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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
Piezo1
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "Piezo1" in MCE Product Catalog:
122
122 Publications Verification
Cat. No.: HY-18723
CAS No.: 448947-81-7
Target:
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Yoda 1 is a potent and selective Piezo1 agonist. Yoda 1 activates purified Piezo1 channels. Yoda 1 potently inhibits macropinocytosis induced by epidermal growth factor (EGF). Yoda 1 enhances Ca 2+ influx followed by activation of the calcium-activated potassium channel KCa3.1 and inhibition of Rac1 activation [1] .
17
17 Cited Publications
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Dooku1 is a reversibly Yoda1 antagonist with IC50 value of 1.3 μM and 1.5 μM for 2 μM Yoda1-induced Ca 2+ entry HEK 293 cells and HUVECs, respectively. Dooku1 can disrupt Yoda1-induced Piezo1 channel activity and inhibit Yoda1-induced relaxation of aorta. Dooku1 can be used for vascular physiology and disease research [1].
2
2 Cited Publications
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Jedi2 is a Piezo1 activator, but not a specific Piezo2 activator. Jedi2 binds to the mouse Piezo1 proteins with a Kd of 2770??μM [1].
1
1 Cited Publications
Cat. No.: HY-162501
CAS No.: 3041134-13-5
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Yaddle1 is an agonist of the mechano-activated ion channel (Piezo1) with a half-maximal effective concentration (MEC50) of 0.40 μM. Yaddle1 can significantly trigger Ca 2+ inflow in T cells and induce T cell activation response. Yaddle1 can be used in the study of vaccine adjuvants [1].
Cat. No.: HY-175416
CAS No.: 3081450-95-2
Synonyms: KC289
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Yoda2 (KC289), the potassium salt of Yoda1 (HY-18723), is a PIEZO1 agonist with an EC50 of 150 nM. Yoda2 evokes Ca 2+ elevation and NO-dependent relaxation. Yoda2 induces relaxation in mouse arterial and cavernous tissues. Yoda2 inhibits glucocorticoid-induced osteoclast formation and bone resorptive activity, reverses glucocorticoid-induced bone density loss and architectural deterioration, and does not induce medication-related osteonecrosis of the jaw in mice. Yoda2 can be used for the researches of hypertension and osteoporosis [1] .
Cat. No.: HY-RS10483
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PIEZO1 Human Pre-designed siRNA Set A contains three designed siRNAs for PIEZO1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS17433
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Piezo1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Piezo1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-165607S
CAS No.: 3058199-58-6
Cat. No.: HY-169332
CAS No.: 3058199-62-2
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Piezo1 agonist 1-d2 is a Piezo1 agonist and osteogenesis promoter with an EC50 of 2.21 μM. Piezo1 agonist 1-d2 activates Piezo1 and induces calcium ion influx in mesenchymal stem cells. Piezo1 agonist 1-d2 activates the Erk signaling pathway and promotes osteogenesis of mesenchymal stem cells. Piezo1 agonist 1-d2 alleviates disuse osteoporosis in a hindlimb unloading rat model. Piezo1 agonist 1-d2 can be used for research on osteoporosis [1].
Cat. No.: HY-D1765
CAS No.: 1415018-97-1
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FM 1-43FX is a fluorescent styryl membrane dye that stains lipids green. FM 1-43FX labels extracellular vesicle lipid membranes, exosomes/microvesicles, and various sensory neurons through an endocytosis/vesicle recycling-dependent mechanism, and can label NFH-, calbindin-, and TH-positive mechanoreceptor subtypes. FM 1-43FX acts as a membrane-permeable MET channel blocker, partially inhibiting PIEZO1 and PIEZO2 currents in a voltage-dependent manner, and is used to assess cochlear/zebrafish MET function and detect fungal EV lipid transfer. FM 1-43FX can be used for research on progressive hearing loss .
Cat. No.: HY-181743A
Research Areas:
Piezo1 agonist 2 hydrochloride is a blood-brain barrier-permeable Piezo1 agonist and Jedi2 (HY-131018) conjugate that utilizes LAT1. Piezo1 agonist 2 hydrochloride releases Jedi2 in mice. Piezo1 agonist 2 hydrochloride can be used for the research of neurodegenerative diseases [1].
Cat. No.: HY-181743
CAS No.: 3124796-49-9
Research Areas:
Piezo1 agonist 2 (Compound PD2) is a blood-brain barrier-permeable Piezo1 agonist and Jedi2 (HY-131018) conjugate that utilizes LAT1. Piezo1 agonist 2 releases Jedi2 in mice. Piezo1 agonist 2 can be used for the research of neurodegenerative diseases [1].
Cat. No.: HY-RS23888
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Piezo1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Piezo1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-181467
CAS No.: 3081200-39-4
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KC159 is a Yoda1 analog, as well as an agonist of Piezo1 and Piezo2. KC159 can be used for cultured adipocyte production [1].
Cat. No.: HY-18723R
CAS No.: 448947-81-7
Research Areas:
Yoda 1 (Standard) is the analytical standard of Yoda 1 (HY-18723). This product is intended for research and analytical applications. Yoda 1 is a potent and selective Piezo1 agonist. Yoda 1 activates purified Piezo1 channels. Yoda 1 potently inhibits macropinocytosis induced by epidermal growth factor (EGF). Yoda 1 enhances Ca 2+ influx followed by activation of the calcium-activated potassium channel KCa3.1 and inhibition of Rac1 activation [1] .
Cat. No.: HY-P86875
Synonyms: DHS Fam38a Family with sequence similarity 38 member A KIAA0233 Membrane protein induced by beta-amyloid treatment Mib PIEZ1_HUMAN Piezo-type mechanosensitive ion channel component 1 Piezo1 Protein FAM38A DHS Fam38a Family with sequence similarity 38 member A KIAA0233 Membrane protein induced by beta-amyloid treatment Mib PIEZ1_HUMAN Piezo-type mechanosensitive ion channel component 1 Piezo1 Protein FAM38A Protein FAM38B Protein Piezo1
Cat. No.: HY-126010R
CAS No.: 2253744-54-4
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Dooku1 (Standard) is the analytical standard of Dooku1 (HY-126010). This product is intended for research and analytical applications. Dooku1 is a reversibly Yoda1 antagonist with IC50 value of 1.3 μM and 1.5 μM for 2 μM Yoda1-induced Ca 2+ entry HEK 293 cells and HUVECs, respectively. Dooku1 can disrupt Yoda1-induced Piezo1 channel activity and inhibit Yoda1-induced relaxation of aorta. Dooku1 can be used for vascular physiology and disease research [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
