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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
PDHC
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "PDHC" in MCE Product Catalog:
TM-1 is a potent inhibitor of pyruvate dehydrogenase kinase (PDHK1). TM-1 inhibits PDHK1 and PDHK2 with IC50s of 2.97 μM and 5.2 μM, respectively. TM-1 blocks pyruvate dehydrogenase complex (PDHC) phosphorylation, and inhibits cell proliferation .
Cat. No.: HY-176997
CAS No.: 3031881-21-4
PDHc-E2-IN-1 (Compound 9) is a Pyruvate Dehydrogenase Complex E2 (PDHc-E2) inhbibitor. with an IC50 of 2.52 μM. PDHc-E2-IN-1 shows strong antibacterial activity and can be used in the research of bacterial spot disease and bacterial leaf blight in rice .
Cat. No.: HY-174211
CAS No.: 1007786-48-2
JNK-IN-23 (Compound K12) is an inhibitor of JNK. JNK-IN-23 inhibits the proliferation of MDA-MB-231 (GIC50: 30 nM). JNK-IN-23 blocks TNBC metastatic growth in vivo. JNK-IN-23 inhibits the growth of lung metastases by dual targeting of glutaminase-1 (GLS) and pyruvate dehydrogenase complex (PDHC) .
Cat. No.: HY-189804
CAS No.: 2951082-10-1
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Antifungal agent 188 is an Antifungal agent. Antifungal agent 188 exhibits weak inhibitory activity against E. coli PDHc-E1, with IC50 = 59.7 μM. Antifungal agent 188 induces extensive ultrastructural damage in fungal hyphae, disrupting the cell wall and cell membrane. Antifungal agent 188 causes mitochondrial dysfunction and impaired energy production. Antifungal agent 188 induces ROS accumulation. Antifungal agent 188 interferes with glucan-related carbohydrate processes, reduces β-glucan (HY-W145521) content, and impairs cell wall integrity. Antifungal agent 188 is a potent in vitro inhibitor of M. fructicola and B. cinerea. Antifungal agent 188 can be used for research on peach brown rot .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
