Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
135 Results for "
RAW264.7 cell
" in MedChemExpress (MCE) Product Catalog:
Products (135)
135 Results for "RAW264.7 cell" in MCE Product Catalog:
8
8 Publications Verification
ML115, a molecular probe of the signal transducer, is a selective STAT3 agonist, with an EC50 of 2 nM. ML115 increases the expression of BCL3, a known STAT3-dependent oncogene. ML115 is inactive against the related STAT1, STAT5 and NF-κB anti-targets. ML115 counteracts the effects of Ginsenoside Rc (HY-N0042) on cell viability and inflammatory responses in LPS (HY-D1056)-stimulated H9c2 and RAW264.7 cells, while altering oxidative stress markers. ML115 can be used for the study of breast and prostate cancers .
4
4 Cited Publications
Cat. No.: HY-N0617
CAS No.: 80651-76-9
Category:
Cardiovascular Disease Moraceae Extract Morus alba Linn. Extract Flavanonols Plant Flavonoids Phenols Polyphenols Disease Research Fields Inflammation/Immunology
Target:
3
3 Cited Publications
Cat. No.: HY-N0569
CAS No.: 18449-41-7
2
Category:
Plant Coumarins Cimicifuga racemosa (L.) Nutt. Extract Phenylpropanoids Disease Research Fields Inflammation/Immunology Ranunculaceae Extract
Target:
2
2
2 Cited Publications
Cat. No.: HY-N0515
CAS No.: 945619-74-9
2
1
1 Cited Publications
Synonyms: 4-Hydroxy-3-methoxycinnamaldehyde
Category:
Plant Monophenols Simple Phenylpropanols Phenols Phenylpropanoids Other Families Extract Disease Research Fields Inflammation/Immunology
Target:
1
1 Cited Publications
Cat. No.: HY-N0569R
CAS No.: 18449-41-7
1
Category:
Plant Cyperaceae Extract Terpenoids Sesquiterpenes Cyperus rotundus L. Extract Disease Research Fields Inflammation/Immunology
Target:
1
1 Cited Publications
Target:
Research Areas:
T-5342126 is a toll-like receptor 4 (TLR4) antagonist. It reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50=27.8 μM), as well as decreases LPS-induced IL-8, TNF-α, and IL-6 production in isolated human whole blood (IC50s=110.5, 315.6, and 318.4 μM, respectively). T-5342126 (82 mg/kg) reduces ethanol intake and the abundance of ionized calcium-binding adapter molecule 1 (Iba1), a marker of microglial activation, in the central nucleus of the amygdala in ethanol-dependent mice.
1
1 Cited Publications
Cat. No.: HY-N7012
CAS No.: 29080-58-8
Synonyms: 5-Hydroxy-3',4',7-trimethoxyflavone
Cat. No.: HY-155751
Purity: 99.37%
Research Areas:
HMGB1-IN-1 (compound 6) displays strong NO inhibitory effect in RAW264.7 cells with IC50 value of 15.9 ± 0.6 μM. HMGB1-IN-1 inhibit the HMGB1/NF-κB/NLRP3 pathway. HMGB1-IN-1 shows good anti-inflammatory activity and good anti-sepsis effects in kidney injury .
Category:
Quinones Plant Monophenols Anthraquinones Phenols Damnacanthus major Sieb. et Zucc. Extract Rubiaceae Extract
Target:
Cat. No.: HY-W068682
CAS No.: 528-71-2
Synonyms: Hemipyocyanine; 1-Phenazinol; Hemi-pyocyanin
Research Areas:
Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
1-Hydroxyphenazine (Hemipyocyanine; 1-Phenazinol; Hemi-pyocyanin) is an inhibitor for α-Amylase with an IC50 of 3.1 μg/mL . 1-Hydroxyphenazine exhibits anticancer and anti-inflammatory activity against cells A549, 1321N1 and RAW264.7, antifungal and antibacterial activity against strains Candida albicans, Aspergillus fumigatus, Escherichia coli and Xanthomonas campestris .
Research Areas:
3‑Penten‑2‑one (Ethylideneacetone; (3Z)-pent-3-en-2-one) is an endogenous metabolite and a small-molecule ketone with antifungal activity. 3‑Penten‑2‑one induces HO‑1 expression, inhibits iNOS expression and NO production in lipopolysaccharide-activated RAW264.7 macrophages, and exerts anti-inflammatory effects. 3‑Penten‑2‑one inhibits the growth of Penicillium italicum, disrupts fungal hyphal and spore morphology and damages the cell membrane, and also exhibits inhibitory activity against various plant pathogenic fungi. 3-Penten-2-one can be used in research related to fungal infections and inflammatory diseases .
Cat. No.: HY-171274
CAS No.: 149775-26-8
Target:
Research Areas:
DOCK5-IN-1 (Compound 14) is the inhibitor for DOCK5 and exhibits no toxicity (100 μM) in cell RAW264.7 .
Target:
Research Areas:
Ethyl gentisate (Ethyl 2,5-dihydroxybenzoate) is a dual modulator for cell differentiation, that enhances the osteogenic differentiation of human mesenchymal stem cells (hMSCs) and alkaline phosphatase activity, inhibits RANKL-activated osteoclastogenesis in RAW264.7 cells, and balances the bone remodeling process .
Cat. No.: HY-W753791
CAS No.: 2111-75-3
Target:
Research Areas:
(±)-Perillaldehyde has an antidepressant effect by modulating the olfactory nervous system in a mouse model of stress-induced depression. (±)-Perillaldehyde also has anti-inflammatory activity, inducing JNK activation in RAW264.7 cells and inhibiting the expression of TNF-α, with an IC50 of 171.7 μM .
Cat. No.: HY-N9337
CAS No.: 21233-18-1
Category:
Metabolic Disease Gentianaceae Extract Plant Iridoids Terpenoids Phenols Polyphenols Swertia mussotii Franch. Extract Disease Research Fields Inflammation/Immunology
Target:
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
