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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
PIP4K2C
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "PIP4K2C" in MCE Product Catalog:
10
10 Publications Verification
Target:
Research Areas:
UNC3230 is a potent, selective and ATP-competitive PIP5K1C inhibitor with an IC50 of ~41 nM. UNC3230 also inhibits PIP4K2C and does not inhibit any of the other lipid kinases that regulate phosphoinositide levels. UNC3230 has antinociceptive and anticancer effects .
3
3 Cited Publications
MMV390048 is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kd app=0.3 µM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. falciparum and human kinases apart from human PIP4K2C, thus alleviating potential kinase-mediated safety concerns. MMV390048 is an antimalarial agent .
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WX8 (Ro 91-4714) is an ATP-competitive PIKFYVE inhibitor, with Kd values of 0.9 nM and 340 nM for PIKFYVE and PIP4K2C, respectively. WX8 (Ro 91-4714) inhibits lysosomal fission without effecting homotypic lysosomal fusion. WX8 (Ro 91-4714) is used in the research of autophagy-dependent cancer .
C24-Ceramide is an orally active competitive binding agonist of PIP4K2C (mTOR complex regulator), thereby activating the mTOR signaling pathway. At the same time, C24-Ceramide changes the membrane morphology by inducing the formation of a partially interlocked gel phase in the phospholipid bilayer. C24-Ceramide can promote the proliferation and migration of keratinocytes to accelerate skin wound healing and drive the proliferation and metastasis of gallbladder cancer cells. The level of C24-Ceramide in serum can be used as a diagnostic marker for gallbladder cancer .
Cat. No.: HY-175751
CAS No.: 3063346-83-5
LRK-4189 is an orally active CRBN-dependent PIP4K2C PROTAC degrader. LRK-4189-mediated degradation of PIP4K2C leads to intrinsic cell death and upregulation of the STAT1 pathway and signaling in microsatellite stable colorectal cancer (MSS CRC) cells. LRK-4189 can be used for the research of microsatellite-stable colorectal cancer .
Cat. No.: HY-161619
CAS No.: 2258606-34-5
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RMC-113 is a PIP4K2C and PIKfyve inhibitor with the Ki vaules of 46 nM and 370 nM. RMC-113 reverses SARS-CoV-2-induced impairment of autophagic flux. RMC-113 shows antiviral activity .
Research Areas:
TMX-4153 is a selective PIP4K2C PROTAC degrader. TMX-4153 induces PIP4K2C degradation in MOLT4 cells (DC50 = 24 nM) and HAP1 cells (DC50 = 361 nM). TMX-4153 can be used for the study of biological functions of PIP4K2C (immune modulation)-related diseases. (Pink: BTK ligand (HY-177432), Blue: VHL Ligand (HY-112078), Black: Linker) .
Research Areas:
CZC-25146 is a potent and orally active LRRK2 inhibitor with IC50 values of 4.76 nM and 6.87 nM for wild-type LRRK2 and G2019S LRRK2, respectively. CZC-25146 inhibits PLK4, GAK, TNK1, CAMKK2 and PIP4K2C as well. CZC-25146 prevents mutant LRRK2-induced injury of neurons in vitro. CZC-25146 exhibits relatively favorable pharmacokinetic properties in mice. CZC-25146 can increase normal α-1-antitrypsin (AAT) secretion and reduce inflammatory cytokines. CZC-25146 can be used to research Parkinson's disease and liver diseases .
Cat. No.: HY-177432
CAS No.: 2867519-51-3
Research Areas:
TMX-4140 is a selective PIP4K2C inhibitor with a KD of 7.2 nM for PIP4K2C over PIP4K2B. TMX-4140 can be used for synthesis of PROTAC TMX-4153 (HY-153119) .
Cat. No.: HY-RS10564
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PIP4K2C Human Pre-designed siRNA Set A contains three designed siRNAs for PIP4K2C gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-174296
TMX-4102 is a highly selective phosphatidylinositol 5-phosphate 4-kinase type II gamma (PIP4K2C) binder. TMX-4102 has binding activity to PIP4K2C (Kd = 0.45 nM) and has no significant effect on other lipid and non-lipid kinases.TMX-4102 specifically binds to PIP4K2C, regulating its scaffold function rather than its enzymatic activity. TMX-4102 can be used as a tool molecule to study the biological function and potential therapeutic value of PIP4K2C .
Synonyms: PI5P4Kα-IN-1
TM-04-176-01 (PI5P4Kα-IN-1) is a selective PIP4K2C inhibitor (Kd 3.4 nM) and PI5P4K inhibitor (IC50: 1.96 and 9.4 μM for PI5P4Kα and PI5P4Kβ, respectively). TM-04-176-01 inhibits SARS-CoV-2 replication with low cytotoxicity. TM-04-176-01 can be used for research on SARS-CoV-2 infection .
Cat. No.: HY-RS18440
Target:
Research Areas:
Pip4k2c Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pip4k2c gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS24922
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Research Areas:
Pip4k2c Rat Pre-designed siRNA Set A contains three designed siRNAs for Pip4k2c gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-15800
CAS No.: 1330003-04-7
Research Areas:
CZC-25146 hydrochloride is a potent LRRK2 inhibitor with IC50 values of 4.76 nM and 6.87 nM for wild-type LRRK2 and G2019S LRRK2, respectively. CZC-25146 hydrochloride inhibits PLK4, GAK, TNK1, CAMKK2 and PIP4K2C as well. CZC-25146 hydrochloride prevents mutant LRRK2-induced injury of neurons in vitro. CZC-25146 hydrochloride exhibits relatively favorable pharmacokinetic properties in mice. CZC-25146 hydrochloride can increase normal α-1-antitrypsin (AAT) secretion and reduce inflammatory cytokines. CZC-25146 hydrochloride can be used to research Parkinson's disease and liver diseases .
Cat. No.: HY-P701750
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PIP4K2C; PI(5)P 4-Kinase Type II Gamma; Prev. PIP5K2C; FLJ22055; Phosphatidylinositol 5-Phosphate 4-Kinase Type II Gamma; Phosphatidylinositol-5-Phosphate 4-Kinase, Type II, Gamma; Phosphatidylinositol 5-Phosphate 4-Kinase Type-2 Gamma; Phosphatidylinosit
Species:
Human
Source:
E. coli
Cat. No.: HY-110150R
CAS No.: 1031602-63-7
Target:
Research Areas:
UNC3230 (Standard) is the analytical standard of UNC3230 (HY-110150). This product is intended for research and analytical applications. UNC3230 is a potent, selective and ATP-competitive PIP5K1C inhibitor with an IC50 of ~41 nM. UNC3230 also inhibits PIP4K2C and does not inhibit any of the other lipid Kinases that regulate phosphoinositide levels. UNC3230 has antinociceptive and anticancer effects .
Cat. No.: HY-106005R
CAS No.: 1314883-11-8
Target:
Research Areas:
MMV390048 (Standard) is the analytical standard of MMV390048 (HY-106005). This product is intended for research and analytical applications. MMV390048 is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 μM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. falciparum and human kinases apart from human PIP4K2C, thus alleviating potential kinase-mediated safety concerns. MMV390048 is an antimalarial agent .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
