotic that shows highly cytotoxic to murine P388 leukemia cells .
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Cat. No.: HY-N14720
CAS No.: 86917-61-5
Demethylolivomycin A is an antitumor antibiotic. Demethylolivomycin A has anti-Gram-positive bacteria and anti-leukemia P388 activity .
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Cat. No.: HY-126170
CAS No.: 101961-60-8
Valanimycin is an antibiotic, which inhibits Escherichia coli (BE1121) through interaction with DNA. Valanimycin exhibits cytotoxicity to mouse leukemia L1210, P388/S (doxorubicin (HY-15142A)-sensitive), and P388/ADR (doxorubicin-resistant), with IC50 of 0.79, 2.65, and 1.44 μg/mL, respectively. Valanimycin exhibits antitumor efficacy against ehrlich ascites tumors or L1210 in mice .
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