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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
26 Results for "
PROTAC negative Control
" in MedChemExpress (MCE) Product Catalog:
Products (26)
26 Results for "PROTAC negative Control" in MCE Product Catalog:
1
1 Cited Publications
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PROTAC STING Degrader-1 control serves as the negative control for PROTAC STING Degrader-1 (HY-150608). PROTAC STING Degrader-1 is a PROTAC degrader targeting the STING pathway .
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dTAGV-1-NEG is an inactive FKBP12 F36V PROTAC degrader, the diastereomer of dTAGV-1 (HY-145514D), and a heterobifunctional negative control molecule. dTAGV-1-NEG does not degrade any protein .
Cat. No.: HY-161157
CAS No.: 2451573-90-1
dTAG-13-NEG is a negative control of dTAG-13 (HY-114421). dTAG-13, a PROTAC-based heterobifunctional degrader, is a selective degrader of FKBP12 F36V with expression of FKBP12F36V in-frame with a protein of interest .
Cat. No.: HY-107425A
CAS No.: 1797406-72-4
Synonyms: MZP-42
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cis-MZ 1 (MZP-42) serves as a negative control for BRD4-targeted PROTAC MZ 1 (HY-107425). cis-MZ 1 cannot bind to VHL, resulting in the inability to degrade BRD4. cis-MZ 1 can be used in colorectal cancer-related research .
Cat. No.: HY-161828A
(S)-JWZ-5-13 (compound 17-Neg), a PROTAC CDK7 degrader, is a negative control compound of JWZ-5-13 (HY-161828). (S)-JWZ-5-13 displays similar in vitro CDK7 inhibition (IC50 = 21.1 nM) to JWZ-5-13, but fails to induce CDK7 degradation in cells .
Cat. No.: HY-157542
CAS No.: 2714560-39-9
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CG428-NEG is the negative control of PROTAC CG428 (HY-137465). CG428-NEG binds to TRKA, TRKB and TRKC with high affinity, with Kd values of 0.88 nM, 4.8 nM and 59.8 nM, respectively. CG428-NEG inhibits the growth of cancer cells and reduces the level of TPM3-TRKA fusion protein in cancer cells. CG428-NEG can be used in the research of colorectal cancer .
Cat. No.: HY-147099
Purity: 97.8%
dTAG-47-NEG is an inactive bifunctional negative control PROTAC and also the diastereomer of dTAGV-1 (HY-145514D). dTAG-47-NEG does not reduce the level of BCL11A-FKBP12 F36V, nor does it induce the degradation of BCL11A-FKBP12 F36V, proteins tagged with FKBP12 F36V, wild-type FKBP12, FKBP12 F36V-KRAS G12V or FKBP12 F36V-EWS/FLI. dTAG-47-NEG exerts no antiproliferative effect in cancer cells .
Cat. No.: HY-107425B
Purity: ≥99.0%
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cis-MZ 1 hydrate serves as a negative control for BRD4-targeted PROTAC MZ 1 (HY-107425). cis-MZ 1 hydrate can be used in colorectal cancer-related research .
CMP98 is a homologous PROTAC that serves as a negative control compound for CM11, a pVHL30 PROTAC degrader. CMP98 does not induce VHL protein degradation, bind to the VCB complex, or form a ternary VCB complex .
Cat. No.: HY-W586822
CAS No.: 1352827-50-9
Synonyms: Pomalidomide-methyl
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N-methylated pomalidomide (Pomalidomide-methyl), a derivative of Pomalidomide (HY-10984), is a cereblon (CRBN) ligand. N-methylated pomalidomide is unable to recruit CRBN that can be used as a negative control for Pomalidomide. N-methylated pomalidomide can be used to synthesize PROTAC .
Cat. No.: HY-145514B
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dTAGV-1-NEG TFA is an inactive FKBP12 F36V PROTAC degrader, the diastereomer of dTAGV-1 (HY-145514D), and a heterobifunctional negative control molecule. dTAGV-1-NEG TFA does not degrade any protein .
Cat. No.: HY-170859A
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AH081 is a CK1δ/ε PROTAC degrader. AH081 serves as the negative control of AH078 (HY-170859). AH081 exhibits inhibitory activity but no degradative activity against CK1δ/ε by using an inactive stereoisomer of the VHL ligand .
Cat. No.: HY-174248
PS21M is a negative control PROTAC degrader derived from CPS-021, as well as an inhibitor of ternary complex formation. PS21M attenuates the interaction with Cereblon ligase, restricting the formation of the PAK4-PROTAC-Cereblon ternary complex and the subsequent degradation of PAK4. PS21M serves as a negative control molecule to verify the degradation mechanism of CPS-021 .
Cat. No.: HY-159016
CAS No.: 3094092-93-7
SIAIS630121-NC (compound 630121-NC) is a negative control for NAMPT (nicotinamide phosphoribosyltransferase) PROTAC degrader SIAIS630121. SIAIS630121-NC shows no NAMPT degradation capability at all .
Cat. No.: HY-159015
SIAIS630120-NC is a negative control PROTAC compound synthesized using a methylated CRBN ligand, which serves as a control for SIAIS630120. SIAIS630120-NC lacks NAMPT degradation activity. SIAIS630120-NC exerts no cytotoxic effect on hematological tumor cells .
Cat. No.: HY-161157A
dTAG-13-NEG TFA is a negative control of dTAG-13 (HY-114421). dTAG-13, a PROTAC-based heterobifunctional degrader, is a selective degrader of FKBP12 F36V with expression of FKBP12F36V in-frame with a protein of interest .
Cat. No.: HY-150400A
CAS No.: 2694057-55-9
Synonyms: MS132N TFA
XF056-132 (MS132N TFA) is an inactive WDR5 PROTAC degrader with a Kd value of 106 nM against human targets, and exhibits no significant binding to the VHL complex, serves as a negative control for MS132. XF056-132 binds to WDR5, does not induce WDR5 degradation in pancreatic cancer cells, and exerts no inhibitory effect on adenocarcinoma cells. XF056-132 can be used in the research of pancreatic ductal adenocarcinoma .
Cat. No.: HY-150400
CAS No.: 2407450-73-9
Synonyms: MS132N
XF056-132 free base (MS132N) is an inactive WDR5 PROTAC degrader with a Kd value of 106 nM against human targets, and exhibits no significant binding to the VHL complex, serves as a negative control for MS132. XF056-132 free base binds to WDR5, does not induce WDR5 degradation in pancreatic cancer cells, and exerts no inhibitory effect on adenocarcinoma cells. XF056-132 free base can be used in the research of pancreatic ductal adenocarcinoma .
Cat. No.: HY-184524
CAS No.: 3035189-46-6
PROTAC HDAC4 Degrader-2 is a class IIa selective negative control for HDAC4 PROTAC degraders, with an IC50 of 0.15 μM against HDAC4 and a cellular IC50 of 0.18 μM. PROTAC HDAC4 Degrader-2 fails to effectively recruit the VHL E3 ligase, and thus does not induce significant degradation of HDAC4 protein .
Cat. No.: HY-186272
CAS No.: 3050872-64-2
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MS8847N2 is a negative control analog of an EZH2 PROTAC degrader that binds EZH2 but does not bind the VHL E3 ligase or induce EZH2 degradation .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
