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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
24 Results for "
PGK1
" in MedChemExpress (MCE) Product Catalog:
Products (24)
24 Results for "PGK1" in MCE Product Catalog:
17
17 Publications Verification
Synonyms: Compound 52
NG 52 is a potent, cell-permeable, selective, ATP-compatible and orally active Cdc28p and Pho85p kinase inhibitor with IC50s of 7 μM and 2 μM, respectively. NG 52 also inhibits the activity of phosphoglycerate kinase 1 (PGK1) with an IC50 of 2.5 μM. NG 52 is inactive against yeast kinases Kin28p, Srb10, and Cak1p [1] .
8
Category:
Rutaceae Extract Alkaloids Plant Evodia rutaecarpa (Juss.) Benth./Tetradium ruticarpum (A. Jussieu) T. G. Hartley Extract Disease Research Fields Cancer Indole Alkaloids
Target:
3
3 Cited Publications
Target:
Research Areas:
CBR-470-1 is an inhibitor of the glycolytic enzyme phosphoglycerate kinase 1 (PGK1). CBR-470-1 is also a non-covalent Nrf2 activator. CBR-470-1 protects SH-SY5Y neuronal cells against MPP +-induced cytotoxicity through activation of the Keap1-Nrf2 cascade [1] .
1
1 Cited Publications
Cat. No.: HY-W195984
CAS No.: 1016340-64-9
Target:
Research Areas:
Z57346765 is an inhibitor that targets the ADP-binding pocket of PGK1, with a Kd of 20.9 μM for human PGK1, and exhibits anticancer activity. Z57346765 reduces the activity of the metabolic enzyme PGK1 during glycolysis, regulates lipid peroxidation and cancer cell proliferation, and promotes lipid peroxidation in cervical cancer cells. Z57346765 inhibits the proliferation of cervical cancer and clear cell renal cell carcinoma cells in xenograft mouse models, and induces the expression of genes associated with cell metabolism, DNA replication and cell cycle. Z57346765 is used in research related to cervical cancer, clear cell renal cell carcinoma and breast cancer [1] .
Cat. No.: HY-178761
CAS No.: 3093312-81-0
Research Areas:
PGK1-IN-1 (Compound 6e) is a potent and selective PGK1 inhibitor (IC50: 33 nM). PGK1-IN-1 inhibits PGK1-mediated glycolytic metabolism and reduces glucose consumption/lactate production. PGK1-IN-1 enhances Nrf2 accumulation and HO-1 expression, and suppresses the transcription and protein levels of the inflammatory cytokines IL-1β and IL-6. PGK1-IN-1 ameliorates Dextran sulfate sodium (DSS) (HY-116282C)-induced experimental colitis in mice. PGK1-IN-1 can be used for research of inflammatory bowel disease (IBD) [1].
Cat. No.: HY-N8540
CAS No.: 12689-26-8
Category:
Cat. No.: HY-79722
CAS No.: 27489-62-9
Synonyms: trans-4-Aminocyclohexan-1-ol
Target:
Research Areas:
4-trans-Hydroxycyclohexylamine (trans-4-Aminocyclohexan-1-ol) is an intermediate. 4-trans-Hydroxycyclohexylamine is used in the synthesis of the PGK1 inhibitor Compd 25-4. 4-trans-Hydroxycyclohexylamine is used in research on EGFR-positive esophageal squamous cell carcinoma [1] .
Cat. No.: HY-178989
CAS No.: 3054148-68-1
Research Areas:
PGK1-IN-2 (Compound 60) is a PGK1 inhibitor with an IC50 of 8.24 μM. PGK1-IN-2 demonstrates a significant ability to inhibit the proliferation of osteosarcoma cells. PGK1-IN-2 interferes with the glycolytic pathway of tumor cells by inhibiting PGK1. PGK1-IN-2 inhibits cell migration and invasion, and induces cell S phase and G2-M phase cycle arrest. PGK1-IN-2 may kill cells by inducing cuproptosis. PGK1-IN-2 shows a significant anti-tumor effect in the MNNG-HOS osteosarcoma xenograft mouse model. PGK1-IN-2 can be used for the study of osteosarcoma [1].
Cat. No.: HY-RS16592
Target:
Research Areas:
Pgk1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pgk1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS10384
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Research Areas:
PGK1 Human Pre-designed siRNA Set A contains three designed siRNAs for PGK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23026
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Research Areas:
Pgk1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Pgk1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-177944
CAS No.: 2829198-49-2
Research Areas:
DC-PGKI is an orally active ATP-competitive PGK1 inhibitor(IC50 = 0.16 Μm, Kd = 99.08 nM). DC-PGKI stabilizes PGK1 in vitro and in vivo, and suppresses both glycolytic activity and the kinase function of PGK1. DC-PGKI-mediated inhibition of PGK1 leads to the accumulation of NRF2 (nuclear factor-erythroid factor 2-related factor 2, NFE2L2), which then translocates to the nucleus, binds to the proximal regions of IL-1β and IL-6 genes, and suppresses the LPS-induced expression of these genes. DC-PGKI can be used for the study of colitis [1].
Cat. No.: HY-184191
CAS No.: 1185003-32-0
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Research Areas:
PGK1-IN-3 is an orally active PGK1 inhibitor with human PGK1 IC50 values of 0.48 μM and human PGK1 Kd of 63 nM. PGK1-IN-3 binds to the ADP-binding pocket of PGK1, inhibits glycolysis, and reduces glucose consumption and lactate production. PGK1-IN-3 can be used for the research of pancreatic cancer [1].
Cat. No.: HY-127162
CAS No.: 69413-73-6
Synonyms: PGK1
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Research Areas:
Prostaglandin K1 (compound 46) is a structurally modified analog of prostacyclin (prostanoid) with an EC50 of 2800 nM for EP1 and a Ki of 2800 nM [1].
Category:
Rutaceae Extract Alkaloids Plant Evodia rutaecarpa (Juss.) Benth./Tetradium ruticarpum (A. Jussieu) T. G. Hartley Extract Indole Alkaloids
Target:
Cat. No.: HY-15154R
CAS No.: 212779-48-1
Synonyms: Compound 52 (Standard)
Target:
Research Areas:
NG 52 (Standard) is the analytical standard of NG 52. This product is intended for research and analytical applications. NG 52 is a potent, cell-permeable, selective, ATP-compatible and orally active Cdc28p and Pho85p kinase inhibitor with IC50s of 7 μM and 2 μM, respectively. NG 52 also inhibits the activity of phosphoglycerate kinase 1 (PGK1) with an IC50 of 2.5 μM. NG 52 is inactive against yeast kinases Kin28p, Srb10, and Cak1p [1] .
Cat. No.: HY-P71049
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PGK1; PGKA; Phosphoglycerate Kinase 1; Epididymis Secretory Sperm Binding Protein Li 68p; Cell Migration-Inducing Gene 10 Protein; Phosphoglycerate Kinase; Primer Recognition Protein 2; HEL-S-68p; PRP 2; MIG10
Species:
Human
Source:
HEK293
Cat. No.: HY-P74634
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: PGK1; PGKA; Phosphoglycerate Kinase 1; Epididymis Secretory Sperm Binding Protein Li 68p; Cell Migration-Inducing Gene 10 Protein; Phosphoglycerate Kinase; Primer Recognition Protein 2; HEL-S-68p; PRP 2; MIG10
Species:
Mouse
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
