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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
48 Results for "
PAI1
" in MedChemExpress (MCE) Product Catalog:
Products (48)
48 Results for "PAI1" in MCE Product Catalog:
Cat. No.: HY-P11413
CAS No.: 139446-70-1
Research Areas:
Cardiovascular Disease Metabolic Disease Inflammation/Immunology
PAI-1 is a serine protease inhibitor (SERPIN). PAI-1 binds to and irreversibly inhibits uPA, tPA and furin; it also interacts with vitronectin, α1-acid glycoprotein, CRT, TLR4, proteasome α-3 subunit, uPAR, LRP1, Integrin αvβ3 and thrombin. PAI-1 regulates fibrinolysis, extracellular matrix turnover, cell migration, angiogenesis, inflammatory response and tissue remodeling; it mediates epithelial-mesenchymal transition (EMT)/endothelial-mesenchymal transition (EndMT), apoptosis and thrombus stabilization. PAI-1 can be used in research related to sepsis, acute lung injury, cardiovascular diseases, tissue fibrosis, diabetic nephropathy, obstructive nephropathy and non-insulin-dependent diabetes mellitus [1] .
18
18 Publications Verification
Synonyms: PAI-039; Tiplasinin
Research Areas:
Tiplaxtinin is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 2.7 μM [1].
10
10 Cited Publications
Research Areas:
TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor-1 (PAI-1), has IC50 values between 13.9 and 51.1 μM and induces intrinsic apoptosis in several human cancer cell lines. TM5441 attenuates Nω-nitro-l-arginine methyl ester-induced cardiac hypertension and vascular senescence [1] .
5
5 Cited Publications
Target:
Research Areas:
TM5275 sodium can inhibit the interaction between PAI-1 and LRP1.
4
4 Cited Publications
Cat. No.: HY-N1504
CAS No.: 119425-90-0
Category:
Metabolic Disease Agavaceae Extract Dihydrochalcones Dracaena cochinchinensis (Lour.) S. C. Chen Extract Asparagaceae Extract Plant Flavonoids Monophenols Phenols Disease Research Fields
Target:
2
2 Cited Publications
Cat. No.: HY-P71077
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SERPINE1; Endothelial Plasminogen Activator Inhibitor; Prev. PLANH1; Serpin E1; Prev. PAI1; PAI-1; PAI; Serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1; Serine (Or Cysteine) Proteinase Inhibitor, Clade E (Nexi
Species:
Human
Source:
HEK293
1
Research Areas:
Drospirenone (Dihydrospirorenone) is an orally active fourth-generation progestin that interacts with the progesterone receptor (PR) and androgen receptor (AR). Drospirenone significantly decreases both plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (tPA) via the AR. Drospirenone can produce DNA damage in bone marrow cells of female mice. [1] .
1
Category:
Cardiovascular Disease Rutaceae Extract Toddalia asiatica (L.) Lam. Extract Plant Coumarins Phenylpropanoids Disease Research Fields
Target:
1
1
1 Cited Publications
Cat. No.: HY-P71133
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SERPINE1; Endothelial Plasminogen Activator Inhibitor; Prev. PLANH1; Serpin E1; Prev. PAI1; PAI-1; PAI; Serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1; Serine (Or Cysteine) Proteinase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1; Plasminogen Activator Inhibitor, Type I; Serpin Family E Member 1; Plasminogen Activator Inhibitor 1
Species:
Mouse
Source:
HEK293
Synonyms: PAZ-417
Research Areas:
Aleplastinin (PAZ-417) is an orally active, blood-brain barrier permeable, selective SERPINE1 (PAI-1) inhibitor (IC50=655 nM). Aleplastinin activates the tissue type plasminogen activator (tPA)/fibrinolysis cascade by inhibiting PAI-1, thereby promoting the degradation of amyloid-β (Aβ) oligomers and monomers. Aleplastinin can significantly reduce plasma and brain Aβ levels, improve memory impairment, and reverse cognitive impairment. Aleplastinin can be used for research on Alzheimer's disease [1] .
Synonyms: PAI-749
Target:
Research Areas:
Diaplasinin (PAI-749) is a plasminogen activator inhibitor-1 (PAI-1) inhibitor with IC50 of 295 nM. Diaplasinin has antithrombotic efficacy [1].
Research Areas:
MDI-2268 is an inhibitor of plasma kallikrein inhibitor 1 (PAI-1). MDI-2268 has good antithrombotic properties and regulates blood coagulation and fibrinolysis process by enhancing fibrinolysis. MDI-2268 can be used in research areas such as deep vein thrombosis [1].
Target:
Research Areas:
CDE-096 is a potent inhibitor of PAI-1. CDE-096 prevents PAI-1 from inactivating tPA and uPA with similar potency (IC50=30 and 25 nM, respectively) and is active against glycosylated PAI-1, as well as PAI-1 derived from several species (IC50=19, 22 and 18 nM for murine, rat, and Porcine PAI-1, respectively) [1].
Cat. No.: HY-165084
CAS No.: 383908-63-2
Synonyms: Soy PS sodium
Research Areas:
L-α-Phosphatidylserine sodium (Soy PS sodium) is a negatively charged phospholipid that acts as an allosteric activator to activate latent plasminogen activator inhibitor-1 (PAI-1). L-α-Phosphatidylserine does not directly alter the catalytic activity of t-PA, but regulates fibrinolytic activity solely by inducing conformational remodeling of PAI-1. L-α-Phosphatidylserine sodium is an antigen targeting phosphatidylserine (PS) and can induce the production of polyclonal antibodies. L-α-Phosphatidylserine is mainly used in studies related to immunology, fibrinolytic system and coagulation homeostasis [1].
Cat. No.: HY-P10887
CAS No.: 2988012-71-9
Synonyms: AV-001
Target:
Tie ANGPTL SARS-CoV Aquaporin TNF Receptor PAI-1 CXCR P-selectin
Research Areas:
Target:
Research Areas:
AZ3976 is a potent plasminogen activator inhibitor type 1 (PAI-1) inhibitor with an IC50 value of 26 μM in an enzymatic chromogenic assay. AZ3976 is active with an IC50 of 16 μM in a plasma clot lysis assay. AZ3976 does not bind to active PAI-1 but bound reversibly to latent PAI-1. AZ3976 inhibits PAI-1 by enhancing the latency transition of active PAI-1. AZ3976 displays profibrinolytic activities in a human plasma clot lysis assay [1].
Target:
Research Areas:
Anecortave acetate is a potent ocular angiostatic agent. Anecortave acetate inhibits neovascularization which is induced by many different angiogenic factors, and increases plasminogen activator inhibitor-1 (PAI-1) mRNA expression. Anecortave acetate can be used to research ocular neovascular diseases [1] .
Category:
Human Gut Microbiota Metabolites Monophenols Ketones, Aldehydes, Acids Phenols Microorganism Endogenous metabolite Disease Research Fields Inflammation/Immunology
Target:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
