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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
STK4
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "STK4" in MCE Product Catalog:
2
2 Cited Publications
Target:
Research Areas:
SBP-3264 is a YAP activator and STK/MST inhibitor with IC50 values of 36 nM against STK3/MST2 and 24 nM against STK4/MST1. SBP-3264 modulates the Hippo signaling pathway. SBP-3264 can be used for the research of acute myeloid leukemia .
2
2 Cited Publications
Cat. No.: HY-P74742
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: STK4; Kinase Responsive To Stress 2; Serine/Threonine Kinase 4; Mammalian Sterile 20-Like 1; MST1; STE20-Like Kinase MST1; KRS2; Non-Specific Serine/Threonine Protein Kinase; YSK3; Hippo (Drosophila) Homolog; Mammalian STE20-Like Protein Kinase 1; Yeast S
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-RS13941
Target:
Research Areas:
STK4 Human Pre-designed siRNA Set A contains three designed siRNAs for STK4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS18154
Target:
Research Areas:
Stk4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Stk4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS24628
Target:
Research Areas:
Stk4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Stk4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-131731
CAS No.: 2353563-15-0
PROTAC STK4 Degrader-1 is a cereblon-recruiting STK4 PROTAC degrader. PROTAC STK4 Degrader-1 mediates ubiquitination and proteasomal degradation of STK4, induces dose- and time-dependent downregulation of STK4 in cancer cells, and exhibits reduced cytotoxicity in cereblon-knockout cells. PROTAC STK4 Degrader-1 can be used in research related to multiple myeloma .
Cat. No.: HY-188093
CAS No.: 2353563-37-6
Research Areas:
STK4 binder-1 is a target protein ligand that can be used for the synthesis of PROTACs, such as PROTAC STK4 Degrader-1 (HY-131731).
Cat. No.: HY-189809
Target:
Research Areas:
STK3-IN-1 is an ATP-binding site inhibitor of STK3. STK3-IN-1 blocks the enzymatic activity of STK3 with an IC50 of 3.52 nM. STK3-IN-1 also exhibits inhibitory activity against STK4, a homolog closely related to STK3, with an IC50 of 14.73 nM .
Cat. No.: HY-RS09991
Target:
Research Areas:
Pak3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pak3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P702744
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: STK4; Kinase Responsive To Stress 2; Serine/Threonine Kinase 4; Mammalian Sterile 20-Like 1; MST1; STE20-Like Kinase MST1; KRS2; Non-Specific Serine/Threonine Protein Kinase; YSK3; Hippo (Drosophila) Homolog; Mammalian STE20-Like Protein Kinase 1; Yeast S
Species:
Human
Source:
E. coli
Cat. No.: HY-189693
CAS No.: 459193-26-1
Target:
Research Areas:
c-Met/STAT3-IN-2 is a c-Met and STAT3 inhibitor with IC50 values of 0.20 μM and 0.74 μM, respectively. c-Met/STAT3-IN-2 inhibits c-Met and STAT3 phosphorylation, binds to the STAT3 SH2 domain, and blocks pTyr705 recognition. c-Met/STAT3-IN-2 induces cancer cell apoptosis (apoptosis) and G2/M phase arrest, upregulates P53, Bax, PUMA, caspases-3, -8, and -9, and downregulates Bcl-2. c-Met/STAT3-IN-2 has broad-spectrum anticancer activity, inhibits cancer cell proliferation, and exhibits lethal activity against various cancer cell lines. c-Met/STAT3-IN-2 shows minimal off-target inhibition of STK3, STK4, PI3Kdelta, and VEGFR3. c-Met/STAT3-IN-2 can be used for research related to colorectal cancer, leukemia, non-small cell lung cancer, and breast cancer cells .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
