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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
27 Results for "
Pyridone
" in MedChemExpress (MCE) Product Catalog:
Products (27)
27 Results for "Pyridone" in MCE Product Catalog:
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12
12 Cited Publications
Pyridone 6 is a pan-JAK inhibitor, which potently inhibits the JAK kinase family, with IC50s of 1 nM for JAK2 and TYK2, 5 nM for JAK3, and 15 nM for JAK1, while displaying significantly weaker affinities (130 nM to >10 mM) for other protein tyrosine kinases.
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3,5,6-Trichloro-2-pyridinol (TCPy) is a chloride of 2-pyridone with oral activity. 3,5,6-Trichloro-2-pyridinol is the main degradation product of the herbicide Triclopyr and the insecticides Chlorpyrifos and chlorpyrifos-methyl. 3,5,6-Trichloro-2-pyridinol is associated with attention deficit hyperactivity disorder (ADHD) and decreased testosterone levels. 3,5,6-Trichloro-2-pyridinol causes hearing loss, hepatotoxicity and nephrotoxicity in mice .
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N-Methyl-4-pyridone-3-carboxamide (compound 4PY) is a final product of nicotinamide adenine dinucleotide (NAD) degradation .
Cat. No.: HY-160851
CAS No.: 1590403-33-0
Synonyms: AK3287; AKEX0011
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GDC-3280 (AK3287; AKEX0011) is an orally active compound based on Pirfenidone (HY-B0673)'s phenyl pyridone scaffold. GDC-3280 alleviates the inflammatory and fibrotic reaction of silicosis by inhibiting the ASK1-p38 MAPK pathway and regulating macrophage polarization. GDC-3280 exhibits anti-inflammatory and anti-fibrotic effects .
NITD-916, a 4-hydroxy-2-pyridone derivative, is an orally active mycobacterial enoyl reductase InhA inhibitor with an IC50 of 570 nM. NITD-916 forms a ternary complex with InhA and NADH to block access to the fatty acyl substrate binding pocket. NITD-916 inhibition of InhA reduces the synthesis of mycolic acids and results in cell death. NITD-916 has potent anti-tuberculosis effects .
Cat. No.: HY-65008
CAS No.: 21642-98-8
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Cat. No.: HY-14435R
CAS No.: 457081-03-7
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Pyridone 6 (Standard) is the analytical standard of Pyridone 6. This product is intended for research and analytical applications. Pyridone 6 is a pan-JAK inhibitor, which potently inhibits the JAK kinase family, with IC50s of 1 nM for JAK2 and TYK2, 5 nM for JAK3, and 15 nM for JAK1, while displaying significantly weaker affinities (130 nM to >10 mM) for other protein tyrosine kinases.
Cat. No.: HY-65036
CAS No.: 36953-37-4
Synonyms: 4-Bromo-2-Pyridone
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4-Bromo-2-hydroxypyridine (4-Bromo-2-pyridone) is a brominated pyridine/pyridone chemical building block. 4-Bromo-2-hydroxypyridine exists in tautomeric forms between 2-hydroxypyridine and pyridin-2 (1H)-one. 4-Bromo-2-hydroxypyridine is used for the synthesis of bromopyridone nucleoside analogs, phosphoramidite intermediates, and 4-phenylpyridin-2-one derivatives. 4-Bromo-2-hydroxypyridine is applied in studies on heterocyclic synthesis and oligonucleotide modification chemistry .
Cat. No.: HY-59165
CAS No.: 13466-38-1
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5-Bromopyridin-2-ol is a brominated pyridinol (2-pyridone) starting material and synthetic building block. 5-Bromopyridin-2-ol is used in the synthesis of the MNK1/2 inhibitor SEL201 (HY-112113) and the DDX3 inhibitor 7-AID .
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Cat. No.: HY-75423
CAS No.: 89488-30-2
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5-Bromo-3-methylpyridin-2-ol is a 2-pyridone-based chemical intermediate that can be used for the synthesis of the ratiometric fluorescent probe NAP-t-PY. 5-Bromo-3-methylpyridin-2-ol is applicable to research on organic synthesis and fluorescent probe development .
Cat. No.: HY-113472R
CAS No.: 769-49-3
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N-Methyl-4-pyridone-3-carboxamide (Standard) is the analytical standard of N-Methyl-4-pyridone-3-carboxamide (HY-113472). This product is intended for research and analytical applications. N-Methyl-4-pyridone-3-carboxamide (compound 4PY) is a final product of nicotinamide adenine dinucleotide (NAD) degradation .
Cat. No.: HY-132834S
CAS No.: 1020719-24-7
Cat. No.: HY-21720S
CAS No.: 2733718-04-0
Cat. No.: HY-125161
CAS No.: 108353-14-6
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MT0703 is an aminothiazolyl glycyl cephalosporin with a 1,5-dihydroxy-4-pyridone-2-carbonyl group and has good anti-Pseudomonas activity.
Cat. No.: HY-19951A
CAS No.: 162763-53-3
A-867191 hydrochloride is a 2-pyridone DNA gyrase inhibitor. A-867191 hydrochloride has antibacterial activity. A-867191 hydrochloride can be used for research on infections .
Cat. No.: HY-N10209
CAS No.: 1538575-22-2
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Cat. No.: HY-Y0191S
Synonyms: 2-Pyridone-d5
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
