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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
24 Results for "
PI(5)P
" in MedChemExpress (MCE) Product Catalog:
Products (24)
24 Results for "PI(5)P" in MCE Product Catalog:
2
2 Cited Publications
THZ-P1-2 is a first-in-class and selective PI5P4K inhibitor, with an IC50 of 190 nM for PI5P4Kα. THZ-P1-2 covalently targets cysteines on a disordered loop in PI5P4Kα/β/γ. THZ-P1-2 causes autophagy disruption and upregulates TFEB signaling. THZ-P1-2 displays anticancer activity in leukemia cell lines .
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1 Cited Publications
Synonyms: I-OMe-AG 538
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I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) is a specific inhibitor of IGF-1R (insulin-like growth factor-1 receptor tyrosine kinase). I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and is preferentially cytotoxic to nutrient-deprived PANC1 cells.?I-OMe-Tyrphostin AG 538 is an ATP-competitive inhibitor of phosphatidylinositol-5-phosphate 4-kinase α (PI5P4Kα), with an IC50?of 1 μM .
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NIH-12848 is a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor with an IC50 of 1 μM.
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ARUK2001607 is a selective phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor with a Kd of 7.1 nM. ARUK2001607 shows high selectivity over other >150 kinases .
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CC260 is a selective PI5P4Kα and PI5P4Kβ inhibitor with Kis of 40 nM and 30 nM, respectively. CC260 does not inhibit or weakly inhibits other protein kinases, such as Plk1 and RSK2. CC260 can be used for cell energy metabolism, diabetes and cancer research .
PI5P4Ks-IN-2 is a inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ). PI5P4Ks-IN-2 targets to PI5P4K isoforms with pIC50 values of <4.3 (PI5P4Kα), <4.6 (PI5P4Kβ), 6.2 (PI5P4Kγ), 0.32 (PI5P4Kγ+), respectively .
PI5P4Kγ-IN-1 is an ATP-competitive, highly selective chemical probe for PI5P4Kγ, with a Kd of 19 nM and an IC50 of 67 nM. PI5P4Kγ-IN-1 effectively inhibits PI5P4Kγ function and activates the mTORC1 signaling pathway in cells. PI5P4Kγ-IN-1 can be used in studies related to diseases such as breast cancer .
Cat. No.: HY-149659
Purity: 98.16%
ARUK2007145 is a PI5P4Kα and PI5P4Kγ inhibitor with pIC50 values of 7.3 and 8.1, respectively. ARUK2007145 is permeable, shows no efflux, has moderate solubility, and exhibits a high mouse liver microsomal metabolic rate. ARUK2007145 can be used in cancer-related research .
Synonyms: PI5P4Kα-IN-1
TM-04-176-01 (PI5P4Kα-IN-1) is a selective PIP4K2C inhibitor (Kd 3.4 nM) and PI5P4K inhibitor (IC50: 1.96 and 9.4 μM for PI5P4Kα and PI5P4Kβ, respectively). TM-04-176-01 inhibits SARS-CoV-2 replication with low cytotoxicity. TM-04-176-01 can be used for research on SARS-CoV-2 infection .
Cat. No.: HY-153529
CAS No.: 2471969-07-8
PI5P4Ks-IN-3 (compound 30) is a covalent inhibitor of PI5P4K with IC50s of 1.34 μM (PI5P4Kα)，and 9.9 μM (PI5P4Kβ)，respectively. PI5P4Ks-IN-3 shows weak cellular activity .
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D-myo-Inositol, 5-(dihydrogen phosphate) 1-[(2R)-2-[[(5Z,8Z,11Z,14Z)-1-oxo-5,8,11,14-eicosatetraen-1-yl]oxy]-3-[(1-oxooctadecyl)oxy]propyl hydrogen phosphate], ammonium salt (1:2)
Cat. No.: HY-157640
CAS No.: 2315262-43-0
Cat. No.: HY-146836S
Purity: ≥99.0%
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(Rac)-16:0 PI(5)P-d5 (ammonium) is deuterium labeled (Rac)-16:0 PI(5)P (ammonium).
Cat. No.: HY-146836S1
CAS No.: 2260669-80-3
Synonyms: 1,2-dipalmitoyl-rac-glycero(-d5)-3-phospho-(1'-myo-inositol-5'-phosphate) ammonium salt
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16:0 PI(5)P-d5 ammonium is the deuterium labeled 16:0 PI(5)P ammonium .
Cat. No.: HY-153532
CAS No.: 2428738-43-4
CVM-05-002 is a selective pan-phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) inhibitor, with IC50 values of 0.27 μM and 1.69 μM against PI5P4Kα and PI5P4Kβ, respectively. CVM-05-002 binds non-covalently to the ATP-binding pocket of PI5P4Kα, forming hydrophobic interactions and hydrogen bonds with pocket residues. CVM-05-002 can be used in tumor-related research .
Cat. No.: HY-149423
CAS No.: 332407-28-0
PI5P4K-β-IN-1 (compound vs1) is a potent inhibitor of PI5P4K-β (IC50: 0.80 μM) .
Cat. No.: HY-146836S2
Purity: ≥99.0%
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(Rac)-16:0 PI(5)P-d5 diammonium is deuterium labeled (Rac)-16:0 PI(5)P diammonium .
Cat. No.: HY-P701750
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PIP4K2C; PI(5)P 4-Kinase Type II Gamma; Prev. PIP5K2C; FLJ22055; Phosphatidylinositol 5-Phosphate 4-Kinase Type II Gamma; Phosphatidylinositol-5-Phosphate 4-Kinase, Type II, Gamma; Phosphatidylinositol 5-Phosphate 4-Kinase Type-2 Gamma; Phosphatidylinosit
Species:
Human
Source:
E. coli
Cat. No.: HY-P811943
Synonyms: PIP4K2B; Phosphatidylinositol-5-Phosphate 4-Kinase Type 2 Beta; PIP5KIIbeta; PIP5KIIB; PIP5K2B; Phosphatidylinositol-4-Phosphate 5-Kinase, Type II, Beta; Phosphatidylinositol 5-Phosphate 4-Kinase Type II Beta; Phosphatidylinositol 5-Phosphate 4-Kinase Type-2 Beta; 1-Phosphatidylinositol 5-Phosphate 4-Kinase 2-Beta; Diphosphoinositide Kinase 2-Beta; PI(5)P 4-Kinase Type II Beta; PIP4KII-Beta; EC 2.7.1.149; Phosphatidylinositol-5-Phosphate 4-Kinase, Type II, Beta; 1-Phosphatidylinositol-4-Phosphate Kinase; PtdIns(5)P-4-Kinase Isoform 2-Beta; PTDINS(4)P-5-Kinase; PIP5P4KB; EC 2.7.1; PI5P4KB
Cat. No.: HY-P811943A
Synonyms: PIP4K2B; Phosphatidylinositol-5-Phosphate 4-Kinase Type 2 Beta; PIP5KIIbeta; PIP5KIIB; PIP5K2B; Phosphatidylinositol-4-Phosphate 5-Kinase, Type II, Beta; Phosphatidylinositol 5-Phosphate 4-Kinase Type II Beta; Phosphatidylinositol 5-Phosphate 4-Kinase Type-2 Beta; 1-Phosphatidylinositol 5-Phosphate 4-Kinase 2-Beta; Diphosphoinositide Kinase 2-Beta; PI(5)P 4-Kinase Type II Beta; PIP4KII-Beta; EC 2.7.1.149; Phosphatidylinositol-5-Phosphate 4-Kinase, Type II, Beta; 1-Phosphatidylinositol-4-Phosphate Kinase; PtdIns(5)P-4-Kinase Isoform 2-Beta; PTDINS(4)P-5-Kinase; PIP5P4KB; EC 2.7.1; PI5P4KB
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
